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Clinical features related to statin-associated muscle symptoms.
Muscle Nerve. 2019 05; 59(5):537-543.MN

Abstract

INTRODUCTION

Statins reduce cardiovascular disease risk and are generally well tolerated, yet up to 0.5% of statin-treated patients develop incapacitating muscle symptoms including rhabdomyolysis. Our objective was to identify clinical factors related to statin-associated muscle symptoms (SAMS).

METHODS

Clinical and laboratory characteristics were evaluated in 748 statin-treated Caucasians (634 with SAMS and 114 statin-tolerant controls). Information was collected on statin type, concomitant drug therapies, muscle symptom history, comorbidities, and family history. Logistic regression was used to identify associations.

RESULTS

Individuals with SAMS were 3.6 times (odds ratio [OR] 3.60, 95% confidence interval [CI] 2.08-6.22) more likely than statin-tolerant controls to have a family history of heart disease. Additional associations included obesity (OR 3.08, 95% CI 1.18, 8.05), hypertension (OR 2.24, 95% CI 1.33, 3.77), smoking (OR 2.08, 95% CI 1.16, 3.74), and statin type.

DISCUSSION

Careful medical monitoring of statin-treated patients with the associated coexisting conditions may ultimately reduce muscle symptoms and lead to improved compliance. Muscle Nerve 59:537-537, 2019.

Authors+Show Affiliations

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, 270 Farber Hall, Buffalo, New York, 14214-8001, USA.Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.Department of Biostatistics, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA.Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA. Kaleida Health Laboratories, Buffalo, New York, USA.Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.Department of Medicine, Division of Rheumatology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.Department of Medicine, The Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA. Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA. Department of Pathology & Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

30549046

Citation

Ochs-Balcom, Heather M., et al. "Clinical Features Related to Statin-associated Muscle Symptoms." Muscle & Nerve, vol. 59, no. 5, 2019, pp. 537-543.
Ochs-Balcom HM, Nguyen LM, Ma C, et al. Clinical features related to statin-associated muscle symptoms. Muscle Nerve. 2019;59(5):537-543.
Ochs-Balcom, H. M., Nguyen, L. M., Ma, C., Isackson, P. J., Luzum, J. A., Kitzmiller, J. P., Tarnopolsky, M., Weisman, M., Christopher-Stine, L., Peltier, W., Wortmann, R. L., & Vladutiu, G. D. (2019). Clinical features related to statin-associated muscle symptoms. Muscle & Nerve, 59(5), 537-543. https://doi.org/10.1002/mus.26397
Ochs-Balcom HM, et al. Clinical Features Related to Statin-associated Muscle Symptoms. Muscle Nerve. 2019;59(5):537-543. PubMed PMID: 30549046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features related to statin-associated muscle symptoms. AU - Ochs-Balcom,Heather M, AU - Nguyen,Ly Minh, AU - Ma,Changxing, AU - Isackson,Paul J, AU - Luzum,Jasmine A, AU - Kitzmiller,Joseph P, AU - Tarnopolsky,Mark, AU - Weisman,Michael, AU - Christopher-Stine,Lisa, AU - Peltier,Wendy, AU - Wortmann,Robert L, AU - Vladutiu,Georgirene D, Y1 - 2019/01/11/ PY - 2018/04/10/received PY - 2018/12/05/revised PY - 2018/12/10/accepted PY - 2020/05/01/pmc-release PY - 2018/12/15/pubmed PY - 2019/10/23/medline PY - 2018/12/15/entrez KW - muscle disease KW - rhabdomyolysis KW - risk factors KW - statin-associated muscle symptoms KW - statins SP - 537 EP - 543 JF - Muscle & nerve JO - Muscle Nerve VL - 59 IS - 5 N2 - INTRODUCTION: Statins reduce cardiovascular disease risk and are generally well tolerated, yet up to 0.5% of statin-treated patients develop incapacitating muscle symptoms including rhabdomyolysis. Our objective was to identify clinical factors related to statin-associated muscle symptoms (SAMS). METHODS: Clinical and laboratory characteristics were evaluated in 748 statin-treated Caucasians (634 with SAMS and 114 statin-tolerant controls). Information was collected on statin type, concomitant drug therapies, muscle symptom history, comorbidities, and family history. Logistic regression was used to identify associations. RESULTS: Individuals with SAMS were 3.6 times (odds ratio [OR] 3.60, 95% confidence interval [CI] 2.08-6.22) more likely than statin-tolerant controls to have a family history of heart disease. Additional associations included obesity (OR 3.08, 95% CI 1.18, 8.05), hypertension (OR 2.24, 95% CI 1.33, 3.77), smoking (OR 2.08, 95% CI 1.16, 3.74), and statin type. DISCUSSION: Careful medical monitoring of statin-treated patients with the associated coexisting conditions may ultimately reduce muscle symptoms and lead to improved compliance. Muscle Nerve 59:537-537, 2019. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/30549046/Clinical_features_related_to_statin_associated_muscle_symptoms_ L2 - https://doi.org/10.1002/mus.26397 DB - PRIME DP - Unbound Medicine ER -