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Impact of Nutritional Status on Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) Aggressiveness.
Nutrients 2018; 10(12)N

Abstract

Neuroendocrine tumors (NETs) are rare neoplasms mostly originating from the gastroenteropancreatic tract (GEP-NETs). Data regarding nutritional status in GEP-NET patients are limited. The aim of the study was to investigate the nutritional status and adherence to the Mediterranean Diet (MD) in GEP-NET patients and to correlate them with tumor aggressiveness. A cross-sectional case-control observational study was conducted enrolling 83 patients with well-differentiated G1/G2 GEP-NETs after resection, as well as 83 healthy subjects, age, sex and body mass index-matched. Nutritional status was assessed by evaluating with Bioelectrical Impedance analysis and its phase angle (PhA), adherence to the MD according to PREDIMED score, dietary assessment, anthropometric parameters, and clinico-pathological characteristics. GEP-NET patients consumed less frequently vegetables, fruits, wine, fish/seafood, nuts, and more frequently red/processed meats, butter, cream, margarine, and soda drinks than controls. Patients with more aggressive disease presented a lower adherence to MD according to PREDIMED categories in comparison to G1, localized and free/stable disease status. A smaller PhA value and a lower PREDIMED score were significantly correlated with G2 tumor, metastases, and progressive disease. To the best of our knowledge, this is the first study reporting an association between nutritional status and tumor aggressiveness in a selected group of GEP-NETs. Moreover, higher intakes of food of MD, may represent a potential tool for prevention of tumor aggressiveness. Thus, a skilled nutritionist should be an integral part of the multidisciplinary management of GEP-NET patients.

Authors+Show Affiliations

Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy. luigi.barrea@unina.it.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy. altieri.barbara@gmail.com. Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany. altieri.barbara@gmail.com.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy. giovanna.muscogiuri@gmail.com.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy. daniela.laudisio@libero.it.Department of Pharmacy, University of Naples "Federico II", Italy; Via Domenico Montesano, 49, 80131 Naples, Italy. giuseppe.annunziata@unina.it.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy. colao@unina.it.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy. afaggian@unina.it.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini, 5, 80131 Naples, Italy. sisavast@unina.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30513732

Citation

Barrea, Luigi, et al. "Impact of Nutritional Status On Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) Aggressiveness." Nutrients, vol. 10, no. 12, 2018.
Barrea L, Altieri B, Muscogiuri G, et al. Impact of Nutritional Status on Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) Aggressiveness. Nutrients. 2018;10(12).
Barrea, L., Altieri, B., Muscogiuri, G., Laudisio, D., Annunziata, G., Colao, A., ... Savastano, S. (2018). Impact of Nutritional Status on Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) Aggressiveness. Nutrients, 10(12), doi:10.3390/nu10121854.
Barrea L, et al. Impact of Nutritional Status On Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) Aggressiveness. Nutrients. 2018 Dec 1;10(12) PubMed PMID: 30513732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Nutritional Status on Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) Aggressiveness. AU - Barrea,Luigi, AU - Altieri,Barbara, AU - Muscogiuri,Giovanna, AU - Laudisio,Daniela, AU - Annunziata,Giuseppe, AU - Colao,Annamaria, AU - Faggiano,Antongiulio, AU - Savastano,Silvia, Y1 - 2018/12/01/ PY - 2018/10/29/received PY - 2018/11/14/revised PY - 2018/11/22/accepted PY - 2018/12/6/entrez PY - 2018/12/6/pubmed PY - 2018/12/6/medline KW - Mediterranean diet KW - bioelectrical impedance analysis KW - gastroenteropancreatic neuroendocrine tumors KW - nutrition KW - tumor aggressiveness JF - Nutrients JO - Nutrients VL - 10 IS - 12 N2 - Neuroendocrine tumors (NETs) are rare neoplasms mostly originating from the gastroenteropancreatic tract (GEP-NETs). Data regarding nutritional status in GEP-NET patients are limited. The aim of the study was to investigate the nutritional status and adherence to the Mediterranean Diet (MD) in GEP-NET patients and to correlate them with tumor aggressiveness. A cross-sectional case-control observational study was conducted enrolling 83 patients with well-differentiated G1/G2 GEP-NETs after resection, as well as 83 healthy subjects, age, sex and body mass index-matched. Nutritional status was assessed by evaluating with Bioelectrical Impedance analysis and its phase angle (PhA), adherence to the MD according to PREDIMED score, dietary assessment, anthropometric parameters, and clinico-pathological characteristics. GEP-NET patients consumed less frequently vegetables, fruits, wine, fish/seafood, nuts, and more frequently red/processed meats, butter, cream, margarine, and soda drinks than controls. Patients with more aggressive disease presented a lower adherence to MD according to PREDIMED categories in comparison to G1, localized and free/stable disease status. A smaller PhA value and a lower PREDIMED score were significantly correlated with G2 tumor, metastases, and progressive disease. To the best of our knowledge, this is the first study reporting an association between nutritional status and tumor aggressiveness in a selected group of GEP-NETs. Moreover, higher intakes of food of MD, may represent a potential tool for prevention of tumor aggressiveness. Thus, a skilled nutritionist should be an integral part of the multidisciplinary management of GEP-NET patients. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30513732/Impact_of_Nutritional_Status_on_Gastroenteropancreatic_Neuroendocrine_Tumors__GEP_NET__Aggressiveness_ L2 - http://www.mdpi.com/resolver?pii=nu10121854 DB - PRIME DP - Unbound Medicine ER -