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Versatile spider venom peptides and their medical and agricultural applications.
Toxicon. 2019 Feb; 158:109-126.T

Abstract

Spiders have been evolving complex and diverse repertoires of peptides in their venoms with vast pharmacological activities for more than 300 million years. Spiders use their venoms for prey capture and defense, hence they contain peptides that target both prey (mainly arthropods) and predators (other arthropods or vertebrates). This includes peptides that potently and selectively modulate a range of targets such as ion channels, receptors and signaling pathways involved in physiological processes. The contribution of these targets in particular disease pathophysiologies makes spider venoms a valuable source of peptides with potential therapeutic use. In addition, peptides with insecticidal activities, used for prey capture, can be exploited for the development of novel bioinsecticides for agricultural use. Although we have already reviewed potential applications of spider venom peptides as therapeutics (in 2010) and as bioinsecticides (in 2012), a considerable number of research articles on both topics have been published since, warranting an updated review. Here we explore the most recent research on the use of spider venom peptides for both medical and agricultural applications.

Authors+Show Affiliations

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: n.saez@uq.edu.au.Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: v.herzig@uq.edu.au.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30543821

Citation

Saez, Natalie J., and Volker Herzig. "Versatile Spider Venom Peptides and Their Medical and Agricultural Applications." Toxicon : Official Journal of the International Society On Toxinology, vol. 158, 2019, pp. 109-126.
Saez NJ, Herzig V. Versatile spider venom peptides and their medical and agricultural applications. Toxicon. 2019;158:109-126.
Saez, N. J., & Herzig, V. (2019). Versatile spider venom peptides and their medical and agricultural applications. Toxicon : Official Journal of the International Society On Toxinology, 158, 109-126. https://doi.org/10.1016/j.toxicon.2018.11.298
Saez NJ, Herzig V. Versatile Spider Venom Peptides and Their Medical and Agricultural Applications. Toxicon. 2019;158:109-126. PubMed PMID: 30543821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Versatile spider venom peptides and their medical and agricultural applications. AU - Saez,Natalie J, AU - Herzig,Volker, Y1 - 2018/12/11/ PY - 2018/05/02/received PY - 2018/11/12/revised PY - 2018/11/14/accepted PY - 2018/12/14/pubmed PY - 2019/6/6/medline PY - 2018/12/14/entrez KW - Arachnid KW - Arthropod KW - Bioinsecticide KW - Insecticidal spider venom peptide KW - Spider KW - Therapeutics KW - Toxins KW - Venom-based drug discovery SP - 109 EP - 126 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 158 N2 - Spiders have been evolving complex and diverse repertoires of peptides in their venoms with vast pharmacological activities for more than 300 million years. Spiders use their venoms for prey capture and defense, hence they contain peptides that target both prey (mainly arthropods) and predators (other arthropods or vertebrates). This includes peptides that potently and selectively modulate a range of targets such as ion channels, receptors and signaling pathways involved in physiological processes. The contribution of these targets in particular disease pathophysiologies makes spider venoms a valuable source of peptides with potential therapeutic use. In addition, peptides with insecticidal activities, used for prey capture, can be exploited for the development of novel bioinsecticides for agricultural use. Although we have already reviewed potential applications of spider venom peptides as therapeutics (in 2010) and as bioinsecticides (in 2012), a considerable number of research articles on both topics have been published since, warranting an updated review. Here we explore the most recent research on the use of spider venom peptides for both medical and agricultural applications. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/30543821/Versatile_spider_venom_peptides_and_their_medical_and_agricultural_applications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(18)31019-5 DB - PRIME DP - Unbound Medicine ER -
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