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Correlation of plasma coagulation tests and fibrinogenClauss with rotational thromboelastometry parameters and prediction of bleeding in dogs.
J Vet Intern Med. 2019 Jan; 33(1):132-140.JV

Abstract

BACKGROUND

Correlation of plasma fibrinogen concentration (fibrinogenClauss) with rotational thromboelastometry (ROTEM) parameters has not been investigated in dogs.

OBJECTIVES

To determine the correlation between plasma coagulation tests and fibrinogenClauss with ROTEM parameters and to evaluate their ability to predict bleeding in dogs.

ANIMALS

Ninety-seven dogs with concurrent determination of fibrinogenClauss and fibrin polymerization test (FIBTEM) analysis.

METHODS

Signalment, pretreatment, clinical signs of bleeding, fibrinogenClauss , plasma coagulation test results, hematocrit, platelet count, FIBTEM, extrinsic (EXTEM) and intrinsic (INTEM) activated ROTEM assays were retrieved retrospectively. Correlations between fibrinogenClauss and FIBTEM maximum clot firmness (MCFFIBTEM) and between prothrombin time (PT) or activated partial thromboplastin time (aPTT) and ROTEM parameters were determined. Dogs were further assigned to groups with or without clinical signs of bleeding. The prognostic significance of significantly different parameters to predict bleeding was evaluated.

RESULTS

FibrinogenClauss showed strong correlation with MCFFIBTEM (r = 0.860, n = 97, P < .001). PT showed strong correlation with EXTEM clotting time (CTEXTEM) (r = 0.839, n = 53, P < .001), and aPTT was strongly correlated with INTEM CT (CTINTEM) (r = 0.664, n = 31, P < .001). Platelet count, PT/aPTT, EXTEM clot formation time (CFTEXTEM), MCFEXTEM , EXTEM maximum clot elasticity (MCEEXTEM), and CTINTEM were significantly different between groups. A CTINTEM >149 seconds was 100% sensitive to detect bleeding.

CONCLUSIONS AND CLINICAL IMPORTANCE

The MCFFIBTEM can be used to evaluate the effect of fibrinogen on hemostasis as an alternative to determination of fibrinogenClauss . In addition, CTEXTEM and CTINTEM are strongly correlated with PT and aPTT, respectively.

Authors+Show Affiliations

Department for Small Animals, Critical Care Unit, University of Zurich, Zurich, Switzerland.Department of Clinical Diagnostics and Services, Section of Anesthesiology, University of Zurich, Zurich, Switzerland.Clinic of Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.Department for Small Animals, Critical Care Unit, University of Zurich, Zurich, Switzerland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30537199

Citation

Enk, Nathalie M., et al. "Correlation of Plasma Coagulation Tests and fibrinogenClauss With Rotational Thromboelastometry Parameters and Prediction of Bleeding in Dogs." Journal of Veterinary Internal Medicine, vol. 33, no. 1, 2019, pp. 132-140.
Enk NM, Kutter APN, Kuemmerle-Fraune C, et al. Correlation of plasma coagulation tests and fibrinogenClauss with rotational thromboelastometry parameters and prediction of bleeding in dogs. J Vet Intern Med. 2019;33(1):132-140.
Enk, N. M., Kutter, A. P. N., Kuemmerle-Fraune, C., & Sigrist, N. E. (2019). Correlation of plasma coagulation tests and fibrinogenClauss with rotational thromboelastometry parameters and prediction of bleeding in dogs. Journal of Veterinary Internal Medicine, 33(1), 132-140. https://doi.org/10.1111/jvim.15365
Enk NM, et al. Correlation of Plasma Coagulation Tests and fibrinogenClauss With Rotational Thromboelastometry Parameters and Prediction of Bleeding in Dogs. J Vet Intern Med. 2019;33(1):132-140. PubMed PMID: 30537199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of plasma coagulation tests and fibrinogenClauss with rotational thromboelastometry parameters and prediction of bleeding in dogs. AU - Enk,Nathalie M, AU - Kutter,Annette P N, AU - Kuemmerle-Fraune,Claudia, AU - Sigrist,Nadja E, Y1 - 2018/12/11/ PY - 2018/07/19/received PY - 2018/10/12/accepted PY - 2018/12/12/pubmed PY - 2019/2/8/medline PY - 2018/12/12/entrez KW - FIBTE KW - PT KW - aPTT KW - canine KW - fibrinogen SP - 132 EP - 140 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 33 IS - 1 N2 - BACKGROUND: Correlation of plasma fibrinogen concentration (fibrinogenClauss) with rotational thromboelastometry (ROTEM) parameters has not been investigated in dogs. OBJECTIVES: To determine the correlation between plasma coagulation tests and fibrinogenClauss with ROTEM parameters and to evaluate their ability to predict bleeding in dogs. ANIMALS: Ninety-seven dogs with concurrent determination of fibrinogenClauss and fibrin polymerization test (FIBTEM) analysis. METHODS: Signalment, pretreatment, clinical signs of bleeding, fibrinogenClauss , plasma coagulation test results, hematocrit, platelet count, FIBTEM, extrinsic (EXTEM) and intrinsic (INTEM) activated ROTEM assays were retrieved retrospectively. Correlations between fibrinogenClauss and FIBTEM maximum clot firmness (MCFFIBTEM) and between prothrombin time (PT) or activated partial thromboplastin time (aPTT) and ROTEM parameters were determined. Dogs were further assigned to groups with or without clinical signs of bleeding. The prognostic significance of significantly different parameters to predict bleeding was evaluated. RESULTS: FibrinogenClauss showed strong correlation with MCFFIBTEM (r = 0.860, n = 97, P < .001). PT showed strong correlation with EXTEM clotting time (CTEXTEM) (r = 0.839, n = 53, P < .001), and aPTT was strongly correlated with INTEM CT (CTINTEM) (r = 0.664, n = 31, P < .001). Platelet count, PT/aPTT, EXTEM clot formation time (CFTEXTEM), MCFEXTEM , EXTEM maximum clot elasticity (MCEEXTEM), and CTINTEM were significantly different between groups. A CTINTEM >149 seconds was 100% sensitive to detect bleeding. CONCLUSIONS AND CLINICAL IMPORTANCE: The MCFFIBTEM can be used to evaluate the effect of fibrinogen on hemostasis as an alternative to determination of fibrinogenClauss . In addition, CTEXTEM and CTINTEM are strongly correlated with PT and aPTT, respectively. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/30537199/Correlation_of_plasma_coagulation_tests_and_fibrinogenClauss_with_rotational_thromboelastometry_parameters_and_prediction_of_bleeding_in_dogs_ L2 - https://doi.org/10.1111/jvim.15365 DB - PRIME DP - Unbound Medicine ER -