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Advances in transdermal insulin delivery.
Adv Drug Deliv Rev. 2019 01 15; 139:51-70.AD

Abstract

Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years. Transdermal systems designed to prevent insulin degradation and offer controlled, sustained release of insulin may be desirable for patients and lead to increased adherence and glycemic outcomes. A challenge for transdermal insulin delivery is the inefficient passive insulin absorption through the skin due to the large molecular weight of the protein drug. In this review, we focus on the different transdermal insulin delivery techniques and their respective advantages and limitations, including chemical enhancers-promoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods.

Authors+Show Affiliations

Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; California NanoSystems Institute, Jonsson Comprehensive Cancer Center, Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA 90095, USA. Electronic address: guzhen@ucla.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

30528729

Citation

Zhang, Yuqi, et al. "Advances in Transdermal Insulin Delivery." Advanced Drug Delivery Reviews, vol. 139, 2019, pp. 51-70.
Zhang Y, Yu J, Kahkoska AR, et al. Advances in transdermal insulin delivery. Adv Drug Deliv Rev. 2019;139:51-70.
Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z. (2019). Advances in transdermal insulin delivery. Advanced Drug Delivery Reviews, 139, 51-70. https://doi.org/10.1016/j.addr.2018.12.006
Zhang Y, et al. Advances in Transdermal Insulin Delivery. Adv Drug Deliv Rev. 2019 01 15;139:51-70. PubMed PMID: 30528729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in transdermal insulin delivery. AU - Zhang,Yuqi, AU - Yu,Jicheng, AU - Kahkoska,Anna R, AU - Wang,Jinqiang, AU - Buse,John B, AU - Gu,Zhen, Y1 - 2018/12/08/ PY - 2018/06/29/received PY - 2018/11/06/revised PY - 2018/12/05/accepted PY - 2018/12/12/pubmed PY - 2020/2/25/medline PY - 2018/12/12/entrez KW - Diabetes KW - Drug delivery KW - Electroporation KW - Insulin KW - Iontophoresis KW - Jet injection KW - Microneedle KW - Transdermal delivery KW - Ultrasound SP - 51 EP - 70 JF - Advanced drug delivery reviews JO - Adv. Drug Deliv. Rev. VL - 139 N2 - Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years. Transdermal systems designed to prevent insulin degradation and offer controlled, sustained release of insulin may be desirable for patients and lead to increased adherence and glycemic outcomes. A challenge for transdermal insulin delivery is the inefficient passive insulin absorption through the skin due to the large molecular weight of the protein drug. In this review, we focus on the different transdermal insulin delivery techniques and their respective advantages and limitations, including chemical enhancers-promoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods. SN - 1872-8294 UR - https://www.unboundmedicine.com/medline/citation/30528729/Advances_in_transdermal_insulin_delivery L2 - https://linkinghub.elsevier.com/retrieve/pii/S0169-409X(18)30309-0 DB - PRIME DP - Unbound Medicine ER -