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Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease.
J Am Acad Dermatol. 2019 Mar; 80(3):749-755.JA

Abstract

BACKGROUND

Clear cell acanthoma (CCA) of the nipple/areola has been reported. The CCA-like histology more likely represents a feature of eczematous dermatitis of the nipple/areola.

OBJECTIVE

We reviewed cases of CCA-like lesions of the nipple/areola and compared them with classic CCA to clarify their relationship.

METHODS

The clinicopathological features of 12 cases of CCA-like lesions of the nipple/areola were compared with classic CCA. The literature on this condition was reviewed, and the results of various treatments were analyzed.

RESULTS

CCA-like lesions of the nipple/areola were clinically different from those of classic CCA. Although they shared the glycogen-rich clear epidermal cells with neutrophilic exocytosis, dermal eosinophils appeared to be a distinctive feature. The anatomic site and association with atopic dermatitis suggested that CCA-like lesions of nipple/areola might represent a manifestation of atopic eczema involving nipple/areola. Topical steroids could be effective.

LIMITATIONS

This was a retrospective study with limited cases.

CONCLUSIONS

Although CCA-like lesions of the nipple/areola shared histopathological features with classic CCA, their clinical changes were consistent with dermatitis. We propose to name this condition CCA-like eczematous dermatitis of the nipple/areola.

Authors+Show Affiliations

Department of Dermatology, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan.Department of Dermatology, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan.Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address: ttkuo@cgmh.org.tw.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30558902

Citation

Kuo, Kang-Ling, et al. "Clear Cell Acanthoma (CCA)-like Lesions of the Nipple/areola: a Clinicopathological Study of 12 Cases Supporting a Nonneoplastic Eczematous Disease." Journal of the American Academy of Dermatology, vol. 80, no. 3, 2019, pp. 749-755.
Kuo KL, Lo CS, Lee LY, et al. Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. J Am Acad Dermatol. 2019;80(3):749-755.
Kuo, K. L., Lo, C. S., Lee, L. Y., Yang, C. H., & Kuo, T. T. (2019). Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. Journal of the American Academy of Dermatology, 80(3), 749-755. https://doi.org/10.1016/j.jaad.2016.07.032
Kuo KL, et al. Clear Cell Acanthoma (CCA)-like Lesions of the Nipple/areola: a Clinicopathological Study of 12 Cases Supporting a Nonneoplastic Eczematous Disease. J Am Acad Dermatol. 2019;80(3):749-755. PubMed PMID: 30558902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. AU - Kuo,Kang-Ling, AU - Lo,Chi-Shou, AU - Lee,Li-Yu, AU - Yang,Chih-Hsun, AU - Kuo,Tseng-Tong, Y1 - 2018/12/14/ PY - 2016/03/23/received PY - 2016/07/08/revised PY - 2016/07/14/accepted PY - 2018/12/19/pubmed PY - 2019/3/26/medline PY - 2018/12/19/entrez KW - areola KW - breast KW - clear cell acanthoma KW - dermoscope KW - eczema KW - nipple SP - 749 EP - 755 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 80 IS - 3 N2 - BACKGROUND: Clear cell acanthoma (CCA) of the nipple/areola has been reported. The CCA-like histology more likely represents a feature of eczematous dermatitis of the nipple/areola. OBJECTIVE: We reviewed cases of CCA-like lesions of the nipple/areola and compared them with classic CCA to clarify their relationship. METHODS: The clinicopathological features of 12 cases of CCA-like lesions of the nipple/areola were compared with classic CCA. The literature on this condition was reviewed, and the results of various treatments were analyzed. RESULTS: CCA-like lesions of the nipple/areola were clinically different from those of classic CCA. Although they shared the glycogen-rich clear epidermal cells with neutrophilic exocytosis, dermal eosinophils appeared to be a distinctive feature. The anatomic site and association with atopic dermatitis suggested that CCA-like lesions of nipple/areola might represent a manifestation of atopic eczema involving nipple/areola. Topical steroids could be effective. LIMITATIONS: This was a retrospective study with limited cases. CONCLUSIONS: Although CCA-like lesions of the nipple/areola shared histopathological features with classic CCA, their clinical changes were consistent with dermatitis. We propose to name this condition CCA-like eczematous dermatitis of the nipple/areola. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/30558902/Clear_cell_acanthoma_(CCA)-like_lesions_of_the_nipple/areola:_A_clinicopathological_study_of_12_cases_supporting_a_nonneoplastic_eczematous_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(16)30551-5 DB - PRIME DP - Unbound Medicine ER -