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Effects of omega-3 fatty acids in hypertriglyceridemic states.
Semin Thromb Hemost. 1988 Jul; 14(3):271-84.ST

Abstract

In the experimental studies reported in this review, dietary omega-3 fatty acids from fish and fish oil had profound hypolipidemic effects in normal subjects and in hypertriglyceridemic patients with combined hyperlipidemia (type IIb) and type V hyperlipidemia. In these studies, 68 adults participated in carefully controlled metabolic experiments. In all subjects and patients, there were marked reductions in plasma cholesterol and triglyceride concentrations, with triglyceride lowering being especially great. There were also reductions in VLDL, chylomicrons, remnants, LDL, apo B, and apo E. The HDL changes were inconstant and varied from subject to subject. Whereas the mechanism of the hypolipidemic action of the omega-6-rich vegetable oils containing linoleic acid, such as corn or safflower oil, still remains obscure, the mechanism of action of the omega-3 fatty acids in fish oil has been well documented within a few years of their use as hypolipidemic agents. The synthesis of triglyceride and VLDL in the liver is greatly reduced by omega-3 fatty acids. At the same time, the turnover of VLDL in plasma is greatly shortened. LDL production is decreased. Combined with other dietary manipulations, such as a reduction in saturated fat and dietary cholesterol, the use of omega-3 fatty acids to treat hyperlipidemic and especially hypertriglyceridemic patients would appear to have a well-supported rationale. Further studies are required to delineate exact doses and precise indications for different types of hyperlipidemia and to differentiate the effects of, if any, the two major omega-3 fatty acids in fish oil, EPA and DHA. Coupled with the known antithrombotic actions of omega-3 fatty acids from fish oil because of changes in prostaglandin secretion and platelet function, these hypolipidemic effects would appear to have an important potential role in the control of coronary heart disease and other atherosclerotic disorders.

Authors+Show Affiliations

Department of Medicine, Oregon Health Sciences University, Portland 97201.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3051392

Citation

Connor, W E.. "Effects of Omega-3 Fatty Acids in Hypertriglyceridemic States." Seminars in Thrombosis and Hemostasis, vol. 14, no. 3, 1988, pp. 271-84.
Connor WE. Effects of omega-3 fatty acids in hypertriglyceridemic states. Semin Thromb Hemost. 1988;14(3):271-84.
Connor, W. E. (1988). Effects of omega-3 fatty acids in hypertriglyceridemic states. Seminars in Thrombosis and Hemostasis, 14(3), 271-84.
Connor WE. Effects of Omega-3 Fatty Acids in Hypertriglyceridemic States. Semin Thromb Hemost. 1988;14(3):271-84. PubMed PMID: 3051392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of omega-3 fatty acids in hypertriglyceridemic states. A1 - Connor,W E, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 271 EP - 84 JF - Seminars in thrombosis and hemostasis JO - Semin Thromb Hemost VL - 14 IS - 3 N2 - In the experimental studies reported in this review, dietary omega-3 fatty acids from fish and fish oil had profound hypolipidemic effects in normal subjects and in hypertriglyceridemic patients with combined hyperlipidemia (type IIb) and type V hyperlipidemia. In these studies, 68 adults participated in carefully controlled metabolic experiments. In all subjects and patients, there were marked reductions in plasma cholesterol and triglyceride concentrations, with triglyceride lowering being especially great. There were also reductions in VLDL, chylomicrons, remnants, LDL, apo B, and apo E. The HDL changes were inconstant and varied from subject to subject. Whereas the mechanism of the hypolipidemic action of the omega-6-rich vegetable oils containing linoleic acid, such as corn or safflower oil, still remains obscure, the mechanism of action of the omega-3 fatty acids in fish oil has been well documented within a few years of their use as hypolipidemic agents. The synthesis of triglyceride and VLDL in the liver is greatly reduced by omega-3 fatty acids. At the same time, the turnover of VLDL in plasma is greatly shortened. LDL production is decreased. Combined with other dietary manipulations, such as a reduction in saturated fat and dietary cholesterol, the use of omega-3 fatty acids to treat hyperlipidemic and especially hypertriglyceridemic patients would appear to have a well-supported rationale. Further studies are required to delineate exact doses and precise indications for different types of hyperlipidemia and to differentiate the effects of, if any, the two major omega-3 fatty acids in fish oil, EPA and DHA. Coupled with the known antithrombotic actions of omega-3 fatty acids from fish oil because of changes in prostaglandin secretion and platelet function, these hypolipidemic effects would appear to have an important potential role in the control of coronary heart disease and other atherosclerotic disorders. SN - 0094-6176 UR - https://www.unboundmedicine.com/medline/citation/3051392/Effects_of_omega_3_fatty_acids_in_hypertriglyceridemic_states_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1002789 DB - PRIME DP - Unbound Medicine ER -