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Assessment of within-breath impulse oscillometry parameters in children with asthma.
Pediatr Pulmonol. 2019 02; 54(2):117-124.PP

Abstract

BACKGROUND

Impulse oscillometry (IOS) measures respiratory resistance and reactance during tidal breaths and is a convenient tool for evaluation of lung function. Respiratory resistance and reactance can be measured separately during inspiration and expiration (inspiratory-expiratory analysis).

OBJECTIVE

We investigated the differences in inspiratory-expiratory measurements obtained using IOS between children with and without asthma.

METHODS

We analyzed 819 subjects aged 4-18 years, including asthmatic children (n = 600) and controls (n = 219). Asthma was diagnosed in accordance with the American Thoracic Society/European Respiratory Society guideline. Spirometry and IOS were performed in all subjects.

RESULTS

In whole-breath analysis, the asthma group had higher resistance at 5 Hz (R5) and reactance area (AX) and lower reactance at 5 Hz (X5) than the control groups. In inspiratory-expiratory analysis, the asthma group showed increased expiratory R5 and AX and decreased expiratory X5 when compared with the control group. The absolute changes in R5, X5, and AX values between inspiration and expiration were greater in children with asthma than those in controls (0.138 ± 0.195 vs 0.102 ± 0.162, P = 0.014; -0.106 ± 0.200 vs -0.086 ± 0.434, P < 0.001 and 0.460 ± 11.63 vs 0.398 ± 2.88, P = 0.002, respectively).

CONCLUSIONS

Inspiratory-expiratory IOS analysis differentiated asthmatic children from control subjects, reflecting airway narrowing on expiration in pediatric asthma. The changes in R5, X5, and AX between inspiration and expiration can be a useful index for diagnosis of asthma in children without assessment of the response to a bronchodilator.

Authors+Show Affiliations

Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30536749

Citation

Sol, In Suk, et al. "Assessment of Within-breath Impulse Oscillometry Parameters in Children With Asthma." Pediatric Pulmonology, vol. 54, no. 2, 2019, pp. 117-124.
Sol IS, Kim YH, Kim S, et al. Assessment of within-breath impulse oscillometry parameters in children with asthma. Pediatr Pulmonol. 2019;54(2):117-124.
Sol, I. S., Kim, Y. H., Kim, S., Kim, J. D., Choi, S. H., Kim, K. W., & Sohn, M. H. (2019). Assessment of within-breath impulse oscillometry parameters in children with asthma. Pediatric Pulmonology, 54(2), 117-124. https://doi.org/10.1002/ppul.24201
Sol IS, et al. Assessment of Within-breath Impulse Oscillometry Parameters in Children With Asthma. Pediatr Pulmonol. 2019;54(2):117-124. PubMed PMID: 30536749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of within-breath impulse oscillometry parameters in children with asthma. AU - Sol,In Suk, AU - Kim,Yoon Hee, AU - Kim,SooYeon, AU - Kim,Jong Deok, AU - Choi,Sun Ha, AU - Kim,Kyung Won, AU - Sohn,Myung Hyun, Y1 - 2018/12/10/ PY - 2017/11/13/received PY - 2018/10/12/accepted PY - 2018/12/12/pubmed PY - 2020/1/29/medline PY - 2018/12/12/entrez KW - asthma KW - impulse oscillometry KW - within-breath analysis SP - 117 EP - 124 JF - Pediatric pulmonology JO - Pediatr. Pulmonol. VL - 54 IS - 2 N2 - BACKGROUND: Impulse oscillometry (IOS) measures respiratory resistance and reactance during tidal breaths and is a convenient tool for evaluation of lung function. Respiratory resistance and reactance can be measured separately during inspiration and expiration (inspiratory-expiratory analysis). OBJECTIVE: We investigated the differences in inspiratory-expiratory measurements obtained using IOS between children with and without asthma. METHODS: We analyzed 819 subjects aged 4-18 years, including asthmatic children (n = 600) and controls (n = 219). Asthma was diagnosed in accordance with the American Thoracic Society/European Respiratory Society guideline. Spirometry and IOS were performed in all subjects. RESULTS: In whole-breath analysis, the asthma group had higher resistance at 5 Hz (R5) and reactance area (AX) and lower reactance at 5 Hz (X5) than the control groups. In inspiratory-expiratory analysis, the asthma group showed increased expiratory R5 and AX and decreased expiratory X5 when compared with the control group. The absolute changes in R5, X5, and AX values between inspiration and expiration were greater in children with asthma than those in controls (0.138 ± 0.195 vs 0.102 ± 0.162, P = 0.014; -0.106 ± 0.200 vs -0.086 ± 0.434, P < 0.001 and 0.460 ± 11.63 vs 0.398 ± 2.88, P = 0.002, respectively). CONCLUSIONS: Inspiratory-expiratory IOS analysis differentiated asthmatic children from control subjects, reflecting airway narrowing on expiration in pediatric asthma. The changes in R5, X5, and AX between inspiration and expiration can be a useful index for diagnosis of asthma in children without assessment of the response to a bronchodilator. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/30536749/Assessment_of_within_breath_impulse_oscillometry_parameters_in_children_with_asthma_ L2 - https://doi.org/10.1002/ppul.24201 DB - PRIME DP - Unbound Medicine ER -