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Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty.
PLoS One. 2018; 13(12):e0205810.Plos

Abstract

OBJECTIVE

To compare the serum inhibin B, anti-Müllerian hormone (AMH) and leptin concentrations in girls with idiopathic central precocious puberty (CPP) to their concomitant characteristics and evaluate the capacity of each of these hormones to predict the age at first menstruation in those who were untreated and who completed their puberty.

METHODS

This single-center study included 94 girls selected from a cohort of 493 girls seen between 1981 and 2012 and diagnosed with idiopathic CPP for whom a remaining serum sample collected at the initial evaluation was available. Of these 25 were untreated and completed their puberty.

RESULTS- CORRELATIONS AT INITIAL EVALUATION

In the whole cohort the inhibin B concentration displayed significant positive correlations with the age at the onset of puberty and at initial evaluation; bone age; breast Tanner stage; serum basal estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and AMH concentrations, LH peak and LH/FSH peak ratio. The AMH concentration displayed a significant positive correlation with serum estradiol and a negative correlation with basal FSH concentration. The leptin concentration displayed significant positive correlations with the age at initial evaluation, bone age, and body mass index and a negative correlation with the FSH peak.

RESULTS- PREDICTION OF AGE AT FIRST MENSTRUATION

In 25 untreated girls, the inhibin B concentration was negatively correlated with the age at first menstruation (r = -0.61, p = 0.001) and the time between the onset of puberty and first menstruation (r = -0.59, p = 0.002). Inhibin B concentrations <30 pg/mL were associated with a time between the onset of puberty and first menstruation ≥3 years in 14/15 patients with a sensitivity of 0.67 and a specificity of 0.75. The age at first menstruation was estimated using a formula: min (11.15-0.510 LH/FSH peak ratio, 11.57-0.025 inhibin B)available at: http://www.kamick.org/lemaire/med/girls-cpp18.html.

CONCLUSION

We established formulas based on the serum inhibin B concentrations and LH/FSH peak ratio at the initial evaluation, alone or in combination, to predict the age at first menstruation in girls with CPP. These formulas can assist with determining the indications for treatment in CPP.

Authors+Show Affiliations

Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, Paris, France.Univ. Grenoble Alpes, CNRS, Grenoble INP, G-SCOP, Grenoble, France.Faculté de médecine Paris Sud, Université Paris Saclay and Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Sud, CHU Bicêtre, Service de Génétique Moléculaire, Pharmacogénétique, Hormonologie, Le Kremlin-Bicêtre, France.Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, Paris, France.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

30550563

Citation

Tencer, Jérémie, et al. "Serum Inhibin B Concentration as a Predictor of Age at First Menstruation in Girls With Idiopathic Central Precocious Puberty." PloS One, vol. 13, no. 12, 2018, pp. e0205810.
Tencer J, Lemaire P, Brailly-Tabard S, et al. Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty. PLoS ONE. 2018;13(12):e0205810.
Tencer, J., Lemaire, P., Brailly-Tabard, S., & Brauner, R. (2018). Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty. PloS One, 13(12), e0205810. https://doi.org/10.1371/journal.pone.0205810
Tencer J, et al. Serum Inhibin B Concentration as a Predictor of Age at First Menstruation in Girls With Idiopathic Central Precocious Puberty. PLoS ONE. 2018;13(12):e0205810. PubMed PMID: 30550563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty. AU - Tencer,Jérémie, AU - Lemaire,Pierre, AU - Brailly-Tabard,Sylvie, AU - Brauner,Raja, Y1 - 2018/12/14/ PY - 2018/01/09/received PY - 2018/10/02/accepted PY - 2018/12/15/entrez PY - 2018/12/15/pubmed PY - 2019/4/25/medline SP - e0205810 EP - e0205810 JF - PloS one JO - PLoS ONE VL - 13 IS - 12 N2 - OBJECTIVE: To compare the serum inhibin B, anti-Müllerian hormone (AMH) and leptin concentrations in girls with idiopathic central precocious puberty (CPP) to their concomitant characteristics and evaluate the capacity of each of these hormones to predict the age at first menstruation in those who were untreated and who completed their puberty. METHODS: This single-center study included 94 girls selected from a cohort of 493 girls seen between 1981 and 2012 and diagnosed with idiopathic CPP for whom a remaining serum sample collected at the initial evaluation was available. Of these 25 were untreated and completed their puberty. RESULTS- CORRELATIONS AT INITIAL EVALUATION: In the whole cohort the inhibin B concentration displayed significant positive correlations with the age at the onset of puberty and at initial evaluation; bone age; breast Tanner stage; serum basal estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and AMH concentrations, LH peak and LH/FSH peak ratio. The AMH concentration displayed a significant positive correlation with serum estradiol and a negative correlation with basal FSH concentration. The leptin concentration displayed significant positive correlations with the age at initial evaluation, bone age, and body mass index and a negative correlation with the FSH peak. RESULTS- PREDICTION OF AGE AT FIRST MENSTRUATION: In 25 untreated girls, the inhibin B concentration was negatively correlated with the age at first menstruation (r = -0.61, p = 0.001) and the time between the onset of puberty and first menstruation (r = -0.59, p = 0.002). Inhibin B concentrations <30 pg/mL were associated with a time between the onset of puberty and first menstruation ≥3 years in 14/15 patients with a sensitivity of 0.67 and a specificity of 0.75. The age at first menstruation was estimated using a formula: min (11.15-0.510 LH/FSH peak ratio, 11.57-0.025 inhibin B)available at: http://www.kamick.org/lemaire/med/girls-cpp18.html. CONCLUSION: We established formulas based on the serum inhibin B concentrations and LH/FSH peak ratio at the initial evaluation, alone or in combination, to predict the age at first menstruation in girls with CPP. These formulas can assist with determining the indications for treatment in CPP. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/30550563/Serum_inhibin_B_concentration_as_a_predictor_of_age_at_first_menstruation_in_girls_with_idiopathic_central_precocious_puberty_ L2 - http://dx.plos.org/10.1371/journal.pone.0205810 DB - PRIME DP - Unbound Medicine ER -