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The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis.
J Neurol Sci. 2019 01 15; 396:225-231.JN

Abstract

BACKGROUND AND OBJECTIVE

Adult demyelinating optic neuritis (ON) with positive myelin-oligodendrocyte glycoprotein antibody (MOG-Ab) has distinct clinical features. This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON.

METHODS

Clinical data analysis was undertaken in adults with ON admitted between December 2014 and January 2016. Patients were classified into three groups based on aquaporin-4 antibody (AQP4-Ab) and MOG-Ab status: AQP4-ON, MOG-ON and seronegative-ON.

RESULTS

A total of 158 adults with ON (190 eyes) were assessed, including 31 MOG-ON (19.6%), 67 AQP4-ON (42.4%) and 60 seronegative-ON (38.0%) cases. The female-to-male ratio was significantly lower in MOG-ON (1.8:1) than that in AQP4-ON (8.6:1) groups (p = .005). The median age, percentage of bilateral ON and visual loss at the nadir at onset was similar among the three groups. Thirty-eight eyes (76%) in the MOG-ON group showed good visual recovery (>20/40) in the final visit, which is statistically better than that in the AQP4-ON and seronegative-ON groups (p < .001 and p = .006, resoectively). Fifteen adults with ON (9.5%) showed dependency on steroid, which was particularly prominent in the MOG-ON group (11/31, 35.5%) and rarely presented in the AQP4-ON (2, 3.0%) and seronegative-ON (2, 3.3%) groups. Results suggested less loss of pRNFL in MOG-ON than that in AQP4-ON group (p < .001), and a larger proportion of canalicular segment involved in MOG-ON adults (p = .007 and p < .001).

CONCLUSION

MOG-ON had the smallest proportion of acute demyelinating ON in Chinese adults. One third of adults with MOG-ON predominantly showed a substantial dependency on steroids and relapse on steroid reduction or cessation, which rarely presented in AQP4-ON and seronegative-ON adults.

Authors+Show Affiliations

Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China.Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China.Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China.Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China.Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China.Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China.Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China.Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China. Electronic address: weishihui706@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30522039

Citation

Liu, Hongjuan, et al. "The Prevalence and Prognostic Value of Myelin Oligodendrocyte Glycoprotein Antibody in Adult Optic Neuritis." Journal of the Neurological Sciences, vol. 396, 2019, pp. 225-231.
Liu H, Zhou H, Wang J, et al. The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis. J Neurol Sci. 2019;396:225-231.
Liu, H., Zhou, H., Wang, J., Sun, M., Teng, D., Song, H., Xu, Q., & Wei, S. (2019). The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis. Journal of the Neurological Sciences, 396, 225-231. https://doi.org/10.1016/j.jns.2018.11.029
Liu H, et al. The Prevalence and Prognostic Value of Myelin Oligodendrocyte Glycoprotein Antibody in Adult Optic Neuritis. J Neurol Sci. 2019 01 15;396:225-231. PubMed PMID: 30522039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis. AU - Liu,Hongjuan, AU - Zhou,Huanfen, AU - Wang,Junqing, AU - Sun,Mingming, AU - Teng,Da, AU - Song,Honglu, AU - Xu,Quangang, AU - Wei,Shihui, Y1 - 2018/11/28/ PY - 2018/07/05/received PY - 2018/11/13/revised PY - 2018/11/26/accepted PY - 2018/12/7/pubmed PY - 2019/7/23/medline PY - 2018/12/7/entrez KW - Myelin-oligodendrocyte glycoprotein (MOG) KW - Optic neuritis KW - Prevalence KW - Steroid-dependency SP - 225 EP - 231 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 396 N2 - BACKGROUND AND OBJECTIVE: Adult demyelinating optic neuritis (ON) with positive myelin-oligodendrocyte glycoprotein antibody (MOG-Ab) has distinct clinical features. This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON. METHODS: Clinical data analysis was undertaken in adults with ON admitted between December 2014 and January 2016. Patients were classified into three groups based on aquaporin-4 antibody (AQP4-Ab) and MOG-Ab status: AQP4-ON, MOG-ON and seronegative-ON. RESULTS: A total of 158 adults with ON (190 eyes) were assessed, including 31 MOG-ON (19.6%), 67 AQP4-ON (42.4%) and 60 seronegative-ON (38.0%) cases. The female-to-male ratio was significantly lower in MOG-ON (1.8:1) than that in AQP4-ON (8.6:1) groups (p = .005). The median age, percentage of bilateral ON and visual loss at the nadir at onset was similar among the three groups. Thirty-eight eyes (76%) in the MOG-ON group showed good visual recovery (>20/40) in the final visit, which is statistically better than that in the AQP4-ON and seronegative-ON groups (p < .001 and p = .006, resoectively). Fifteen adults with ON (9.5%) showed dependency on steroid, which was particularly prominent in the MOG-ON group (11/31, 35.5%) and rarely presented in the AQP4-ON (2, 3.0%) and seronegative-ON (2, 3.3%) groups. Results suggested less loss of pRNFL in MOG-ON than that in AQP4-ON group (p < .001), and a larger proportion of canalicular segment involved in MOG-ON adults (p = .007 and p < .001). CONCLUSION: MOG-ON had the smallest proportion of acute demyelinating ON in Chinese adults. One third of adults with MOG-ON predominantly showed a substantial dependency on steroids and relapse on steroid reduction or cessation, which rarely presented in AQP4-ON and seronegative-ON adults. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/30522039/The_prevalence_and_prognostic_value_of_myelin_oligodendrocyte_glycoprotein_antibody_in_adult_optic_neuritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(18)30482-9 DB - PRIME DP - Unbound Medicine ER -