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Patient Survival After Acute Voluntary Poisoning With a Huge Dose of Oxcarbazepine and Olanzapine.
Med Arch. 2018 Oct; 72(4):303-305.MA

Abstract

Introduction

Oxcarbazepine is a carbamazepine pre-drug with less drug interactions. Its adverse effects, including hyponatremia, somnolence and ataxia, are dose dependent. Olanzapine is an atypical antipsychotic drug most commonly used to manage psychoses and symptoms of irritability and aggressive behavior. Main side effects include extrapyramidal and anticholinergic symptoms, weight gain, and hyperglycemia.

Case Report

In this manuscript a case of oxcarbazepine and olanzapine intoxication is discussed. A 45-year-old woman, previously diagnosed with bipolar disorder and chronic alcoholism, was presented two hours after ingestion of 30,000mg of oxcarbazepine and 140 mg of olanzapine, combined with alcohol. She was immediately treated with gastric lavage and administration of activated charcoal. During her hospitalization she was hemodynamically and respiratory stable with no neurological signs and symptoms except for somnolence. Another side effect was hyponatremia. She was discharged from our department in stable clinical condition after being evaluated by a psychiatrist.

Conclusion

Early approach is crucial for the management of drug intoxication. Late symptoms can be avoided through close monitoring of vital signs, mental status and laboratory values. Psychiatric consultation is essential for a better long-term outcome.

Authors+Show Affiliations

Department of Internal Medicine, Amalia Fleming General Hospital, Athens, 15127, Greece.Department of Internal Medicine, Amalia Fleming General Hospital, Athens, 15127, Greece.Department of Internal Medicine, Amalia Fleming General Hospital, Athens, 15127, Greece.Department of Internal Medicine, Amalia Fleming General Hospital, Athens, 15127, Greece.Department of Internal Medicine, Amalia Fleming General Hospital, Athens, 15127, Greece.Department of Internal Medicine, Amalia Fleming General Hospital, Athens, 15127, Greece.Department of Internal Medicine, Amalia Fleming General Hospital, Athens, 15127, Greece.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30515002

Citation

Kalogera, Vasiliki, et al. "Patient Survival After Acute Voluntary Poisoning With a Huge Dose of Oxcarbazepine and Olanzapine." Medical Archives (Sarajevo, Bosnia and Herzegovina), vol. 72, no. 4, 2018, pp. 303-305.
Kalogera V, Galopoulos D, Eleftheriotis G, et al. Patient Survival After Acute Voluntary Poisoning With a Huge Dose of Oxcarbazepine and Olanzapine. Med Arch. 2018;72(4):303-305.
Kalogera, V., Galopoulos, D., Eleftheriotis, G., Meimeti, E., Malios, I., Marathonitis, G., & Loupa, C. (2018). Patient Survival After Acute Voluntary Poisoning With a Huge Dose of Oxcarbazepine and Olanzapine. Medical Archives (Sarajevo, Bosnia and Herzegovina), 72(4), 303-305. https://doi.org/10.5455/medarh.2018.72.303-305
Kalogera V, et al. Patient Survival After Acute Voluntary Poisoning With a Huge Dose of Oxcarbazepine and Olanzapine. Med Arch. 2018;72(4):303-305. PubMed PMID: 30515002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patient Survival After Acute Voluntary Poisoning With a Huge Dose of Oxcarbazepine and Olanzapine. AU - Kalogera,Vasiliki, AU - Galopoulos,Dimitrios, AU - Eleftheriotis,Gerasimos, AU - Meimeti,Evangelia, AU - Malios,Ioannis, AU - Marathonitis,Georgios, AU - Loupa,Chariclia, PY - 2018/12/6/entrez PY - 2018/12/6/pubmed PY - 2019/4/23/medline KW - bipolar disease KW - intoxication KW - olanzapine KW - oxcarbazepine KW - poisoning KW - suicide attempt KW - voluntary SP - 303 EP - 305 JF - Medical archives (Sarajevo, Bosnia and Herzegovina) JO - Med Arch VL - 72 IS - 4 N2 - Introduction: Oxcarbazepine is a carbamazepine pre-drug with less drug interactions. Its adverse effects, including hyponatremia, somnolence and ataxia, are dose dependent. Olanzapine is an atypical antipsychotic drug most commonly used to manage psychoses and symptoms of irritability and aggressive behavior. Main side effects include extrapyramidal and anticholinergic symptoms, weight gain, and hyperglycemia. Case Report: In this manuscript a case of oxcarbazepine and olanzapine intoxication is discussed. A 45-year-old woman, previously diagnosed with bipolar disorder and chronic alcoholism, was presented two hours after ingestion of 30,000mg of oxcarbazepine and 140 mg of olanzapine, combined with alcohol. She was immediately treated with gastric lavage and administration of activated charcoal. During her hospitalization she was hemodynamically and respiratory stable with no neurological signs and symptoms except for somnolence. Another side effect was hyponatremia. She was discharged from our department in stable clinical condition after being evaluated by a psychiatrist. Conclusion: Early approach is crucial for the management of drug intoxication. Late symptoms can be avoided through close monitoring of vital signs, mental status and laboratory values. Psychiatric consultation is essential for a better long-term outcome. SN - 1986-5961 UR - https://www.unboundmedicine.com/medline/citation/30515002/Patient_Survival_After_Acute_Voluntary_Poisoning_With_a_Huge_Dose_of_Oxcarbazepine_and_Olanzapine_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30515002/ DB - PRIME DP - Unbound Medicine ER -