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"Candidatus Neoehrlichia mikurensis" in Ixodes ricinus ticks collected near the Arctic Circle in Norway.
Parasit Vectors. 2018 Dec 04; 11(1):620.PV

Abstract

BACKGROUND

"Candidatus Neoehrlichia mikurensis" is a gram-negative bacterium belonging to the family Anaplasmataceae that, in Europe, is transmitted by Ixodes ricinus ticks. "Candidatus N. mikurensis" can cause a severe systemic inflammatory syndrome, neoehrlichiosis, mostly in persons with other underlying diseases. To date, "Ca. N. mikurensis" has been found in ticks in different countries in Asia and Europe, but never as far north as at the Arctic Circle.

METHODS

A total of 1104 I. ricinus ticks collected from vegetation and from animals in northern Norway (64-68°N) were analysed for the prevalence of "Ca. N. mikurensis". Of them, 495 ticks were collected from vegetation by flagging and 609 ticks were collected from dogs and cats. Total nucleic acid extracted from the ticks were converted to cDNA and analyzed with real-time PCR targeting the 16S rRNA gene of "Ca. N. mikurensis". Positive samples were further analysed by nested PCR and sequencing.

RESULTS

"Candidatus N. mikurensis" was detected in 11.2% of all collected I. ricinus ticks in northern Norway. The prevalence differed between ticks collected from vegetation (18.2%; 90/495) compared to ticks collected from dogs and cats (5.6%; 34/609). The ticks from dogs and cats were collected in Brønnøy area and seven additional districts further north. The prevalence of "Ca. N. mikurensis" in these ticks differed between geographical localities, with the highest prevalence in the Brønnøy area.

CONCLUSIONS

The detection of "Ca. N. mikurensis" in I. ricinus ticks from the Arctic Circle in northern Norway indicates potential risk for tick-bitten humans at this latitude to be infected with "Ca. N. mikurensis".

Links

PMC Free PDF

Authors+Show Affiliations

Larsson C
Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Hvidsten D
Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway. Department of Laboratory Medicine, Nordland Hospital, Bodø, Norway.
Stuen S
Department of Production Animal Clinical Sciences, Section of Small Ruminant Research and Herd Health, Norwegian University of Life Sciences, Sandnes, Norway.
Henningsson AJ
Clinical Microbiology, Laboratory Medicine, County Hospital Ryhov, Jönköping, Sweden. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Wilhelmsson P
Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. peter.wilhelmsson@liu.se. Department of Medical Microbiology, Laboratory Medicine, County Hospital Ryhov, Jönkoping, Sweden. peter.wilhelmsson@liu.se.

MeSH

AnaplasmataceaeAnaplasmataceae InfectionsAnimalsCatsDNA, BacterialDogsFemaleIxodesMaleNorwayPrevalenceRNA, Ribosomal, 16S

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30514355

Citation

Larsson, Clarinda, et al. ""Candidatus Neoehrlichia Mikurensis" in Ixodes Ricinus Ticks Collected Near the Arctic Circle in Norway." Parasites & Vectors, vol. 11, no. 1, 2018, p. 620.
Larsson C, Hvidsten D, Stuen S, et al. "Candidatus Neoehrlichia mikurensis" in Ixodes ricinus ticks collected near the Arctic Circle in Norway. Parasit Vectors. 2018;11(1):620.
Larsson, C., Hvidsten, D., Stuen, S., Henningsson, A. J., & Wilhelmsson, P. (2018). "Candidatus Neoehrlichia mikurensis" in Ixodes ricinus ticks collected near the Arctic Circle in Norway. Parasites & Vectors, 11(1), 620. https://doi.org/10.1186/s13071-018-3168-y
Larsson C, et al. "Candidatus Neoehrlichia Mikurensis" in Ixodes Ricinus Ticks Collected Near the Arctic Circle in Norway. Parasit Vectors. 2018 Dec 4;11(1):620. PubMed PMID: 30514355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - "Candidatus Neoehrlichia mikurensis" in Ixodes ricinus ticks collected near the Arctic Circle in Norway. AU - Larsson,Clarinda, AU - Hvidsten,Dag, AU - Stuen,Snorre, AU - Henningsson,Anna J, AU - Wilhelmsson,Peter, Y1 - 2018/12/04/ PY - 2018/07/20/received PY - 2018/10/25/accepted PY - 2018/12/6/entrez PY - 2018/12/6/pubmed PY - 2019/5/28/medline KW - Arctic Circle KW - Ixodes ricinus KW - Neoehrlichiosis KW - Norway KW - Tick-borne pathogen KW - “Candidatus Neoehrlichia mikurensis” SP - 620 EP - 620 JF - Parasites & vectors JO - Parasit Vectors VL - 11 IS - 1 N2 - BACKGROUND: "Candidatus Neoehrlichia mikurensis" is a gram-negative bacterium belonging to the family Anaplasmataceae that, in Europe, is transmitted by Ixodes ricinus ticks. "Candidatus N. mikurensis" can cause a severe systemic inflammatory syndrome, neoehrlichiosis, mostly in persons with other underlying diseases. To date, "Ca. N. mikurensis" has been found in ticks in different countries in Asia and Europe, but never as far north as at the Arctic Circle. METHODS: A total of 1104 I. ricinus ticks collected from vegetation and from animals in northern Norway (64-68°N) were analysed for the prevalence of "Ca. N. mikurensis". Of them, 495 ticks were collected from vegetation by flagging and 609 ticks were collected from dogs and cats. Total nucleic acid extracted from the ticks were converted to cDNA and analyzed with real-time PCR targeting the 16S rRNA gene of "Ca. N. mikurensis". Positive samples were further analysed by nested PCR and sequencing. RESULTS: "Candidatus N. mikurensis" was detected in 11.2% of all collected I. ricinus ticks in northern Norway. The prevalence differed between ticks collected from vegetation (18.2%; 90/495) compared to ticks collected from dogs and cats (5.6%; 34/609). The ticks from dogs and cats were collected in Brønnøy area and seven additional districts further north. The prevalence of "Ca. N. mikurensis" in these ticks differed between geographical localities, with the highest prevalence in the Brønnøy area. CONCLUSIONS: The detection of "Ca. N. mikurensis" in I. ricinus ticks from the Arctic Circle in northern Norway indicates potential risk for tick-bitten humans at this latitude to be infected with "Ca. N. mikurensis". SN - 1756-3305 UR - https://www.unboundmedicine.com/medline/citation/30514355/"Candidatus_Neoehrlichia_mikurensis"_in_Ixodes_ricinus_ticks_collected_near_the_Arctic_Circle_in_Norway_ DB - PRIME DP - Unbound Medicine ER -