Tags

Type your tag names separated by a space and hit enter

Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients.
J Formos Med Assoc. 2019 Feb; 118(2):565-571.JF

Abstract

BACKGROUND/PURPOSE

Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA-AG) patients.

METHODS

The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA-AG patients, and 532 healthy control subjects.

RESULTS

Both 284 GPCA+AG and 780 GPCA-AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA-AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA-AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA-AG patients.

CONCLUSION

The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA-AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients.

Authors+Show Affiliations

Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30581105

Citation

Chiang, Chun-Pin, et al. "Anemia, Hematinic Deficiencies, and Hyperhomocysteinemia in Gastric Parietal Cell Antibody-positive and -negative Atrophic Glossitis Patients." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 118, no. 2, 2019, pp. 565-571.
Chiang CP, Chang JY, Wang YP, et al. Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients. J Formos Med Assoc. 2019;118(2):565-571.
Chiang, C. P., Chang, J. Y., Wang, Y. P., Wu, Y. H., Wu, Y. C., & Sun, A. (2019). Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 118(2), 565-571. https://doi.org/10.1016/j.jfma.2018.12.005
Chiang CP, et al. Anemia, Hematinic Deficiencies, and Hyperhomocysteinemia in Gastric Parietal Cell Antibody-positive and -negative Atrophic Glossitis Patients. J Formos Med Assoc. 2019;118(2):565-571. PubMed PMID: 30581105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients. AU - Chiang,Chun-Pin, AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Wu,Yu-Hsueh, AU - Wu,Yang-Che, AU - Sun,Andy, Y1 - 2018/12/21/ PY - 2018/11/16/received PY - 2018/12/05/accepted PY - 2018/12/26/pubmed PY - 2019/5/2/medline PY - 2018/12/25/entrez KW - Anemia KW - Atrophic glossitis KW - Gastric parietal cell antibody KW - Hyperhomocysteinemia KW - Vitamin B12 deficiency SP - 565 EP - 571 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 118 IS - 2 N2 - BACKGROUND/PURPOSE: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA-AG) patients. METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA-AG patients, and 532 healthy control subjects. RESULTS: Both 284 GPCA+AG and 780 GPCA-AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA-AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA-AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA-AG patients. CONCLUSION: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA+AG and GPCA-AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA+AG patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/30581105/Anemia_hematinic_deficiencies_and_hyperhomocysteinemia_in_gastric_parietal_cell_antibody_positive_and__negative_atrophic_glossitis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(18)30805-2 DB - PRIME DP - Unbound Medicine ER -