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Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection.
Jpn J Infect Dis. 2019 May 23; 72(3):160-167.JJ

Abstract

There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea. This hospital-based retrospective study compared MERS-CoV-positive and MERS-CoV-negative patients. A total of seven positive patients and 55 negative patients with a median age of 43 years (P = 0.845) were included. No statistical differences were observed with respect to their sex and the presence of comorbidities. At the time of admission, headache (28.6% vs. 3.6%; odds ratio [OR], 10.60; 95% confidence interval [CI], 1.22-92.27), myalgia (57.1% vs. 9.1%; OR, 13.33; 95% CI, 2.30-77.24), and diarrhea (57.1% vs. 14.5%; OR, 7.83; 95% CI, 1.47-41.79) were common among MERS-CoV-positive patients. MERS-CoV-positive patients were more likely to have a low platelet count (164 ± 76.57 vs. 240 ± 79.87) and eosinophil (0.27 ± 0.43 vs. 2.13 ± 2.01; P = 0.003). Chest radiography with diffuse bronchopneumonia was more frequent in MERS-CoV-positive patients than in negative patients (100% vs. 62.5%; P = 0.491). The symptoms of headache, myalgia, and diarrhea, as well as laboratory characteristics, including low platelet counts and eosinophil, and chest X-ray showing diffuse bronchopneumonia might enhance the ability to detect patients in South Korea infected with MERS-CoV.

Authors+Show Affiliations

Korea Centers for Disease Control and Prevention. Department of Health Policy, Health & Welfare Bureau. Department of Preventive Medicine, Korea University College of Medicine.Seoul Metropolitan Government Civil Health Bueau.Korea Armed Forces Nursing Academy.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Tuberculosis, Seobuk Hospital.Department of Preventive Medicine, Korea University College of Medicine. Department of Tuberculosis, Seobuk Hospital.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30584196

Citation

Hwang, Se-Min, et al. "Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection." Japanese Journal of Infectious Diseases, vol. 72, no. 3, 2019, pp. 160-167.
Hwang SM, Na BJ, Jung Y, et al. Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection. Jpn J Infect Dis. 2019;72(3):160-167.
Hwang, S. M., Na, B. J., Jung, Y., Lim, H. S., Seo, J. E., Park, S. A., Cho, Y. S., Song, E. H., Seo, J. Y., Kim, S. R., Lee, G. Y., Kim, S. J., Park, Y. S., & Seo, H. (2019). Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection. Japanese Journal of Infectious Diseases, 72(3), 160-167. https://doi.org/10.7883/yoken.JJID.2018.187
Hwang SM, et al. Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection. Jpn J Infect Dis. 2019 May 23;72(3):160-167. PubMed PMID: 30584196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection. AU - Hwang,Se-Min, AU - Na,Baeg-Ju, AU - Jung,Yoomi, AU - Lim,Hyun-Suk, AU - Seo,Jeong-Eun, AU - Park,Shin-Ae, AU - Cho,Young-Soo, AU - Song,Eun-Hyang, AU - Seo,Ji-Yeon, AU - Kim,Sung-Ryul, AU - Lee,Gang-Young, AU - Kim,Soon-Ja, AU - Park,Young-Suk, AU - Seo,Haesook, Y1 - 2018/12/25/ PY - 2018/12/26/pubmed PY - 2019/7/13/medline PY - 2018/12/26/entrez KW - MERS KW - coronavirus KW - pneumonia SP - 160 EP - 167 JF - Japanese journal of infectious diseases JO - Jpn J Infect Dis VL - 72 IS - 3 N2 - There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea. This hospital-based retrospective study compared MERS-CoV-positive and MERS-CoV-negative patients. A total of seven positive patients and 55 negative patients with a median age of 43 years (P = 0.845) were included. No statistical differences were observed with respect to their sex and the presence of comorbidities. At the time of admission, headache (28.6% vs. 3.6%; odds ratio [OR], 10.60; 95% confidence interval [CI], 1.22-92.27), myalgia (57.1% vs. 9.1%; OR, 13.33; 95% CI, 2.30-77.24), and diarrhea (57.1% vs. 14.5%; OR, 7.83; 95% CI, 1.47-41.79) were common among MERS-CoV-positive patients. MERS-CoV-positive patients were more likely to have a low platelet count (164 ± 76.57 vs. 240 ± 79.87) and eosinophil (0.27 ± 0.43 vs. 2.13 ± 2.01; P = 0.003). Chest radiography with diffuse bronchopneumonia was more frequent in MERS-CoV-positive patients than in negative patients (100% vs. 62.5%; P = 0.491). The symptoms of headache, myalgia, and diarrhea, as well as laboratory characteristics, including low platelet counts and eosinophil, and chest X-ray showing diffuse bronchopneumonia might enhance the ability to detect patients in South Korea infected with MERS-CoV. SN - 1884-2836 UR - https://www.unboundmedicine.com/medline/citation/30584196/Clinical_and_Laboratory_Findings_of_Middle_East_Respiratory_Syndrome_Coronavirus_Infection_ L2 - https://dx.doi.org/10.7883/yoken.JJID.2018.187 DB - PRIME DP - Unbound Medicine ER -