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Protective role of Spirulina platensis against UVA-induced haemato-biochemical and cellular alterations in Clarias gariepinus.
J Photochem Photobiol B. 2019 Feb; 191:59-64.JP

Abstract

Recently, it has become widely recognized that ultraviolet A (UVA) exposure is harmful for both aquatic and terrestrial organisms. Many studies have reported the effects of UVA on aquatic animals, especially fish, but little is known about the antioxidant role of microalgae in ameliorating the negative effects of UVA exposure. Recently, there has been great interest in using Spirulina platensis (SP) as a dietary antioxidant agent. Therefore, this study aimed to investigate the protective role of SP against UVA-induced effects by analysing haemato-biochemical alterations and erythrocyte cytotoxic and genotoxic biomarkers in African catfish (Clarias gariepinus). Fish were exposed to UVA, UVA + 100 mg/L SP extract, UVA + 200 mg/L SP extract for 3 days (UVA exposure: 1 h/day), and were not subjected to treatment (control group). The results showed the presence of some morphological malformations in red blood cells (RBCs) after UVA exposure. Additionally, nuclear abnormalities, including micronuclei, were observed. UVA induced alterations in most of the haemato-biochemical indices. Adding SP to the fish aquaria restored the haemato-biochemical parameters to their control values. In addition, SP repaired cellular damage in a dose-dependent manner. We conclude that SP plays a modulatory role in preventing and/or repairing the haemotoxic effects induced by UVA.

Authors+Show Affiliations

Zoology Department, Faculty of Science, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt.Zoology Department, Faculty of Science, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt. Electronic address: mohamedhamedsayed239@gmail.com.Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30583267

Citation

Osman, Alaa, et al. "Protective Role of Spirulina Platensis Against UVA-induced Haemato-biochemical and Cellular Alterations in Clarias Gariepinus." Journal of Photochemistry and Photobiology. B, Biology, vol. 191, 2019, pp. 59-64.
Osman A, Hamed M, Sayed A. Protective role of Spirulina platensis against UVA-induced haemato-biochemical and cellular alterations in Clarias gariepinus. J Photochem Photobiol B. 2019;191:59-64.
Osman, A., Hamed, M., & Sayed, A. (2019). Protective role of Spirulina platensis against UVA-induced haemato-biochemical and cellular alterations in Clarias gariepinus. Journal of Photochemistry and Photobiology. B, Biology, 191, 59-64. https://doi.org/10.1016/j.jphotobiol.2018.12.013
Osman A, Hamed M, Sayed A. Protective Role of Spirulina Platensis Against UVA-induced Haemato-biochemical and Cellular Alterations in Clarias Gariepinus. J Photochem Photobiol B. 2019;191:59-64. PubMed PMID: 30583267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of Spirulina platensis against UVA-induced haemato-biochemical and cellular alterations in Clarias gariepinus. AU - Osman,Alaa, AU - Hamed,Mohamed, AU - Sayed,Alaa, Y1 - 2018/12/18/ PY - 2018/11/06/received PY - 2018/12/10/revised PY - 2018/12/17/accepted PY - 2018/12/26/pubmed PY - 2019/4/2/medline PY - 2018/12/25/entrez KW - Acanthocytes KW - Anion gap KW - Catfish KW - Micronucleus KW - SP KW - UVA SP - 59 EP - 64 JF - Journal of photochemistry and photobiology. B, Biology JO - J Photochem Photobiol B VL - 191 N2 - Recently, it has become widely recognized that ultraviolet A (UVA) exposure is harmful for both aquatic and terrestrial organisms. Many studies have reported the effects of UVA on aquatic animals, especially fish, but little is known about the antioxidant role of microalgae in ameliorating the negative effects of UVA exposure. Recently, there has been great interest in using Spirulina platensis (SP) as a dietary antioxidant agent. Therefore, this study aimed to investigate the protective role of SP against UVA-induced effects by analysing haemato-biochemical alterations and erythrocyte cytotoxic and genotoxic biomarkers in African catfish (Clarias gariepinus). Fish were exposed to UVA, UVA + 100 mg/L SP extract, UVA + 200 mg/L SP extract for 3 days (UVA exposure: 1 h/day), and were not subjected to treatment (control group). The results showed the presence of some morphological malformations in red blood cells (RBCs) after UVA exposure. Additionally, nuclear abnormalities, including micronuclei, were observed. UVA induced alterations in most of the haemato-biochemical indices. Adding SP to the fish aquaria restored the haemato-biochemical parameters to their control values. In addition, SP repaired cellular damage in a dose-dependent manner. We conclude that SP plays a modulatory role in preventing and/or repairing the haemotoxic effects induced by UVA. SN - 1873-2682 UR - https://www.unboundmedicine.com/medline/citation/30583267/Protective_role_of_Spirulina_platensis_against_UVA_induced_haemato_biochemical_and_cellular_alterations_in_Clarias_gariepinus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1011-1344(18)31249-1 DB - PRIME DP - Unbound Medicine ER -