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Effects of AT-RvD1 on paraquat-induced acute renal injury in mice.
Int Immunopharmacol. 2019 Feb; 67:231-238.II

Abstract

OBJECTIVE

To investigate the effects of aspirin-triggered resolvin D1 (AT-RvD1) on paraquat-induced acute renal injury (ARI) in mice.

METHODS

The ARI mouse model was established by administering 28 mg/kg paraquat to C57BL/6J mice by intraperitoneal injection. The mice received 10 or 100 ng AT-RvD1 by intravenous injection in the tail vein 2 h after toxication. The mice were euthanized 6, 24, or 72 h post-paraquat injection to collect blood and renal tissues. The samples were used to evaluate the pathological changes, renal function, inflammation and oxidative stress in the renal tissues.

RESULTS

Compared with those of the PQ group, AT-RvD1 administration mitigated the pathological changes and improved renal function, activated Nrf2 and upregulated the expression of its downstream antioxidant genes (NQO1, HO-1, SOD1 and GPx1), and decreased the MDA and protein carbonyls content in renal tissues. Treatment also reduced the expression of P-selectin in renal tissues, the percentage of Ly-6G+ CD41+ cells in the peripheral blood and infiltration of neutrophils in renal tissues. Furthermore, AT-RvD1 inhibited the activation of NF-κB and reduced IL-1β and TNF-α serum levels.

CONCLUSION

The administration of AT-RvD1 can effectively suppress paraquat-induced oxidative stress injury and the inflammatory reaction, and alleviate paraquat-induced ARI.

Authors+Show Affiliations

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: zhaom@sj-hospital.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30562684

Citation

Hu, Xiao, et al. "Effects of AT-RvD1 On Paraquat-induced Acute Renal Injury in Mice." International Immunopharmacology, vol. 67, 2019, pp. 231-238.
Hu X, Liang Y, Zhao H, et al. Effects of AT-RvD1 on paraquat-induced acute renal injury in mice. Int Immunopharmacol. 2019;67:231-238.
Hu, X., Liang, Y., Zhao, H., & Zhao, M. (2019). Effects of AT-RvD1 on paraquat-induced acute renal injury in mice. International Immunopharmacology, 67, 231-238. https://doi.org/10.1016/j.intimp.2018.12.029
Hu X, et al. Effects of AT-RvD1 On Paraquat-induced Acute Renal Injury in Mice. Int Immunopharmacol. 2019;67:231-238. PubMed PMID: 30562684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of AT-RvD1 on paraquat-induced acute renal injury in mice. AU - Hu,Xiao, AU - Liang,Yuanyuan, AU - Zhao,Hongyu, AU - Zhao,Min, Y1 - 2018/12/15/ PY - 2018/11/20/received PY - 2018/12/09/revised PY - 2018/12/11/accepted PY - 2018/12/19/pubmed PY - 2019/5/10/medline PY - 2018/12/19/entrez KW - AT-RvD1 KW - Acute renal injury KW - Paraquat SP - 231 EP - 238 JF - International immunopharmacology JO - Int Immunopharmacol VL - 67 N2 - OBJECTIVE: To investigate the effects of aspirin-triggered resolvin D1 (AT-RvD1) on paraquat-induced acute renal injury (ARI) in mice. METHODS: The ARI mouse model was established by administering 28 mg/kg paraquat to C57BL/6J mice by intraperitoneal injection. The mice received 10 or 100 ng AT-RvD1 by intravenous injection in the tail vein 2 h after toxication. The mice were euthanized 6, 24, or 72 h post-paraquat injection to collect blood and renal tissues. The samples were used to evaluate the pathological changes, renal function, inflammation and oxidative stress in the renal tissues. RESULTS: Compared with those of the PQ group, AT-RvD1 administration mitigated the pathological changes and improved renal function, activated Nrf2 and upregulated the expression of its downstream antioxidant genes (NQO1, HO-1, SOD1 and GPx1), and decreased the MDA and protein carbonyls content in renal tissues. Treatment also reduced the expression of P-selectin in renal tissues, the percentage of Ly-6G+ CD41+ cells in the peripheral blood and infiltration of neutrophils in renal tissues. Furthermore, AT-RvD1 inhibited the activation of NF-κB and reduced IL-1β and TNF-α serum levels. CONCLUSION: The administration of AT-RvD1 can effectively suppress paraquat-induced oxidative stress injury and the inflammatory reaction, and alleviate paraquat-induced ARI. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/30562684/Effects_of_AT_RvD1_on_paraquat_induced_acute_renal_injury_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(18)31172-X DB - PRIME DP - Unbound Medicine ER -