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Investigation of the prolonged hypoglycemic effect of human proinsulin in diabetes mellitus.
Horm Metab Res Suppl. 1988; 18:12-5.HM

Abstract

Human proinsulin possesses a clear hypoglycemic effect, the extent and kinetics of which were investigated in 8 insulin dependent diabetics. In addition, to adequate therapy with a controlled-release insulin, each patient received i.v. injections of insulin (e U) and proinsulin (9 U) on separate test days. After 9 U of proinsulin, the blood glucose decrease was delayed in comparison to 3 U of insulin. However, it reached identical maximum blood glucose decrease values. The elimination kinetics of proinsulin are delayed compared to insulin. There is a linear relation between the time and the reciprocal value of the measured insulin immuno-reactivity. The hypoglycemic effect of proinsulin which is protracted for hours corresponds to that of an extreme controlled-release insulin. Under certain conditions, proinsulin might therefore prove effective in the long-term treatment of the insulin-dependent diabetes mellitus.

Authors+Show Affiliations

III. Med. Klinik und Poliklinik, Universität Giessen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3056806

Citation

Laube, H, et al. "Investigation of the Prolonged Hypoglycemic Effect of Human Proinsulin in Diabetes Mellitus." Hormone and Metabolic Research. Supplement Series, vol. 18, 1988, pp. 12-5.
Laube H, Pinter W, Federlin K. Investigation of the prolonged hypoglycemic effect of human proinsulin in diabetes mellitus. Horm Metab Res Suppl. 1988;18:12-5.
Laube, H., Pinter, W., & Federlin, K. (1988). Investigation of the prolonged hypoglycemic effect of human proinsulin in diabetes mellitus. Hormone and Metabolic Research. Supplement Series, 18, 12-5.
Laube H, Pinter W, Federlin K. Investigation of the Prolonged Hypoglycemic Effect of Human Proinsulin in Diabetes Mellitus. Horm Metab Res Suppl. 1988;18:12-5. PubMed PMID: 3056806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of the prolonged hypoglycemic effect of human proinsulin in diabetes mellitus. AU - Laube,H, AU - Pinter,W, AU - Federlin,K, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 12 EP - 5 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl VL - 18 N2 - Human proinsulin possesses a clear hypoglycemic effect, the extent and kinetics of which were investigated in 8 insulin dependent diabetics. In addition, to adequate therapy with a controlled-release insulin, each patient received i.v. injections of insulin (e U) and proinsulin (9 U) on separate test days. After 9 U of proinsulin, the blood glucose decrease was delayed in comparison to 3 U of insulin. However, it reached identical maximum blood glucose decrease values. The elimination kinetics of proinsulin are delayed compared to insulin. There is a linear relation between the time and the reciprocal value of the measured insulin immuno-reactivity. The hypoglycemic effect of proinsulin which is protracted for hours corresponds to that of an extreme controlled-release insulin. Under certain conditions, proinsulin might therefore prove effective in the long-term treatment of the insulin-dependent diabetes mellitus. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/3056806/Investigation_of_the_prolonged_hypoglycemic_effect_of_human_proinsulin_in_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -
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