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The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review.
Nutrients. 2018 Dec 02; 10(12)N

Abstract

Chronic obstructive pulmonary disease (COPD) is a growing healthcare concern and will represent the third leading cause of death worldwide within the next decade. COPD is the result of a complex interaction between environmental factors, especially cigarette smoking, air pollution, and genetic preconditions, which result in persistent inflammation of the airways. There is growing evidence that the chronic inflammatory state, measurable by increased levels of circulating cytokines, chemokines, and acute phase proteins, may not be confined to the lungs. Cardiovascular disease (CVD) and especially coronary artery disease (CAD) are common comorbidities of COPD, and low-grade systemic inflammation plays a decisive role in its pathogenesis. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert multiple functions in humans and are crucially involved in limiting and resolving inflammatory processes. n-3 PUFAs have been intensively studied for their ability to improve morbidity and mortality in patients with CVD and CAD. This review aims to summarize the current knowledge on the effects of n-3 PUFA on inflammation and its impact on CAD in COPD from a clinical perspective.

Authors+Show Affiliations

Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria. alex.pizzini@i-med.ac.at.Department of Urology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany. lukas.lunger@tum.de.Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria. Thomas.Sonnweber@i-med.ac.at.Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria. Guenter.Weiss@i-med.ac.at.Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria. Ivan.Tancevski@i-med.ac.at.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30513804

Citation

Pizzini, Alex, et al. "The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: a Review." Nutrients, vol. 10, no. 12, 2018.
Pizzini A, Lunger L, Sonnweber T, et al. The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review. Nutrients. 2018;10(12).
Pizzini, A., Lunger, L., Sonnweber, T., Weiss, G., & Tancevski, I. (2018). The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review. Nutrients, 10(12). https://doi.org/10.3390/nu10121864
Pizzini A, et al. The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: a Review. Nutrients. 2018 Dec 2;10(12) PubMed PMID: 30513804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Omega-3 Fatty Acids in the Setting of Coronary Artery Disease and COPD: A Review. AU - Pizzini,Alex, AU - Lunger,Lukas, AU - Sonnweber,Thomas, AU - Weiss,Guenter, AU - Tancevski,Ivan, Y1 - 2018/12/02/ PY - 2018/10/11/received PY - 2018/11/09/revised PY - 2018/11/22/accepted PY - 2018/12/6/entrez PY - 2018/12/6/pubmed PY - 2019/2/1/medline KW - CAD KW - CHD KW - COPD KW - PUFA KW - coronary artery disease KW - inflammation KW - ischemic heart disease KW - n-3 PUFA KW - omega 3 JF - Nutrients JO - Nutrients VL - 10 IS - 12 N2 - Chronic obstructive pulmonary disease (COPD) is a growing healthcare concern and will represent the third leading cause of death worldwide within the next decade. COPD is the result of a complex interaction between environmental factors, especially cigarette smoking, air pollution, and genetic preconditions, which result in persistent inflammation of the airways. There is growing evidence that the chronic inflammatory state, measurable by increased levels of circulating cytokines, chemokines, and acute phase proteins, may not be confined to the lungs. Cardiovascular disease (CVD) and especially coronary artery disease (CAD) are common comorbidities of COPD, and low-grade systemic inflammation plays a decisive role in its pathogenesis. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert multiple functions in humans and are crucially involved in limiting and resolving inflammatory processes. n-3 PUFAs have been intensively studied for their ability to improve morbidity and mortality in patients with CVD and CAD. This review aims to summarize the current knowledge on the effects of n-3 PUFA on inflammation and its impact on CAD in COPD from a clinical perspective. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30513804/The_Role_of_Omega_3_Fatty_Acids_in_the_Setting_of_Coronary_Artery_Disease_and_COPD:_A_Review_ L2 - http://www.mdpi.com/resolver?pii=nu10121864 DB - PRIME DP - Unbound Medicine ER -