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Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature.
World J Clin Cases 2018; 6(14):862-868WJ

Abstract

Vasoactive intestinal peptide-producing tumors (VIPoma) usually originate in the pancreas and are characterized by diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). In adults, nonpancreatic VIPoma is very rare. Herein, we report an unusual case of VIP-producing pheochromocytoma marked by persistent shock, flushing, and watery diarrhea and high sensitivity to octreotide. A 53-year-old woman was hospitalized for sudden-onset hypertension with convulsions, which then rapidly evolved to persistent shock, flushing, and watery diarrhea. Abdominal computed tomography indicated a left adrenal mass, accompanied by bleeding; and marked elevations of both plasma catecholamine and VIP concentrations were documented via laboratory testing. Surprisingly, all clinical symptoms responded swiftly to octreotide treatment. Once surgically treated, hormonal levels normalized in this patient, and the clinical symptoms dissipated. Postoperative pathological and immunohistopathological studies confirmed a VIP-secreting pheochromocytoma with strong, diffuse positivity for somatostatin receptor type 2. During a 6-mo follow-up period, she seemed in good health and was symptom-free.

Authors+Show Affiliations

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. zhaom@sj-hospital.org.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

30510956

Citation

Hu, Xiao, et al. "Octreotide Reverses Shock Due to Vasoactive Intestinal Peptide-secreting Adrenal Pheochromocytoma: a Case Report and Review of Literature." World Journal of Clinical Cases, vol. 6, no. 14, 2018, pp. 862-868.
Hu X, Cao W, Zhao M. Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature. World J Clin Cases. 2018;6(14):862-868.
Hu, X., Cao, W., & Zhao, M. (2018). Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature. World Journal of Clinical Cases, 6(14), pp. 862-868. doi:10.12998/wjcc.v6.i14.862.
Hu X, Cao W, Zhao M. Octreotide Reverses Shock Due to Vasoactive Intestinal Peptide-secreting Adrenal Pheochromocytoma: a Case Report and Review of Literature. World J Clin Cases. 2018 Nov 26;6(14):862-868. PubMed PMID: 30510956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature. AU - Hu,Xiao, AU - Cao,Wei, AU - Zhao,Min, PY - 2018/09/05/received PY - 2018/10/15/revised PY - 2018/10/17/accepted PY - 2018/12/5/entrez PY - 2018/12/5/pubmed PY - 2018/12/5/medline KW - Case report KW - Diarrhea KW - Flushing KW - Octreotide KW - Pheochromocytoma KW - Shock KW - Vasoactive intestinal peptide SP - 862 EP - 868 JF - World journal of clinical cases JO - World J Clin Cases VL - 6 IS - 14 N2 - Vasoactive intestinal peptide-producing tumors (VIPoma) usually originate in the pancreas and are characterized by diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). In adults, nonpancreatic VIPoma is very rare. Herein, we report an unusual case of VIP-producing pheochromocytoma marked by persistent shock, flushing, and watery diarrhea and high sensitivity to octreotide. A 53-year-old woman was hospitalized for sudden-onset hypertension with convulsions, which then rapidly evolved to persistent shock, flushing, and watery diarrhea. Abdominal computed tomography indicated a left adrenal mass, accompanied by bleeding; and marked elevations of both plasma catecholamine and VIP concentrations were documented via laboratory testing. Surprisingly, all clinical symptoms responded swiftly to octreotide treatment. Once surgically treated, hormonal levels normalized in this patient, and the clinical symptoms dissipated. Postoperative pathological and immunohistopathological studies confirmed a VIP-secreting pheochromocytoma with strong, diffuse positivity for somatostatin receptor type 2. During a 6-mo follow-up period, she seemed in good health and was symptom-free. SN - 2307-8960 UR - https://www.unboundmedicine.com/medline/citation/30510956/Octreotide_reverses_shock_due_to_vasoactive_intestinal_peptide-secreting_adrenal_pheochromocytoma:_A_case_report_and_review_of_literature L2 - http://www.wjgnet.com/2307-8960/full/v6/i14/862.htm DB - PRIME DP - Unbound Medicine ER -
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