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Arterial ischemic stroke (AIS) in childhood: clinical report from a single control center.
Childs Nerv Syst 2019; 35(2):283-293CN

Abstract

INTRODUCTION

Stroke is the clinical designation for a rapidly developing loss of brain function due to an interruption in the blood supply to all or part of the brain. It is the third cause of death in adults and one of the top 10 causes in pediatric age. The perinatal period of onset is the second only to adult age group in the incidence of stroke. Arterial ischemic stroke during childhood occurs most frequently in the perinatal period with an incidence of 1 out 2300-5000 live infant births.

MATERIALS AND METHODS

This is a retrospective study that includes 28 patients affected by perinatal arterial ischemic stroke. Family and gestational history, risk factors of perinatal stroke, gender and clinical data of affected children and outcome are reported.

RESULTS

A stroke family history was registered in three unrelated families. Gestational history disclosed cases of threats of abortion, preterm delivery, hyperthermia, gestosis, and placental disorders. In the children, onset of seizures were reported within 3 days of life and diagnosis of stroke was confirmed by brain MRI which disclosed involvement of the middle cerebral artery in all the cases. Hemilateral cerebral palsy, epileptic seizures, and intellectual disability from mild to severe were the most frequent complications.

CONCLUSION

Stroke is still a common and dreadful events in perinatal period as this disorder is often unpredictable and cause of severe neurological impairment.

Authors+Show Affiliations

Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy. ppavone@unict.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30542811

Citation

Portale, Anna, et al. "Arterial Ischemic Stroke (AIS) in Childhood: Clinical Report From a Single Control Center." Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery, vol. 35, no. 2, 2019, pp. 283-293.
Portale A, Fiumara A, Scalora L, et al. Arterial ischemic stroke (AIS) in childhood: clinical report from a single control center. Childs Nerv Syst. 2019;35(2):283-293.
Portale, A., Fiumara, A., Scalora, L., Greco, F., Smilari, P., Venti, V., ... Pavone, P. (2019). Arterial ischemic stroke (AIS) in childhood: clinical report from a single control center. Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery, 35(2), pp. 283-293. doi:10.1007/s00381-018-4017-1.
Portale A, et al. Arterial Ischemic Stroke (AIS) in Childhood: Clinical Report From a Single Control Center. Childs Nerv Syst. 2019;35(2):283-293. PubMed PMID: 30542811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arterial ischemic stroke (AIS) in childhood: clinical report from a single control center. AU - Portale,Anna, AU - Fiumara,Agata, AU - Scalora,Luisa, AU - Greco,Filippo, AU - Smilari,Pierluigi, AU - Venti,Valeria, AU - Pustorino,Elena, AU - Pavone,Piero, Y1 - 2018/12/12/ PY - 2018/10/21/received PY - 2018/11/28/accepted PY - 2018/12/14/pubmed PY - 2018/12/14/medline PY - 2018/12/14/entrez KW - Cerebral palsy KW - Neurological impairment KW - Seizures KW - Stroke SP - 283 EP - 293 JF - Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery JO - Childs Nerv Syst VL - 35 IS - 2 N2 - INTRODUCTION: Stroke is the clinical designation for a rapidly developing loss of brain function due to an interruption in the blood supply to all or part of the brain. It is the third cause of death in adults and one of the top 10 causes in pediatric age. The perinatal period of onset is the second only to adult age group in the incidence of stroke. Arterial ischemic stroke during childhood occurs most frequently in the perinatal period with an incidence of 1 out 2300-5000 live infant births. MATERIALS AND METHODS: This is a retrospective study that includes 28 patients affected by perinatal arterial ischemic stroke. Family and gestational history, risk factors of perinatal stroke, gender and clinical data of affected children and outcome are reported. RESULTS: A stroke family history was registered in three unrelated families. Gestational history disclosed cases of threats of abortion, preterm delivery, hyperthermia, gestosis, and placental disorders. In the children, onset of seizures were reported within 3 days of life and diagnosis of stroke was confirmed by brain MRI which disclosed involvement of the middle cerebral artery in all the cases. Hemilateral cerebral palsy, epileptic seizures, and intellectual disability from mild to severe were the most frequent complications. CONCLUSION: Stroke is still a common and dreadful events in perinatal period as this disorder is often unpredictable and cause of severe neurological impairment. SN - 1433-0350 UR - https://www.unboundmedicine.com/medline/citation/30542811/Arterial_ischemic_stroke_(AIS)_in_childhood:_clinical_report_from_a_single_control_center L2 - https://doi.org/10.1007/s00381-018-4017-1 DB - PRIME DP - Unbound Medicine ER -