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Asthma control in preschool children with small airway function as measured by IOS and fractional exhaled nitric oxide.
Respir Med. 2018 12; 145:8-13.RM

Abstract

OBJECTIVE

This study investigated the accuracy of impulse oscillometry (IOS) combined with fractional exhaled nitric oxide (FeNO) to assess asthma control among preschool children.

METHODS

A total of 79 preschool children(3-6 year old) with asthma and 25 healthy preschool children who visited a paediatrician were enrolled in this study. All of the children were tested for allergens, respiratory system resistance (at 5 and 20 Hz [R5, R20]), respiratory system reactance (at 5 Hz [X5]), the resonant frequency of reactance (Fres), and the area under the reactance curve (between 5 Hz and Fres (reactance area [AX]) using IOS and FeNO. A paediatric respiratory specialist who was unaware of the IOS and FeNO results assigned children with asthma to either the asthma-controlled group (n = 27) or the asthma-uncontrolled group (n = 52) based on the Global Initiative for Asthma (GINA) criteria. A healthy control group (n = 25) was also included. The relationships between the FeNO and IOS values as well as the asthma control of the three groups were analysed, and the areas under the curve (AUCs) were calculated for each measure.

RESULTS

(1) During the controlled group, means±standard deviations of AX, R5-20, R5, X5 and FeNO were 26.15 ± 7.534, 3.52 ± 1.311,9.97 ± 1.576,-3.85 ± 0.572,-3.85 ± 0.572. During the uncontrolled group, means±standard deviations of AX,R5-20,R5,X5 and FeNO were 38.34 ± 13.563,5.36 ± 1.545,11.41 ± 2.029,-5.07 ± 1.554,36.40 ± 21.07. Among preschool children, significant differences were observed between the controlled and uncontrolled group with regard to the small airway functional parameters (AX, R5-20, R5, and X5) and FeNO(P <0.05).(2) A receiver operating characteristic (ROC) analysis showed that the AUCs were 0.786 for FeNO alone, 0.751 for X5 alone, and 0.866 for X5 combined with FeNO (cut-off value: 27 ppb).

CONCLUSION

FeNO combined with the small airway function parameter X5 accurately assessed asthma control among preschool children.

Authors+Show Affiliations

Department of Pediatrics, First Affiliated Hospital to Army Medical University, NO.30, Gao Tanyan Street, Shapingba District, Chongqing, China. Electronic address: zengjing8903@163.com.Department of Pediatrics, First Affiliated Hospital to Army Medical University, NO.30, Gao Tanyan Street, Shapingba District, Chongqing, China. Electronic address: chenzhiqiang_cc@163.com.Department of Pediatrics, First Affiliated Hospital to Army Medical University, NO.30, Gao Tanyan Street, Shapingba District, Chongqing, China. Electronic address: huyingxixi@sina.com.Department of Pediatrics, First Affiliated Hospital to Army Medical University, NO.30, Gao Tanyan Street, Shapingba District, Chongqing, China. Electronic address: 861097015@qq.com.Department of Pediatrics, First Affiliated Hospital to Army Medical University, NO.30, Gao Tanyan Street, Shapingba District, Chongqing, China. Electronic address: 26898649@qq.com.Department of Pediatrics, First Affiliated Hospital to Army Medical University, NO.30, Gao Tanyan Street, Shapingba District, Chongqing, China. Electronic address: liaowei01@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30509720

Citation

Zeng, Jing, et al. "Asthma Control in Preschool Children With Small Airway Function as Measured By IOS and Fractional Exhaled Nitric Oxide." Respiratory Medicine, vol. 145, 2018, pp. 8-13.
Zeng J, Chen Z, Hu Y, et al. Asthma control in preschool children with small airway function as measured by IOS and fractional exhaled nitric oxide. Respir Med. 2018;145:8-13.
Zeng, J., Chen, Z., Hu, Y., Hu, Q., Zhong, S., & Liao, W. (2018). Asthma control in preschool children with small airway function as measured by IOS and fractional exhaled nitric oxide. Respiratory Medicine, 145, 8-13. https://doi.org/10.1016/j.rmed.2018.10.009
Zeng J, et al. Asthma Control in Preschool Children With Small Airway Function as Measured By IOS and Fractional Exhaled Nitric Oxide. Respir Med. 2018;145:8-13. PubMed PMID: 30509720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asthma control in preschool children with small airway function as measured by IOS and fractional exhaled nitric oxide. AU - Zeng,Jing, AU - Chen,Zhiqiang, AU - Hu,Ying, AU - Hu,Qi, AU - Zhong,Shimin, AU - Liao,Wei, Y1 - 2018/10/16/ PY - 2018/06/19/received PY - 2018/09/04/revised PY - 2018/10/10/accepted PY - 2018/12/5/entrez PY - 2018/12/5/pubmed PY - 2019/10/9/medline KW - Asthma KW - Asthma control KW - Children KW - Exhaled nitric oxide KW - Small airway function SP - 8 EP - 13 JF - Respiratory medicine JO - Respir Med VL - 145 N2 - OBJECTIVE: This study investigated the accuracy of impulse oscillometry (IOS) combined with fractional exhaled nitric oxide (FeNO) to assess asthma control among preschool children. METHODS: A total of 79 preschool children(3-6 year old) with asthma and 25 healthy preschool children who visited a paediatrician were enrolled in this study. All of the children were tested for allergens, respiratory system resistance (at 5 and 20 Hz [R5, R20]), respiratory system reactance (at 5 Hz [X5]), the resonant frequency of reactance (Fres), and the area under the reactance curve (between 5 Hz and Fres (reactance area [AX]) using IOS and FeNO. A paediatric respiratory specialist who was unaware of the IOS and FeNO results assigned children with asthma to either the asthma-controlled group (n = 27) or the asthma-uncontrolled group (n = 52) based on the Global Initiative for Asthma (GINA) criteria. A healthy control group (n = 25) was also included. The relationships between the FeNO and IOS values as well as the asthma control of the three groups were analysed, and the areas under the curve (AUCs) were calculated for each measure. RESULTS: (1) During the controlled group, means±standard deviations of AX, R5-20, R5, X5 and FeNO were 26.15 ± 7.534, 3.52 ± 1.311,9.97 ± 1.576,-3.85 ± 0.572,-3.85 ± 0.572. During the uncontrolled group, means±standard deviations of AX,R5-20,R5,X5 and FeNO were 38.34 ± 13.563,5.36 ± 1.545,11.41 ± 2.029,-5.07 ± 1.554,36.40 ± 21.07. Among preschool children, significant differences were observed between the controlled and uncontrolled group with regard to the small airway functional parameters (AX, R5-20, R5, and X5) and FeNO(P <0.05).(2) A receiver operating characteristic (ROC) analysis showed that the AUCs were 0.786 for FeNO alone, 0.751 for X5 alone, and 0.866 for X5 combined with FeNO (cut-off value: 27 ppb). CONCLUSION: FeNO combined with the small airway function parameter X5 accurately assessed asthma control among preschool children. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/30509720/Asthma_control_in_preschool_children_with_small_airway_function_as_measured_by_IOS_and_fractional_exhaled_nitric_oxide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(18)30315-9 DB - PRIME DP - Unbound Medicine ER -