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Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica.
Nat Prod Commun. 2017 Apr; 12(4):491-493.NP

Abstract

A new monoterpenoid indole alkaloid, ochroborbone (1), along with five known alkaloids (2-6), were isolated from the stems and leaves of Ochrosia borbonica. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time-These structures were established on the basis of extensive spectroscopic methods. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1 and 2 exhibited inhibitory effects with IC₅₀ values comparable with those of cisplatin.

Authors

Liu VP
No affiliation info available
Chen AH
No affiliation info available
Li RH
No affiliation info available
Yang HW
No affiliation info available
Bao HN
No affiliation info available
Lai L
No affiliation info available
Zong K
No affiliation info available
Fu VH
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalHumansIndole AlkaloidsOchrosiaPlant ExtractsPlant Leaves

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30520579

Citation

Liu, Van-Ping, et al. "Ochroborbone, a New Cytotoxic Indole Alkaloid From Ochrosia Borbonica." Natural Product Communications, vol. 12, no. 4, 2017, pp. 491-493.
Liu VP, Chen AH, Li RH, et al. Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica. Nat Prod Commun. 2017;12(4):491-493.
Liu, V. P., Chen, A. H., Li, R. H., Yang, H. W., Bao, H. N., Lai, L., Zong, K., & Fu, V. H. (2017). Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica. Natural Product Communications, 12(4), 491-493.
Liu VP, et al. Ochroborbone, a New Cytotoxic Indole Alkaloid From Ochrosia Borbonica. Nat Prod Commun. 2017;12(4):491-493. PubMed PMID: 30520579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica. AU - Liu,Van-Ping, AU - Chen,A-Hong, AU - Li,Ruo-Heng, AU - Yang,Hui-Wen, AU - Bao,Hai-Nan, AU - Lai,Liang, AU - Zong,Kang, AU - Fu,Van-Hui, PY - 2018/12/7/entrez PY - 2017/4/1/pubmed PY - 2019/3/29/medline SP - 491 EP - 493 JF - Natural product communications JO - Nat Prod Commun VL - 12 IS - 4 N2 - A new monoterpenoid indole alkaloid, ochroborbone (1), along with five known alkaloids (2-6), were isolated from the stems and leaves of Ochrosia borbonica. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time-These structures were established on the basis of extensive spectroscopic methods. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1 and 2 exhibited inhibitory effects with IC₅₀ values comparable with those of cisplatin. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/30520579/Ochroborbone_A_New_Cytotoxic_Indole_Alkaloid_from_Ochrosia_borbonica_ DB - PRIME DP - Unbound Medicine ER -