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Association between sunlight exposure and risk of age-related macular degeneration: a meta-analysis.
BMC Ophthalmol 2018; 18(1):331BO

Abstract

BACKGROUND

A substantial number of epidemiological studies have investigated the possible associations between sunlight exposure and Age-related Macular Degeneration (AMD), but the results from studies are inconsistent. The aim of this meta-analysis was to evaluate the association between sunlight exposure and the risk of AMD.

METHODS

Relevant studies were searched using databases including PubMed, EMBASE, and Web of Science database. Two authors independently extracted data and assessed study quality. The random-effects model was used to calculate the pooled covariates-adjusted odds ratio (OR). Subgroup analyses based on study design, stage of AMD, method of exposure assessment, and study latitude were carried out. The heterogeneity across the studies was tested, as was publication bias.

RESULTS

Fourteen eligible studies including 43,934 individuals based on the inclusion criteria were analyzed. The pooled OR for sunlight exposure and AMD was 1.10 (95% CI = 0.98-1.23). In addition, similar insignificant results were observed in further subgroup analyses based on stage of AMD, method of exposure assessment, and study latitude. Sun-avoidance behavior did not decrease the risk of AMD (OR = 1.12, 95% CI = 0.76-1.67). Moderate heterogeneity was observed in most of analyses.

CONCLUSION

The results indicate that sunlight exposure may not be associated with increased risk of AMD based on current published data.

Authors+Show Affiliations

Hangzhou Hospital for the Prevention and Treatment of Occupational Diseases, Zhejiang, Hangzhou, China. zhjwood@163.com.Department of Ophthalmology, College of Medicine, the 2nd Affiliated Hospital of Zhejiang University, Zhejiang, Hangzhou, China.Hangzhou Hospital for the Prevention and Treatment of Occupational Diseases, Zhejiang, Hangzhou, China.Department of Ophthalmology, College of Medicine, the 2nd Affiliated Hospital of Zhejiang University, Zhejiang, Hangzhou, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

30572865

Citation

Zhou, Hongjie, et al. "Association Between Sunlight Exposure and Risk of Age-related Macular Degeneration: a Meta-analysis." BMC Ophthalmology, vol. 18, no. 1, 2018, p. 331.
Zhou H, Zhang H, Yu A, et al. Association between sunlight exposure and risk of age-related macular degeneration: a meta-analysis. BMC Ophthalmol. 2018;18(1):331.
Zhou, H., Zhang, H., Yu, A., & Xie, J. (2018). Association between sunlight exposure and risk of age-related macular degeneration: a meta-analysis. BMC Ophthalmology, 18(1), p. 331. doi:10.1186/s12886-018-1004-y.
Zhou H, et al. Association Between Sunlight Exposure and Risk of Age-related Macular Degeneration: a Meta-analysis. BMC Ophthalmol. 2018 Dec 20;18(1):331. PubMed PMID: 30572865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between sunlight exposure and risk of age-related macular degeneration: a meta-analysis. AU - Zhou,Hongjie, AU - Zhang,Huina, AU - Yu,Aiqing, AU - Xie,Jiajun, Y1 - 2018/12/20/ PY - 2018/05/20/received PY - 2018/12/10/accepted PY - 2018/12/22/entrez PY - 2018/12/24/pubmed PY - 2019/1/25/medline KW - Macular degeneration KW - Meta-analysis KW - Risk factor KW - Sunlight SP - 331 EP - 331 JF - BMC ophthalmology JO - BMC Ophthalmol VL - 18 IS - 1 N2 - BACKGROUND: A substantial number of epidemiological studies have investigated the possible associations between sunlight exposure and Age-related Macular Degeneration (AMD), but the results from studies are inconsistent. The aim of this meta-analysis was to evaluate the association between sunlight exposure and the risk of AMD. METHODS: Relevant studies were searched using databases including PubMed, EMBASE, and Web of Science database. Two authors independently extracted data and assessed study quality. The random-effects model was used to calculate the pooled covariates-adjusted odds ratio (OR). Subgroup analyses based on study design, stage of AMD, method of exposure assessment, and study latitude were carried out. The heterogeneity across the studies was tested, as was publication bias. RESULTS: Fourteen eligible studies including 43,934 individuals based on the inclusion criteria were analyzed. The pooled OR for sunlight exposure and AMD was 1.10 (95% CI = 0.98-1.23). In addition, similar insignificant results were observed in further subgroup analyses based on stage of AMD, method of exposure assessment, and study latitude. Sun-avoidance behavior did not decrease the risk of AMD (OR = 1.12, 95% CI = 0.76-1.67). Moderate heterogeneity was observed in most of analyses. CONCLUSION: The results indicate that sunlight exposure may not be associated with increased risk of AMD based on current published data. SN - 1471-2415 UR - https://www.unboundmedicine.com/medline/citation/30572865/Association_between_sunlight_exposure_and_risk_of_age_related_macular_degeneration:_a_meta_analysis_ L2 - https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-018-1004-y DB - PRIME DP - Unbound Medicine ER -