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Spectral-domain optical coherence tomography foveal morphology as a prognostic factor for vision performance in congenital aniridia.
Eur J Ophthalmol. 2020 Jan; 30(1):58-65.EJ

Abstract

BACKGROUND

Patients with congenital aniridia usually have some degree of foveal hypoplasia, thus representing a limiting factor in the final visual acuity achieved by these patients. The purpose of this study was to analyze whether the foveal morphology assessed by spectral-domain optical coherence tomography may serve as a prognostic indicator for best-corrected visual acuity in congenital aniridia patients.

METHODS

Observational two-center study performed between January 2012 and March 2017 in the pediatric ophthalmology department at Vissum Alicante and Vissum Madrid, Spain. A total of 31 eyes from 19 patients with congenital aniridia were included. After a complete ophthalmological examination, a high-resolution spectral-domain optical coherence tomography with a three-dimensional scan program macular protocol was used. A morphological grading system of foveal hypoplasia was used varying from grade 1 in which there is a presence of a shallow foveal pit, extrusion of inner retinal layers, outer nuclear layer widening, and a presence of outer segment lengthening to grade 4 in which none of these processes occur.

RESULTS

No correlation between central, mid-peripheral, and peripheral macular thickness and logMAR best-corrected visual acuity was found. The presence of outer segment lengthening was associated with better best-corrected visual acuity with a median best-corrected visual acuity, 0.30 logMAR, whereas the absence of this morphologic feature was associated with poorer VA with a median best-corrected visual acuity of 0.61 logMAR (p < 0.001).

CONCLUSION

Foveal hypoplasia morphology can predict the best-corrected visual acuity. Specifically, the morphologic optical coherence tomography feature that is related to a better best-corrected visual acuity in congenital aniridia patients is the presence of outer segment lengthening.

Authors+Show Affiliations

VISSUM Alicante, Alicante, Spain. VISSUM Madrid, Madrid, Spain.VISSUM Alicante, Alicante, Spain.VISSUM Madrid, Madrid, Spain.VISSUM Madrid, Madrid, Spain.VISSUM Alicante, Alicante, Spain. Miguel Hernández University, Elche, Spain.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

30556423

Citation

Casas-Llera, Pilar, et al. "Spectral-domain Optical Coherence Tomography Foveal Morphology as a Prognostic Factor for Vision Performance in Congenital Aniridia." European Journal of Ophthalmology, vol. 30, no. 1, 2020, pp. 58-65.
Casas-Llera P, Siverio A, Esquivel G, et al. Spectral-domain optical coherence tomography foveal morphology as a prognostic factor for vision performance in congenital aniridia. Eur J Ophthalmol. 2020;30(1):58-65.
Casas-Llera, P., Siverio, A., Esquivel, G., Bautista, C., & Alió, J. L. (2020). Spectral-domain optical coherence tomography foveal morphology as a prognostic factor for vision performance in congenital aniridia. European Journal of Ophthalmology, 30(1), 58-65. https://doi.org/10.1177/1120672118818352
Casas-Llera P, et al. Spectral-domain Optical Coherence Tomography Foveal Morphology as a Prognostic Factor for Vision Performance in Congenital Aniridia. Eur J Ophthalmol. 2020;30(1):58-65. PubMed PMID: 30556423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectral-domain optical coherence tomography foveal morphology as a prognostic factor for vision performance in congenital aniridia. AU - Casas-Llera,Pilar, AU - Siverio,Ana, AU - Esquivel,Gemma, AU - Bautista,Cristina, AU - Alió,Jorge L, Y1 - 2018/12/17/ PY - 2018/12/18/pubmed PY - 2020/2/15/medline PY - 2018/12/18/entrez KW - Congenital aniridia KW - foveal hypoplasia KW - spectral-domain optical coherence tomography SP - 58 EP - 65 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 30 IS - 1 N2 - BACKGROUND: Patients with congenital aniridia usually have some degree of foveal hypoplasia, thus representing a limiting factor in the final visual acuity achieved by these patients. The purpose of this study was to analyze whether the foveal morphology assessed by spectral-domain optical coherence tomography may serve as a prognostic indicator for best-corrected visual acuity in congenital aniridia patients. METHODS: Observational two-center study performed between January 2012 and March 2017 in the pediatric ophthalmology department at Vissum Alicante and Vissum Madrid, Spain. A total of 31 eyes from 19 patients with congenital aniridia were included. After a complete ophthalmological examination, a high-resolution spectral-domain optical coherence tomography with a three-dimensional scan program macular protocol was used. A morphological grading system of foveal hypoplasia was used varying from grade 1 in which there is a presence of a shallow foveal pit, extrusion of inner retinal layers, outer nuclear layer widening, and a presence of outer segment lengthening to grade 4 in which none of these processes occur. RESULTS: No correlation between central, mid-peripheral, and peripheral macular thickness and logMAR best-corrected visual acuity was found. The presence of outer segment lengthening was associated with better best-corrected visual acuity with a median best-corrected visual acuity, 0.30 logMAR, whereas the absence of this morphologic feature was associated with poorer VA with a median best-corrected visual acuity of 0.61 logMAR (p < 0.001). CONCLUSION: Foveal hypoplasia morphology can predict the best-corrected visual acuity. Specifically, the morphologic optical coherence tomography feature that is related to a better best-corrected visual acuity in congenital aniridia patients is the presence of outer segment lengthening. SN - 1724-6016 UR - https://www.unboundmedicine.com/medline/citation/30556423/Spectral_domain_optical_coherence_tomography_foveal_morphology_as_a_prognostic_factor_for_vision_performance_in_congenital_aniridia_ L2 - https://journals.sagepub.com/doi/10.1177/1120672118818352?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -