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Neuroinflammation as a target for glaucoma therapy.
Neural Regen Res. 2019 Mar; 14(3):391-394.NR

Abstract

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. In view of this, therapies aimed at modulating the immune and inflammatory responses may represent a promising approach for limiting the optic nerve damage and the loss of retinal ganglion cells associated with glaucoma.

Authors+Show Affiliations

Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Italy.Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Italy.Visual Neurophysiology and Neurophthalmology Research Unit, IRCCS G.B. Bietti Foundation, Roma, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30539803

Citation

Adornetto, Annagrazia, et al. "Neuroinflammation as a Target for Glaucoma Therapy." Neural Regeneration Research, vol. 14, no. 3, 2019, pp. 391-394.
Adornetto A, Russo R, Parisi V. Neuroinflammation as a target for glaucoma therapy. Neural Regen Res. 2019;14(3):391-394.
Adornetto, A., Russo, R., & Parisi, V. (2019). Neuroinflammation as a target for glaucoma therapy. Neural Regeneration Research, 14(3), 391-394. https://doi.org/10.4103/1673-5374.245465
Adornetto A, Russo R, Parisi V. Neuroinflammation as a Target for Glaucoma Therapy. Neural Regen Res. 2019;14(3):391-394. PubMed PMID: 30539803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroinflammation as a target for glaucoma therapy. AU - Adornetto,Annagrazia, AU - Russo,Rossella, AU - Parisi,Vincenzo, PY - 2018/12/13/entrez PY - 2018/12/13/pubmed PY - 2018/12/13/medline KW - glaucoma KW - immune response KW - inflammasome KW - microglia KW - neurodegeneration KW - neuroinflammation KW - oxidative stress KW - retinal ganglion cells SP - 391 EP - 394 JF - Neural regeneration research JO - Neural Regen Res VL - 14 IS - 3 N2 - The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. In view of this, therapies aimed at modulating the immune and inflammatory responses may represent a promising approach for limiting the optic nerve damage and the loss of retinal ganglion cells associated with glaucoma. SN - 1673-5374 UR - https://www.unboundmedicine.com/medline/citation/30539803/Neuroinflammation_as_a_target_for_glaucoma_therapy_ DB - PRIME DP - Unbound Medicine ER -
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