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Enhancement of lipid content and inflammatory cytokine secretion in SZ95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation.
Exp Dermatol. 2019 02; 28(2):207-210.ED

Abstract

A relationship between acne and free fatty acids (FFAs) has been suggested recently. However, the effects of FFAs on sebaceous glands are still largely unknown. At the same time, the role of FFAs during chronic inflammation is well established. Considering that FFAs are also a major component of sebum, it is likely that changes in FFA affect both the synthesis of sebum and the inflammatory response in sebaceous glands. In this study, we examined a hypothesis that FFAs increase the production of sebum and induce inflammation in the sebaceous glands. We found that treatment of SZ95 sebocytes with exogenously applied palmitic acid (PA), a major saturated FFA, induced a significant increase in intracellular lipid levels. Moreover, PA treatment also increased the expression and secretion of the proinflammatory cytokines in SZ95 sebocytes. We also found that Toll-like receptors were required for the inflammatory response triggered by PA. The results of our study strengthen the notion about the link between acne and FFAs and suggest the mechanism underlying this relationship. Our results serve as a foundation for future work that will explore the association between FFA and acne and pave way to the development of novel treatment options for acne.

Authors+Show Affiliations

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea.Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany.Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea.Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30506807

Citation

Choi, Chong Won, et al. "Enhancement of Lipid Content and Inflammatory Cytokine Secretion in SZ95 Sebocytes By Palmitic Acid Suggests a Potential Link Between Free Fatty Acids and Acne Aggravation." Experimental Dermatology, vol. 28, no. 2, 2019, pp. 207-210.
Choi CW, Kim Y, Kim JE, et al. Enhancement of lipid content and inflammatory cytokine secretion in SZ95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation. Exp Dermatol. 2019;28(2):207-210.
Choi, C. W., Kim, Y., Kim, J. E., Seo, E. Y., Zouboulis, C. C., Kang, J. S., Youn, S. W., & Chung, J. H. (2019). Enhancement of lipid content and inflammatory cytokine secretion in SZ95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation. Experimental Dermatology, 28(2), 207-210. https://doi.org/10.1111/exd.13855
Choi CW, et al. Enhancement of Lipid Content and Inflammatory Cytokine Secretion in SZ95 Sebocytes By Palmitic Acid Suggests a Potential Link Between Free Fatty Acids and Acne Aggravation. Exp Dermatol. 2019;28(2):207-210. PubMed PMID: 30506807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancement of lipid content and inflammatory cytokine secretion in SZ95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation. AU - Choi,Chong Won, AU - Kim,Yejin, AU - Kim,Ji Eun, AU - Seo,Eun Young, AU - Zouboulis,Christos C, AU - Kang,Jae Seung, AU - Youn,Sang Woong, AU - Chung,Jin Ho, PY - 2018/06/19/received PY - 2018/10/27/revised PY - 2018/11/17/accepted PY - 2018/12/7/pubmed PY - 2020/6/18/medline PY - 2018/12/4/entrez SP - 207 EP - 210 JF - Experimental dermatology JO - Exp. Dermatol. VL - 28 IS - 2 N2 - A relationship between acne and free fatty acids (FFAs) has been suggested recently. However, the effects of FFAs on sebaceous glands are still largely unknown. At the same time, the role of FFAs during chronic inflammation is well established. Considering that FFAs are also a major component of sebum, it is likely that changes in FFA affect both the synthesis of sebum and the inflammatory response in sebaceous glands. In this study, we examined a hypothesis that FFAs increase the production of sebum and induce inflammation in the sebaceous glands. We found that treatment of SZ95 sebocytes with exogenously applied palmitic acid (PA), a major saturated FFA, induced a significant increase in intracellular lipid levels. Moreover, PA treatment also increased the expression and secretion of the proinflammatory cytokines in SZ95 sebocytes. We also found that Toll-like receptors were required for the inflammatory response triggered by PA. The results of our study strengthen the notion about the link between acne and FFAs and suggest the mechanism underlying this relationship. Our results serve as a foundation for future work that will explore the association between FFA and acne and pave way to the development of novel treatment options for acne. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/30506807/Enhancement_of_lipid_content_and_inflammatory_cytokine_secretion_in_SZ95_sebocytes_by_palmitic_acid_suggests_a_potential_link_between_free_fatty_acids_and_acne_aggravation_ L2 - https://doi.org/10.1111/exd.13855 DB - PRIME DP - Unbound Medicine ER -