Tags

Type your tag names separated by a space and hit enter

Normal vitamin D and mineral metabolism in essential hypertension.
Am J Med Sci 1988; 296(4):252-9AJ

Abstract

The effects of dietary sodium upon serum and urinary calcium and selected vitamin D metabolites were studied in two groups (n = 10 each) of age and gender matched, white normotensive subjects and patients with normal-renin hypertension. Isocaloric diets were consumed on a metabolic ward with sequential daily sodium intake of 109 meq for 5 days and 9 meq and 259 meq for 6 days each. Values for serum and urinary calcium, phosphorus, magnesium and electrolytes, creatinine clearance, plasma immunoreactive parathyroid hormone, and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were similar in both study groups on each diet. Measurements of plasma renin activity and serum aldosterone levels were higher in the hypertensive than in the normotensive group on each diet (p less than .05-.01). Serum 1,25-dihydroxyvitamin D and urinary calcium increased on the high sodium diet in the normotensive (p less than .05) and the hypertensive groups (p less than .01). When the data for normotensive subjects and hypertensive patients were pooled by gender, males had a 1 1/2 to 3 times the urinary calcium excretion than females, regardless of diet. The present study indicates that there are no differences in the selected components of calcium and vitamin D metabolism in response to sodium intake in patients with essential hypertension and normal plasma renin activity as compared to normal controls.

Authors+Show Affiliations

Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3057908

Citation

Hughes, G S., et al. "Normal Vitamin D and Mineral Metabolism in Essential Hypertension." The American Journal of the Medical Sciences, vol. 296, no. 4, 1988, pp. 252-9.
Hughes GS, Oexmann MJ, Margolius HS, et al. Normal vitamin D and mineral metabolism in essential hypertension. Am J Med Sci. 1988;296(4):252-9.
Hughes, G. S., Oexmann, M. J., Margolius, H. S., Epstein, S., & Bell, N. H. (1988). Normal vitamin D and mineral metabolism in essential hypertension. The American Journal of the Medical Sciences, 296(4), pp. 252-9.
Hughes GS, et al. Normal Vitamin D and Mineral Metabolism in Essential Hypertension. Am J Med Sci. 1988;296(4):252-9. PubMed PMID: 3057908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal vitamin D and mineral metabolism in essential hypertension. AU - Hughes,G S,Jr AU - Oexmann,M J, AU - Margolius,H S, AU - Epstein,S, AU - Bell,N H, PY - 1988/10/1/pubmed PY - 2001/3/28/medline PY - 1988/10/1/entrez SP - 252 EP - 9 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 296 IS - 4 N2 - The effects of dietary sodium upon serum and urinary calcium and selected vitamin D metabolites were studied in two groups (n = 10 each) of age and gender matched, white normotensive subjects and patients with normal-renin hypertension. Isocaloric diets were consumed on a metabolic ward with sequential daily sodium intake of 109 meq for 5 days and 9 meq and 259 meq for 6 days each. Values for serum and urinary calcium, phosphorus, magnesium and electrolytes, creatinine clearance, plasma immunoreactive parathyroid hormone, and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were similar in both study groups on each diet. Measurements of plasma renin activity and serum aldosterone levels were higher in the hypertensive than in the normotensive group on each diet (p less than .05-.01). Serum 1,25-dihydroxyvitamin D and urinary calcium increased on the high sodium diet in the normotensive (p less than .05) and the hypertensive groups (p less than .01). When the data for normotensive subjects and hypertensive patients were pooled by gender, males had a 1 1/2 to 3 times the urinary calcium excretion than females, regardless of diet. The present study indicates that there are no differences in the selected components of calcium and vitamin D metabolism in response to sodium intake in patients with essential hypertension and normal plasma renin activity as compared to normal controls. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/3057908/Normal_vitamin_D_and_mineral_metabolism_in_essential_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(15)40862-6 DB - PRIME DP - Unbound Medicine ER -