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The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome.
Biol Trace Elem Res. 2019 Sep; 191(1):54-60.BT

Abstract

Synergistic approach of magnesium and vitamin E may benefit clinical symptoms of patients with polycystic ovary syndrome (PCOS) through improving their metabolic profiles and reducing oxidative stress and inflammation. This study was designed to determine the effects of magnesium and vitamin E co-supplementation on hormonal status and biomarkers of inflammation and oxidative stress in women with PCOS. This randomized, double-blind, placebo-controlled trial was conducted among 60 women with PCOS, aged 18-40 years old. Participants were randomly divided into two groups to take 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention to quantify related variables. Magnesium and vitamin E co-supplementation resulted in a significant reduction in hirsutism (β - 0.37; 95% CI, - 0.70, - 0.05; P = 0.02) and serum high-sensitivity C-reactive protein (hs-CRP) (β - 0.67 mg/L; 95% CI, - 1.20, - 0.14; P = 0.01), and a significant increase in plasma nitric oxide (NO) (β 3.40 μmol/L; 95% CI, 1.46, 5.35; P = 0.001) and total antioxidant capacity (TAC) levels (β 66.32 mmol/L; 95% CI, 43.80, 88.84; P < 0.001). Overall, magnesium and vitamin E co-supplementation for 12 weeks may benefit women with PCOS on hirsutism, serum hs-CRP, plasma NO, and TAC levels. Clinical trial registration number http://www.irct.ir : IRCT2017082733941N8.

Authors+Show Affiliations

Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran. asemi_r@yahoo.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30565017

Citation

Shokrpour, Maryam, and Zatollah Asemi. "The Effects of Magnesium and Vitamin E Co-Supplementation On Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome." Biological Trace Element Research, vol. 191, no. 1, 2019, pp. 54-60.
Shokrpour M, Asemi Z. The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome. Biol Trace Elem Res. 2019;191(1):54-60.
Shokrpour, M., & Asemi, Z. (2019). The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome. Biological Trace Element Research, 191(1), 54-60. https://doi.org/10.1007/s12011-018-1602-9
Shokrpour M, Asemi Z. The Effects of Magnesium and Vitamin E Co-Supplementation On Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome. Biol Trace Elem Res. 2019;191(1):54-60. PubMed PMID: 30565017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome. AU - Shokrpour,Maryam, AU - Asemi,Zatollah, Y1 - 2018/12/18/ PY - 2018/08/12/received PY - 2018/12/03/accepted PY - 2018/12/20/pubmed PY - 2019/12/25/medline PY - 2018/12/20/entrez KW - Hormonal status KW - Inflammation KW - Oxidative damage KW - Supplementation SP - 54 EP - 60 JF - Biological trace element research JO - Biol Trace Elem Res VL - 191 IS - 1 N2 - Synergistic approach of magnesium and vitamin E may benefit clinical symptoms of patients with polycystic ovary syndrome (PCOS) through improving their metabolic profiles and reducing oxidative stress and inflammation. This study was designed to determine the effects of magnesium and vitamin E co-supplementation on hormonal status and biomarkers of inflammation and oxidative stress in women with PCOS. This randomized, double-blind, placebo-controlled trial was conducted among 60 women with PCOS, aged 18-40 years old. Participants were randomly divided into two groups to take 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention to quantify related variables. Magnesium and vitamin E co-supplementation resulted in a significant reduction in hirsutism (β - 0.37; 95% CI, - 0.70, - 0.05; P = 0.02) and serum high-sensitivity C-reactive protein (hs-CRP) (β - 0.67 mg/L; 95% CI, - 1.20, - 0.14; P = 0.01), and a significant increase in plasma nitric oxide (NO) (β 3.40 μmol/L; 95% CI, 1.46, 5.35; P = 0.001) and total antioxidant capacity (TAC) levels (β 66.32 mmol/L; 95% CI, 43.80, 88.84; P < 0.001). Overall, magnesium and vitamin E co-supplementation for 12 weeks may benefit women with PCOS on hirsutism, serum hs-CRP, plasma NO, and TAC levels. Clinical trial registration number http://www.irct.ir : IRCT2017082733941N8. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/30565017/The_Effects_of_Magnesium_and_Vitamin_E_Co_Supplementation_on_Hormonal_Status_and_Biomarkers_of_Inflammation_and_Oxidative_Stress_in_Women_with_Polycystic_Ovary_Syndrome_ L2 - https://dx.doi.org/10.1007/s12011-018-1602-9 DB - PRIME DP - Unbound Medicine ER -