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Quantification of Cerebellar Crowding in Type I Chiari Malformation.
Ann Biomed Eng. 2019 Mar; 47(3):731-743.AB

Abstract

This study was focused on a semi-automated morphometric analysis of the cerebellum in the mid-sagittal plane as an alternative to tonsillar descent alone in the evaluation of Chiari malformation type 1 (CMI) patients. Morphometric analyses of posterior fossa structures were performed on mid-sagittal MRI images of 375 individuals (females, > 18 years, 235 CMI and 140 healthy controls). Twenty-six parameters including linear, angular and area measurements together with non-dimensional ratios were calculated. Eighteen parameters were found to be significantly different between CMI and control subjects. Smaller posterior cranial fossa (PCF) area in CMI subjects was attributed to a smaller PCF area anterior to the brainstem. The cerebellar area was found to be larger in CMI subjects as compared to controls (15.1%), even without inclusion of the tonsillar area below the foramen magnum (FM) (8.4%). The larger cerebellar area in CMI subjects was due to cranial-caudal elongation of the cerebellum, predominately below the fastigium. The cerebrospinal fluid spaces below the FM were smaller in CMI subjects as compared to controls. Overall, greater cerebellar crowding was identified in CMI subjects relative to healthy controls. These observations may improve our understanding of the pathophysiology of CMI in adult female patients.

Authors+Show Affiliations

Department of Mechanical Engineering, The University of Akron, Akron, OH, 44325-3903, USA. db76@uakron.edu.Department of Biomedical Engineering, The University of Akron, Akron, OH, USA.Department of Psychology, Middle Tennessee State University, Murfreesboro, TN, USA.Department of Mechanical Engineering, The University of Akron, Akron, OH, 44325-3903, USA.Department of Radiology, University of Michigan Health System, Ann Arbor, MI, USA.Conquer Chiari, Wexford, PA, USA.Department of Psychology, The University of Akron, Akron, OH, USA.Department of Neurology, The University of Chicago Medicine, Chicago, IL, USA.Department of Mechanical Engineering, The University of Akron, Akron, OH, 44325-3903, USA. Department of Biomedical Engineering, The University of Akron, Akron, OH, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30535814

Citation

Biswas, Dipankar, et al. "Quantification of Cerebellar Crowding in Type I Chiari Malformation." Annals of Biomedical Engineering, vol. 47, no. 3, 2019, pp. 731-743.
Biswas D, Eppelheimer MS, Houston JR, et al. Quantification of Cerebellar Crowding in Type I Chiari Malformation. Ann Biomed Eng. 2019;47(3):731-743.
Biswas, D., Eppelheimer, M. S., Houston, J. R., Ibrahimy, A., Bapuraj, J. R., Labuda, R., Allen, P. A., Frim, D., & Loth, F. (2019). Quantification of Cerebellar Crowding in Type I Chiari Malformation. Annals of Biomedical Engineering, 47(3), 731-743. https://doi.org/10.1007/s10439-018-02175-z
Biswas D, et al. Quantification of Cerebellar Crowding in Type I Chiari Malformation. Ann Biomed Eng. 2019;47(3):731-743. PubMed PMID: 30535814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of Cerebellar Crowding in Type I Chiari Malformation. AU - Biswas,Dipankar, AU - Eppelheimer,Maggie S, AU - Houston,James R, AU - Ibrahimy,Alaaddin, AU - Bapuraj,J Rajiv, AU - Labuda,Richard, AU - Allen,Philip A, AU - Frim,David, AU - Loth,Francis, Y1 - 2018/12/07/ PY - 2018/06/11/received PY - 2018/11/24/accepted PY - 2018/12/12/pubmed PY - 2019/6/30/medline PY - 2018/12/12/entrez KW - Cerebrospinal fluid KW - MRI KW - Morphology KW - Posterior cranial fossa KW - Tonsillar position SP - 731 EP - 743 JF - Annals of biomedical engineering JO - Ann Biomed Eng VL - 47 IS - 3 N2 - This study was focused on a semi-automated morphometric analysis of the cerebellum in the mid-sagittal plane as an alternative to tonsillar descent alone in the evaluation of Chiari malformation type 1 (CMI) patients. Morphometric analyses of posterior fossa structures were performed on mid-sagittal MRI images of 375 individuals (females, > 18 years, 235 CMI and 140 healthy controls). Twenty-six parameters including linear, angular and area measurements together with non-dimensional ratios were calculated. Eighteen parameters were found to be significantly different between CMI and control subjects. Smaller posterior cranial fossa (PCF) area in CMI subjects was attributed to a smaller PCF area anterior to the brainstem. The cerebellar area was found to be larger in CMI subjects as compared to controls (15.1%), even without inclusion of the tonsillar area below the foramen magnum (FM) (8.4%). The larger cerebellar area in CMI subjects was due to cranial-caudal elongation of the cerebellum, predominately below the fastigium. The cerebrospinal fluid spaces below the FM were smaller in CMI subjects as compared to controls. Overall, greater cerebellar crowding was identified in CMI subjects relative to healthy controls. These observations may improve our understanding of the pathophysiology of CMI in adult female patients. SN - 1573-9686 UR - https://www.unboundmedicine.com/medline/citation/30535814/Quantification_of_Cerebellar_Crowding_in_Type_I_Chiari_Malformation_ L2 - https://doi.org/10.1007/s10439-018-02175-z DB - PRIME DP - Unbound Medicine ER -