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Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia.
Front Immunol. 2018; 9:2640.FI

Abstract

Influenza and other respiratory viral infections are the most common type of acute respiratory infection. Viral infections predispose patients to secondary bacterial infections, which often have a more severe clinical course. The mechanisms underlying post-viral bacterial infections are complex, and include multifactorial processes mediated by interactions between viruses, bacteria, and the host immune system. Studies over the past 15 years have demonstrated that unique microbial communities reside on the mucosal surfaces of the gastrointestinal tract and the respiratory tract, which have both direct and indirect effects on host defense against viral infections. In addition, antiviral immune responses induced by acute respiratory infections such as influenza are associated with changes in microbial composition and function ("dysbiosis") in the respiratory and gastrointestinal tract, which in turn may alter subsequent immune function against secondary bacterial infection or alter the dynamics of inter-microbial interactions, thereby enhancing the proliferation of potentially pathogenic bacterial species. In this review, we summarize the literature on the interactions between host microbial communities and host defense, and how influenza, and other acute respiratory viral infections disrupt these interactions, thereby contributing to the pathogenesis of secondary bacterial infections.

Authors+Show Affiliations

Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, United States. Toranomon Hospital, Tokyo, Japan.Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, United States. Veterans Affairs Healthcare System, Ann Arbor, MI, United States.Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, United States. Veterans Affairs Healthcare System, Ann Arbor, MI, United States.Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, United States. Veterans Affairs Healthcare System, Ann Arbor, MI, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

30505304

Citation

Hanada, Shigeo, et al. "Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia." Frontiers in Immunology, vol. 9, 2018, p. 2640.
Hanada S, Pirzadeh M, Carver KY, et al. Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. Front Immunol. 2018;9:2640.
Hanada, S., Pirzadeh, M., Carver, K. Y., & Deng, J. C. (2018). Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. Frontiers in Immunology, 9, 2640. https://doi.org/10.3389/fimmu.2018.02640
Hanada S, et al. Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. Front Immunol. 2018;9:2640. PubMed PMID: 30505304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. AU - Hanada,Shigeo, AU - Pirzadeh,Mina, AU - Carver,Kyle Y, AU - Deng,Jane C, Y1 - 2018/11/16/ PY - 2018/08/04/received PY - 2018/10/26/accepted PY - 2018/12/4/entrez PY - 2018/12/7/pubmed PY - 2019/10/23/medline KW - bacterial pneumonia KW - gut microbiome KW - host-microbe interaction KW - influenza KW - respiratory viral infection KW - viral-bacterial interaction SP - 2640 EP - 2640 JF - Frontiers in immunology JO - Front Immunol VL - 9 N2 - Influenza and other respiratory viral infections are the most common type of acute respiratory infection. Viral infections predispose patients to secondary bacterial infections, which often have a more severe clinical course. The mechanisms underlying post-viral bacterial infections are complex, and include multifactorial processes mediated by interactions between viruses, bacteria, and the host immune system. Studies over the past 15 years have demonstrated that unique microbial communities reside on the mucosal surfaces of the gastrointestinal tract and the respiratory tract, which have both direct and indirect effects on host defense against viral infections. In addition, antiviral immune responses induced by acute respiratory infections such as influenza are associated with changes in microbial composition and function ("dysbiosis") in the respiratory and gastrointestinal tract, which in turn may alter subsequent immune function against secondary bacterial infection or alter the dynamics of inter-microbial interactions, thereby enhancing the proliferation of potentially pathogenic bacterial species. In this review, we summarize the literature on the interactions between host microbial communities and host defense, and how influenza, and other acute respiratory viral infections disrupt these interactions, thereby contributing to the pathogenesis of secondary bacterial infections. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/30505304/Respiratory_Viral_Infection_Induced_Microbiome_Alterations_and_Secondary_Bacterial_Pneumonia_ L2 - https://doi.org/10.3389/fimmu.2018.02640 DB - PRIME DP - Unbound Medicine ER -