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Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy.
J Cardiovasc Comput Tomogr. 2019 Mar - Apr; 13(2):142-147.JC

Abstract

BACKGROUND

Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA).

METHODS

A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM).

RESULTS

During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967-1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126-2.375; p = 0.010).

CONCLUSION

DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors.

CLINICAL TRIAL REGISTRATION

ClinicalTrials.govNCT02803411.

Authors+Show Affiliations

Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea; Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea.Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea.Department of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Department of Cardiology, Catholic Kwandong University International St. Mary's Hospital, Incheon, South Korea.Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Department of Cardiology, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, South Korea.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany.Seoul National University Hospital, Seoul, South Korea.Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea.Centro Cardiologico Monzino, IRCCS, Milan, Italy.Centro Cardiologico Monzino, IRCCS, Milan, Italy.Centro Cardiologico Monzino, IRCCS, Milan, Italy.Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, CA, USA.Department of Radiology, Casa de Saude São Jose, Rio de Janeiro, Brazil.Department of Radiology, Seoul National University Bundang Hospital, Sungnam, South Korea.Cardiovascular Imaging Center, SDN IRCCS, Naples, Italy.Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy.UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisboa, Portugal.Department of Medicine and Radiology, University of British Columbia, Vancouver, BC, Canada.Department of Cardiology, National Health Insurance Service Ilsan Hospital, South Korea.Department of Cardiology, Busan University Hospital, Busan, South Korea.Department of Pathology, CVPath Institute, Gaithersburg, MD, USA.Department of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.Department of Imaging and Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.Icahn School of Medicine at Mount Sinai, Mount Sinai Heart, Zena and Michael A. Wiener Cardiovascular Institute, And Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, New York, NY, USA.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. Electronic address: hjchang@yuhs.ac.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study

Language

eng

PubMed ID

30580992

Citation

Won, Ki-Bum, et al. "Longitudinal Assessment of Coronary Plaque Volume Change Related to Glycemic Status Using Serial Coronary Computed Tomography Angiography: a PARADIGM (Progression of AtheRosclerotic PlAque DetermIned By Computed TomoGraphic Angiography Imaging) Substudy." Journal of Cardiovascular Computed Tomography, vol. 13, no. 2, 2019, pp. 142-147.
Won KB, Lee SE, Lee BK, et al. Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy. J Cardiovasc Comput Tomogr. 2019;13(2):142-147.
Won, K. B., Lee, S. E., Lee, B. K., Park, H. B., Heo, R., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y. J., Sung, J. M., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Chun, E. J., Cademartiri, F., Maffei, E., ... Chang, H. J. (2019). Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy. Journal of Cardiovascular Computed Tomography, 13(2), 142-147. https://doi.org/10.1016/j.jcct.2018.12.002
Won KB, et al. Longitudinal Assessment of Coronary Plaque Volume Change Related to Glycemic Status Using Serial Coronary Computed Tomography Angiography: a PARADIGM (Progression of AtheRosclerotic PlAque DetermIned By Computed TomoGraphic Angiography Imaging) Substudy. J Cardiovasc Comput Tomogr. 2019 Mar - Apr;13(2):142-147. PubMed PMID: 30580992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy. AU - Won,Ki-Bum, AU - Lee,Sang-Eun, AU - Lee,Byoung Kwon, AU - Park,Hyung-Bok, AU - Heo,Ran, AU - Rizvi,Asim, AU - Lin,Fay Y, AU - Kumar,Amit, AU - Hadamitzky,Martin, AU - Kim,Yong-Jin, AU - Sung,Ji Min, AU - Conte,Edoardo, AU - Andreini,Daniele, AU - Pontone,Gianluca, AU - Budoff,Matthew J, AU - Gottlieb,Ilan, AU - Chun,Eun Ju, AU - Cademartiri,Filippo, AU - Maffei,Erica, AU - Marques,Hugo, AU - Leipsic,Jonathon A, AU - Shin,Sanghoon, AU - Choi,Jung Hyun, AU - Virmani,Renu, AU - Samady,Habib, AU - Chinnaiyan,Kavitha, AU - Raff,Gilbert L, AU - Stone,Peter H, AU - Berman,Daniel S, AU - Narula,Jagat, AU - Shaw,Leslee J, AU - Bax,Jeroen J, AU - Min,James K, AU - Chang,Hyuk-Jae, Y1 - 2018/12/17/ PY - 2018/06/11/received PY - 2018/11/29/revised PY - 2018/12/16/accepted PY - 2018/12/26/pubmed PY - 2019/6/14/medline PY - 2018/12/25/entrez KW - Coronary atherosclerosis KW - Coronary computed tomography angiography KW - Pre-diabetes SP - 142 EP - 147 JF - Journal of cardiovascular computed tomography JO - J Cardiovasc Comput Tomogr VL - 13 IS - 2 N2 - BACKGROUND: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). METHODS: A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). RESULTS: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967-1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126-2.375; p = 0.010). CONCLUSION: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. CLINICAL TRIAL REGISTRATION: ClinicalTrials.govNCT02803411. SN - 1876-861X UR - https://www.unboundmedicine.com/medline/citation/30580992/Longitudinal_assessment_of_coronary_plaque_volume_change_related_to_glycemic_status_using_serial_coronary_computed_tomography_angiography:_A_PARADIGM__Progression_of_AtheRosclerotic_PlAque_DetermIned_by_Computed_TomoGraphic_Angiography_Imaging__substudy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1934-5925(18)30181-3 DB - PRIME DP - Unbound Medicine ER -