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Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy.
J Transl Med. 2018 12 06; 16(1):343.JT

Abstract

BACKGROUND

The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART.

METHODS

This is a retrospective study of 324 naïve cART patients with CD4+ < 200 cells/mm3, who were followed-up during 24 months after initiating cART. All patients had undetectable HIV viral load during the follow-up. Besides, we included 141 healthy controls. MtDNA genotyping was performed by using Sequenom's MassARRAY platform. The primary outcome variable was the slope of CD4+ recovery. Patients were stratified into two groups by the median slope value of CD4+ (9.65 CD4+ cells/mm3/month). Logistic regression analyses were performed to calculate the odds of CD4+ recovery according to mtDNA haplogroups.

RESULTS

Our study included European HIV-infected patients within the N macro-cluster. The baseline values of CD4+ T-cells were similar between groups of patients stratified by the P50th of the slope of CD4+ T-cells recovery. Patients in the low CD4+ T-cells recovery group were older (p = 0.001), but this variable was included in the multivariate models. When we analyzed the frequencies of mtDNA haplogroups, no significant differences between HIV-infected individuals and healthy controls were found. We did not find any significant association between mtDNA haplogroups and the slope of CD4+ T-cells recovery by linear regression analysis. However, Patients carrying haplogroup H had a higher odds of having a better CD4+ recovery (> 9.65 CD4+ cells/mm3/month) than patients without haplogroup H (p = 0.032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9.65 CD4+ cells/mm3/month [adjusted odds ratio (aOR) = 1.75 (95% CI = 1.04; 2.95); p = 0.035].

CONCLUSIONS

European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV-infected patients starting cART with CD4+ < 200 cells/mm3.

Authors+Show Affiliations

Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2.2, 28220, Majadahonda, Madrid, Spain.Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2.2, 28220, Majadahonda, Madrid, Spain.Institut de Recerca de la Sida IrsiCaixa-HIVACAT, Badalona, Barcelona, Spain. Institut d'investigació en Ciènces de la Salut Germans Trias i Pujol, Universitat Autónoma de Barcelona, Badalona, Barcelona, Spain.Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Av. Reyes Católicos, 2, 28040, Madrid, Spain. Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain.Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2.2, 28220, Majadahonda, Madrid, Spain.Laboratorio de Immunobiología, Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. UGC Clinical Laboratories, Hospital Universitario Virgen del Rocío, Seville, Spain.Hospital Universitario y Politécnico de La Fe, Valencia, Spain.Hospital Universitario Donostia, San Sebastián, Spain.Hospital General Universitario Reina Sofía, Murcia, Spain.Hospital General Universitario Santa Lucía, Cartagena, Spain.Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Av. Reyes Católicos, 2, 28040, Madrid, Spain. jbenito1@hotmail.com. Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain. jbenito1@hotmail.com.Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Av. Reyes Católicos, 2, 28040, Madrid, Spain. Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain.Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2.2, 28220, Majadahonda, Madrid, Spain. sresino@isciii.es.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30522500

Citation

Medrano, Luz M., et al. "Mitochondrial Haplogroup H Is Related to CD4+ T Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy." Journal of Translational Medicine, vol. 16, no. 1, 2018, p. 343.
Medrano LM, Gutiérrez-Rivas M, Blanco J, et al. Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy. J Transl Med. 2018;16(1):343.
Medrano, L. M., Gutiérrez-Rivas, M., Blanco, J., García, M., Jiménez-Sousa, M. A., Pacheco, Y. M., Montero, M., Iribarren, J. A., Bernal, E., Martínez, O. J., Benito, J. M., Rallón, N., & Resino, S. (2018). Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy. Journal of Translational Medicine, 16(1), 343. https://doi.org/10.1186/s12967-018-1717-y
Medrano LM, et al. Mitochondrial Haplogroup H Is Related to CD4+ T Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy. J Transl Med. 2018 12 6;16(1):343. PubMed PMID: 30522500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy. AU - Medrano,Luz M, AU - Gutiérrez-Rivas,Mónica, AU - Blanco,Julià, AU - García,Marcial, AU - Jiménez-Sousa,María A, AU - Pacheco,Yolanda M, AU - Montero,Marta, AU - Iribarren,José Antonio, AU - Bernal,Enrique, AU - Martínez,Onofre Juan, AU - Benito,José M, AU - Rallón,Norma, AU - Resino,Salvador, AU - ,, Y1 - 2018/12/06/ PY - 2018/07/24/received PY - 2018/12/02/accepted PY - 2018/12/8/entrez PY - 2018/12/14/pubmed PY - 2019/6/22/medline KW - HIV KW - Haplogroups KW - Immune reconstitution KW - Mitochondria KW - cART KW - mtDNA SP - 343 EP - 343 JF - Journal of translational medicine JO - J Transl Med VL - 16 IS - 1 N2 - BACKGROUND: The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. METHODS: This is a retrospective study of 324 naïve cART patients with CD4+ < 200 cells/mm3, who were followed-up during 24 months after initiating cART. All patients had undetectable HIV viral load during the follow-up. Besides, we included 141 healthy controls. MtDNA genotyping was performed by using Sequenom's MassARRAY platform. The primary outcome variable was the slope of CD4+ recovery. Patients were stratified into two groups by the median slope value of CD4+ (9.65 CD4+ cells/mm3/month). Logistic regression analyses were performed to calculate the odds of CD4+ recovery according to mtDNA haplogroups. RESULTS: Our study included European HIV-infected patients within the N macro-cluster. The baseline values of CD4+ T-cells were similar between groups of patients stratified by the P50th of the slope of CD4+ T-cells recovery. Patients in the low CD4+ T-cells recovery group were older (p = 0.001), but this variable was included in the multivariate models. When we analyzed the frequencies of mtDNA haplogroups, no significant differences between HIV-infected individuals and healthy controls were found. We did not find any significant association between mtDNA haplogroups and the slope of CD4+ T-cells recovery by linear regression analysis. However, Patients carrying haplogroup H had a higher odds of having a better CD4+ recovery (> 9.65 CD4+ cells/mm3/month) than patients without haplogroup H (p = 0.032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9.65 CD4+ cells/mm3/month [adjusted odds ratio (aOR) = 1.75 (95% CI = 1.04; 2.95); p = 0.035]. CONCLUSIONS: European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV-infected patients starting cART with CD4+ < 200 cells/mm3. SN - 1479-5876 UR - https://www.unboundmedicine.com/medline/citation/30522500/Mitochondrial_haplogroup_H_is_related_to_CD4+_T_cell_recovery_in_HIV_infected_patients_starting_combination_antiretroviral_therapy_ L2 - https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1717-y DB - PRIME DP - Unbound Medicine ER -