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Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review.
Crit Rev Food Sci Nutr. 2019; 59(6):965-981.CR

Abstract

BACKGROUND

Multiple micronutrient supplementation has been suggested to have a role on health outcomes in patients with heart failure (HF), but the evidence is inconclusive.

OBJECTIVE

To elucidate the role of multiple micronutrient supplementation in heart failure we performed a comprehensive review of the literature.

METHODS AND RESULTS

The search in databases included PUBMED (until June 2018) to detect randomized controlled trials (RCTs) and meta-analyzes that investigated the impact of micronutrient supplementation in HF.

RESULTS

With more than 2357 titles and abstracts reviewed, we included only the studies suitable for the final review. Whether alone or in combination, micronutrients have been found to improve the health outcomes of patients with HF by improving symptoms, work capacity and left ventricular ejection fraction (LVEF), thus increasing the quality of life in these patients.

CONCLUSION

Future studies are needed to document the effects of multiple micronutrient associations in order to include them in nutritional guidelines to increase survival and to improve quality of life in patients with heart failure.

Authors+Show Affiliations

a Department of Cardiology, Discipline of Preventive Cardiology , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.a Department of Cardiology, Discipline of Preventive Cardiology , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.b Department of Internal Medicine, Discipline of Medical Semiology II , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.a Department of Cardiology, Discipline of Preventive Cardiology , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.a Department of Cardiology, Discipline of Preventive Cardiology , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.a Department of Cardiology, Discipline of Preventive Cardiology , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.c Institute of Chinese Medical Sciences , University of Macau , Taipa , China.d Department of Cardiology, Discipline of Cardiology II , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30507249

Citation

Dragan, Simona, et al. "Benefits of Multiple Micronutrient Supplementation in Heart Failure: a Comprehensive Review." Critical Reviews in Food Science and Nutrition, vol. 59, no. 6, 2019, pp. 965-981.
Dragan S, Buleu F, Christodorescu R, et al. Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review. Crit Rev Food Sci Nutr. 2019;59(6):965-981.
Dragan, S., Buleu, F., Christodorescu, R., Cobzariu, F., Iurciuc, S., Velimirovici, D., Xiao, J., & Luca, C. T. (2019). Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review. Critical Reviews in Food Science and Nutrition, 59(6), 965-981. https://doi.org/10.1080/10408398.2018.1540398
Dragan S, et al. Benefits of Multiple Micronutrient Supplementation in Heart Failure: a Comprehensive Review. Crit Rev Food Sci Nutr. 2019;59(6):965-981. PubMed PMID: 30507249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review. AU - Dragan,Simona, AU - Buleu,Florina, AU - Christodorescu,Ruxandra, AU - Cobzariu,Florin, AU - Iurciuc,Stela, AU - Velimirovici,Dana, AU - Xiao,Jianbo, AU - Luca,Constantin Tudor, Y1 - 2018/12/03/ PY - 2018/12/7/pubmed PY - 2019/10/30/medline PY - 2018/12/4/entrez KW - Heart failure KW - coenzyme Q10 KW - comprehensive review KW - energetic metabolism KW - micronutrient supplementation KW - vitamin D SP - 965 EP - 981 JF - Critical reviews in food science and nutrition JO - Crit Rev Food Sci Nutr VL - 59 IS - 6 N2 - BACKGROUND: Multiple micronutrient supplementation has been suggested to have a role on health outcomes in patients with heart failure (HF), but the evidence is inconclusive. OBJECTIVE: To elucidate the role of multiple micronutrient supplementation in heart failure we performed a comprehensive review of the literature. METHODS AND RESULTS: The search in databases included PUBMED (until June 2018) to detect randomized controlled trials (RCTs) and meta-analyzes that investigated the impact of micronutrient supplementation in HF. RESULTS: With more than 2357 titles and abstracts reviewed, we included only the studies suitable for the final review. Whether alone or in combination, micronutrients have been found to improve the health outcomes of patients with HF by improving symptoms, work capacity and left ventricular ejection fraction (LVEF), thus increasing the quality of life in these patients. CONCLUSION: Future studies are needed to document the effects of multiple micronutrient associations in order to include them in nutritional guidelines to increase survival and to improve quality of life in patients with heart failure. SN - 1549-7852 UR - https://www.unboundmedicine.com/medline/citation/30507249/Benefits_of_multiple_micronutrient_supplementation_in_heart_failure:_A_comprehensive_review_ L2 - http://www.tandfonline.com/doi/full/10.1080/10408398.2018.1540398 DB - PRIME DP - Unbound Medicine ER -