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Secondary extramedullary plasmacytoma of sigmoid colon in a patient with multiple myeloma: a case report.
J Med Case Rep. 2018 Dec 25; 12(1):379.JM

Abstract

BACKGROUND

Extramedullary plasmacytoma is an uncommon tumor that most often involves the nasopharynx or upper respiratory tract. Extramedullary plasmacytoma is a type of plasma cell neoplasm that can present as a primary tumor or secondary to another plasma cell neoplasm, such as multiple myeloma. Secondary extramedullary plasmacytoma is usually noted in the advanced stages of the disease. Involvement of the gastrointestinal tract occurs in approximately 10% of cases.

CASE PRESENTATION

A 71-year-old Caucasian woman with known diverticular disease of the colon and multiple myeloma diagnosed 3 years previously, with monoclonal bands of immunoglobulin A, lambda light chains, and multiple osteolytic lesions, presented to our hospital with abdominal pain, abdominal discomfort, and pneumoperitoneum. She underwent left colectomy for diverticulitis with perforation, and an extramedullary secondary colonic plasmacytoma was found in histopathological examination of the sigmoid colon.

CONCLUSIONS

Plasmacytoma is known to occur in extraosseous sites. The stomach and small intestine are the most commonly involved sites in the gastrointestinal tract. Secondary extramedullary plasmacytoma of the colon is rare. Colonic plasmacytoma may have varying clinical presentations, such as inflammatory bowel disease and multiple colonic strictures. Although these cases are rare, treating physicians as well as radiologists, pathologists, and surgeons should be aware of this entity.

Authors+Show Affiliations

Computed Tomography Department, Konstantpouleio General Hospital Nea Ionia, Athens, Greece. dfagrezos@gmail.com.Surgery Department, Konstantpouleio General Hospital Nea Ionia, Athens, Greece.Gastroenterology Department, Konstantpouleio General Hospital Nea Ionia, Athens, Greece.Pathology Department, Konstantopouleio General Hospital Nea Ionia, Athens, Greece.Radiology Department, Konstantpouleio General Hospital Nea Ionia, Athens, Greece.Pathology Department, Konstantopouleio General Hospital Nea Ionia, Athens, Greece.Computed Tomography Department, Konstantpouleio General Hospital Nea Ionia, Athens, Greece.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30583721

Citation

Fagkrezos, Dimitris, et al. "Secondary Extramedullary Plasmacytoma of Sigmoid Colon in a Patient With Multiple Myeloma: a Case Report." Journal of Medical Case Reports, vol. 12, no. 1, 2018, p. 379.
Fagkrezos D, Manes K, Paraskeva K, et al. Secondary extramedullary plasmacytoma of sigmoid colon in a patient with multiple myeloma: a case report. J Med Case Rep. 2018;12(1):379.
Fagkrezos, D., Manes, K., Paraskeva, K., Lenos, M., Triantopoulou, C., Apessou, D., & Maniatis, P. (2018). Secondary extramedullary plasmacytoma of sigmoid colon in a patient with multiple myeloma: a case report. Journal of Medical Case Reports, 12(1), 379. https://doi.org/10.1186/s13256-018-1888-4
Fagkrezos D, et al. Secondary Extramedullary Plasmacytoma of Sigmoid Colon in a Patient With Multiple Myeloma: a Case Report. J Med Case Rep. 2018 Dec 25;12(1):379. PubMed PMID: 30583721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Secondary extramedullary plasmacytoma of sigmoid colon in a patient with multiple myeloma: a case report. AU - Fagkrezos,Dimitris, AU - Manes,Konstantinos, AU - Paraskeva,Konstantina, AU - Lenos,Michalis, AU - Triantopoulou,Charikleia, AU - Apessou,Dimitra, AU - Maniatis,Petros, Y1 - 2018/12/25/ PY - 2018/08/30/received PY - 2018/10/22/accepted PY - 2018/12/26/entrez PY - 2018/12/26/pubmed PY - 2019/5/7/medline KW - Multiple myeloma KW - Oncology KW - Secondary extramedullary plasmacytoma KW - Sigmoid colon SP - 379 EP - 379 JF - Journal of medical case reports JO - J Med Case Rep VL - 12 IS - 1 N2 - BACKGROUND: Extramedullary plasmacytoma is an uncommon tumor that most often involves the nasopharynx or upper respiratory tract. Extramedullary plasmacytoma is a type of plasma cell neoplasm that can present as a primary tumor or secondary to another plasma cell neoplasm, such as multiple myeloma. Secondary extramedullary plasmacytoma is usually noted in the advanced stages of the disease. Involvement of the gastrointestinal tract occurs in approximately 10% of cases. CASE PRESENTATION: A 71-year-old Caucasian woman with known diverticular disease of the colon and multiple myeloma diagnosed 3 years previously, with monoclonal bands of immunoglobulin A, lambda light chains, and multiple osteolytic lesions, presented to our hospital with abdominal pain, abdominal discomfort, and pneumoperitoneum. She underwent left colectomy for diverticulitis with perforation, and an extramedullary secondary colonic plasmacytoma was found in histopathological examination of the sigmoid colon. CONCLUSIONS: Plasmacytoma is known to occur in extraosseous sites. The stomach and small intestine are the most commonly involved sites in the gastrointestinal tract. Secondary extramedullary plasmacytoma of the colon is rare. Colonic plasmacytoma may have varying clinical presentations, such as inflammatory bowel disease and multiple colonic strictures. Although these cases are rare, treating physicians as well as radiologists, pathologists, and surgeons should be aware of this entity. SN - 1752-1947 UR - https://www.unboundmedicine.com/medline/citation/30583721/Secondary_extramedullary_plasmacytoma_of_sigmoid_colon_in_a_patient_with_multiple_myeloma:_a_case_report_ L2 - https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-018-1888-4 DB - PRIME DP - Unbound Medicine ER -