Tags

Type your tag names separated by a space and hit enter

Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss.
Nutrients. 2018 Dec 02; 10(12)N

Abstract

Thromboxane (TX)-dependent platelet activation and lipid peroxidation, as reflected in vivo by the urinary excretion of 11-dehydro-TXB₂ and 8-iso-prostaglandin (PG)F2α, play a key role in atherothrombosis in obesity and type 2 diabetes mellitus (T2DM) since the earlier stages. Thirty-five metformin-treated obese subjects with prediabetes or newly-diagnosed T2DM were randomized to the glucagon-like peptide receptor agonist (GLP-RA) liraglutide (1.8 mg/day) or lifestyle counseling until achieving a comparable weight loss (-7% of initial body weight), to assess whether changes in subcutaneous (SAT) and visceral (VAT) adipose tissue distribution (MRI), insulin sensitivity (Matsuda Index) and beta-cell performance (multiple sampling OGTT beta-index), with either intervention, might affect TX-dependent platelet activation, lipid peroxidation and inflammation. At baseline, Ln-8-iso-PGF2α (Beta = 0.31, p = 0.0088), glycosylated hemoglobin (HbA1c) (Beta = 2.64, p = 0.0011) Ln-TNF-α (Beta = 0.58, p = 0.0075) and SAT (Beta = 0.14, p = 0.044) were significant independent predictors of 11-dehydro-TXB₂. After achievement of the weight loss target, a comparable reduction in U-11-dehydro-TXB₂ (between-group p = 0.679) and 8-iso-PGF-2α (p = 0.985) was observed in both arms in parallel with a comparable improvement in glycemic control, insulin sensitivity, SAT, high-sensitivity C-reactive protein (hs-CRP). In obese patients with initial impairment of glucose metabolism, the extent of platelet activation is related to systemic inflammation, isoprostane formation and degree of glycemic control and abdominal SAT. Successful weight loss, achieved with either lifestyle changes or an incretin-based therapy, is associated with a significant reduction in lipid peroxidation and platelet activation.

Authors+Show Affiliations

Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI-Met), University of Chieti, 66100 Chieti, Italy. paolagsimeone@gmail.com.Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI-Met), University of Chieti, 66100 Chieti, Italy. rossellaliani@yahoo.it.Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI-Met), University of Chieti, 66100 Chieti, Italy. romina.tripaldi@hotmail.it.Department of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077 Pozzilli, Italy. dicastel@ngi.it.Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI-Met), University of Chieti, 66100 Chieti, Italy. guagnano@unich.it.Department of Neuroscience & Imaging, University of Chieti, 66100 Chieti, Italy. armando.tartaro@gmail.com.Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. bonadonna.riccardo@fastwebnet.it. Division of Endocrinology and Metabolic Diseases, Azienda Ospedaliera Universitaria of Parma, 43126 Parma, Italy. bonadonna.riccardo@fastwebnet.it.Clinical Pathology, Chieti Hospital, 66100 Chieti, Italy. virgin83@virgilio.it.Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI-Met), University of Chieti, 66100 Chieti, Italy. francesco.cipollone@unich.it.Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI-Met), University of Chieti, 66100 Chieti, Italy. consoli@unich.it.Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI-Met), University of Chieti, 66100 Chieti, Italy. francesca.santilli@unich.it.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30513818

Citation

Simeone, Paola, et al. "Thromboxane-Dependent Platelet Activation in Obese Subjects With Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss." Nutrients, vol. 10, no. 12, 2018.
Simeone P, Liani R, Tripaldi R, et al. Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss. Nutrients. 2018;10(12).
Simeone, P., Liani, R., Tripaldi, R., Di Castelnuovo, A., Guagnano, M. T., Tartaro, A., Bonadonna, R. C., Federico, V., Cipollone, F., Consoli, A., & Santilli, F. (2018). Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss. Nutrients, 10(12). https://doi.org/10.3390/nu10121872
Simeone P, et al. Thromboxane-Dependent Platelet Activation in Obese Subjects With Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss. Nutrients. 2018 Dec 2;10(12) PubMed PMID: 30513818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss. AU - Simeone,Paola, AU - Liani,Rossella, AU - Tripaldi,Romina, AU - Di Castelnuovo,Augusto, AU - Guagnano,Maria Teresa, AU - Tartaro,Armando, AU - Bonadonna,Riccardo C, AU - Federico,Virginia, AU - Cipollone,Francesco, AU - Consoli,Agostino, AU - Santilli,Francesca, Y1 - 2018/12/02/ PY - 2018/11/02/received PY - 2018/11/20/revised PY - 2018/11/26/accepted PY - 2018/12/6/entrez PY - 2018/12/6/pubmed PY - 2019/2/1/medline KW - adipose tissue distribution KW - diabetes mellitus KW - liraglutide KW - obesity KW - oxidative stress KW - platelet activation KW - weight loss JF - Nutrients JO - Nutrients VL - 10 IS - 12 N2 - Thromboxane (TX)-dependent platelet activation and lipid peroxidation, as reflected in vivo by the urinary excretion of 11-dehydro-TXB₂ and 8-iso-prostaglandin (PG)F2α, play a key role in atherothrombosis in obesity and type 2 diabetes mellitus (T2DM) since the earlier stages. Thirty-five metformin-treated obese subjects with prediabetes or newly-diagnosed T2DM were randomized to the glucagon-like peptide receptor agonist (GLP-RA) liraglutide (1.8 mg/day) or lifestyle counseling until achieving a comparable weight loss (-7% of initial body weight), to assess whether changes in subcutaneous (SAT) and visceral (VAT) adipose tissue distribution (MRI), insulin sensitivity (Matsuda Index) and beta-cell performance (multiple sampling OGTT beta-index), with either intervention, might affect TX-dependent platelet activation, lipid peroxidation and inflammation. At baseline, Ln-8-iso-PGF2α (Beta = 0.31, p = 0.0088), glycosylated hemoglobin (HbA1c) (Beta = 2.64, p = 0.0011) Ln-TNF-α (Beta = 0.58, p = 0.0075) and SAT (Beta = 0.14, p = 0.044) were significant independent predictors of 11-dehydro-TXB₂. After achievement of the weight loss target, a comparable reduction in U-11-dehydro-TXB₂ (between-group p = 0.679) and 8-iso-PGF-2α (p = 0.985) was observed in both arms in parallel with a comparable improvement in glycemic control, insulin sensitivity, SAT, high-sensitivity C-reactive protein (hs-CRP). In obese patients with initial impairment of glucose metabolism, the extent of platelet activation is related to systemic inflammation, isoprostane formation and degree of glycemic control and abdominal SAT. Successful weight loss, achieved with either lifestyle changes or an incretin-based therapy, is associated with a significant reduction in lipid peroxidation and platelet activation. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30513818/Thromboxane_Dependent_Platelet_Activation_in_Obese_Subjects_with_Prediabetes_or_Early_Type_2_Diabetes:_Effects_of_Liraglutide__or_Lifestyle_Changes_Induced_Weight_Loss_ L2 - https://www.mdpi.com/resolver?pii=nu10121872 DB - PRIME DP - Unbound Medicine ER -