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Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease.
PLoS One 2018; 13(12):e0207843Plos

Abstract

AIMS

To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset.

METHODS

We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Hyperfiltration was defined as eGFR (CKD-EPI equation) exceeding the age- and sex-specific 95th percentile for healthy control subjects.

RESULTS

Prevalence of hyperfiltration was 5.2% and that among normal, prediabetic, and diabetic subjects was 4.9%, 5.6%, and 7.3%, respectively, after adjusting for age, sex, and body weight (p for trend = 0.008). In a multiple logistic regression analysis, hyperfiltration was associated with a body mass index ≥30 kg/m2 [odds ratio (OR) = 3.461, p<0.001], waist circumference 85 cm (men) or 80 cm (women) (OR = 1.425, p = 0.015), systolic blood pressure 120-129 mmHg (OR = 1.644, p = 0.022), fasting plasma glucose 140 mg/dL (OR = 1.695, p = 0.033) and t serum triglyceride level 500 mg/dL (OR = 2.988, p = 0.001), and was independently associated with the ACR (B = 0.053, p<0.001).

CONCLUSIONS

In a general Korean population, both hyperfiltration and ACR were associated with similar metabolic parameters, and hyperfiltration correlated independently with a high ACR. Longitudinal studies are needed to further explore risks of hyperfiltration and microalbuminuria.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.Division of Endocrinology and Metabolism, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Republic of Korea.Department of Endocrinology and Metabolism, Division of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Republic of Korea.Division of Endocrinology Metabolism and Geriatric Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30521539

Citation

Hong, Sangmo, et al. "Association Between Metabolic Parameters and Glomerular Hyperfiltration in a Representative Korean Population Without Chronic Kidney Disease." PloS One, vol. 13, no. 12, 2018, pp. e0207843.
Hong S, Choi YM, Ihm SH, et al. Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease. PLoS ONE. 2018;13(12):e0207843.
Hong, S., Choi, Y. M., Ihm, S. H., Kim, D., Choi, M. G., Yu, J. M., & Hong, E. G. (2018). Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease. PloS One, 13(12), pp. e0207843. doi:10.1371/journal.pone.0207843.
Hong S, et al. Association Between Metabolic Parameters and Glomerular Hyperfiltration in a Representative Korean Population Without Chronic Kidney Disease. PLoS ONE. 2018;13(12):e0207843. PubMed PMID: 30521539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease. AU - Hong,Sangmo, AU - Choi,Yun Mi, AU - Ihm,Sung-Hee, AU - Kim,Dooman, AU - Choi,Moon-Gi, AU - Yu,Jae Myung, AU - Hong,Eun-Gyoung, Y1 - 2018/12/06/ PY - 2018/06/20/received PY - 2018/11/07/accepted PY - 2018/12/7/entrez PY - 2018/12/7/pubmed PY - 2019/5/7/medline SP - e0207843 EP - e0207843 JF - PloS one JO - PLoS ONE VL - 13 IS - 12 N2 - AIMS: To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset. METHODS: We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Hyperfiltration was defined as eGFR (CKD-EPI equation) exceeding the age- and sex-specific 95th percentile for healthy control subjects. RESULTS: Prevalence of hyperfiltration was 5.2% and that among normal, prediabetic, and diabetic subjects was 4.9%, 5.6%, and 7.3%, respectively, after adjusting for age, sex, and body weight (p for trend = 0.008). In a multiple logistic regression analysis, hyperfiltration was associated with a body mass index ≥30 kg/m2 [odds ratio (OR) = 3.461, p<0.001], waist circumference 85 cm (men) or 80 cm (women) (OR = 1.425, p = 0.015), systolic blood pressure 120-129 mmHg (OR = 1.644, p = 0.022), fasting plasma glucose 140 mg/dL (OR = 1.695, p = 0.033) and t serum triglyceride level 500 mg/dL (OR = 2.988, p = 0.001), and was independently associated with the ACR (B = 0.053, p<0.001). CONCLUSIONS: In a general Korean population, both hyperfiltration and ACR were associated with similar metabolic parameters, and hyperfiltration correlated independently with a high ACR. Longitudinal studies are needed to further explore risks of hyperfiltration and microalbuminuria. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/30521539/Association_between_metabolic_parameters_and_glomerular_hyperfiltration_in_a_representative_Korean_population_without_chronic_kidney_disease_ L2 - http://dx.plos.org/10.1371/journal.pone.0207843 DB - PRIME DP - Unbound Medicine ER -