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Comparison of Fellow Eyes of Acute Primary Angle Closure and Phacomorphic Angle Closure.
J Glaucoma. 2019 03; 28(3):194-200.JG

Abstract

PURPOSE

To compare anterior segment parameters in fellow eyes of acute primary angle closure (APAC) and fellow eyes of phacomorphic angle closure (AC) and to identify parameters that could be used to differentiate fellow eyes of the 2 entities.

METHODS

This cross-sectional study included 55 unaffected fellow eyes of APAC, 48 unaffected fellow eyes of phacomorphic AC, and 52 eyes of control subjects. All patients underwent anterior segment optical coherence tomography imaging. Anterior chamber depth, anterior chamber area, anterior chamber width (ACW), iris thickness (IT), iris curvature, lens vault (LV), and angle parameters including angle-opening distance (AOD750) were measured in qualified images using customized software and compared among the groups using a linear mixed model.

RESULTS

Fellow eyes of APAC had the smallest axial length, AOD, anterior chamber depth, anterior chamber area, ACW, and the greatest LV, and IT (P≤0.002 for all), followed by fellow eyes of phacomorphic AC, after adjustment for age, sex, and pupil diameter. IT and curvature were comparable between fellow eyes of phacomorphic AC and controls. Angle parameters had the highest area of the receiver-operator characteristic curve for discrimination of fellow eyes of APAC eyes and phacomorphic AC (0.795, P=0.001 for AOD750). In a multivariable analysis, AOD750<0.161 µm [odds ratio (OR), 23.43; P=0.001], LV>768.6 µm (OR, 16.76; P=0.001), ACW<11.07 mm (OR, 8.93; P=0.023) and younger age (P=0.001) were the factors that discriminated fellow eyes of APAC from phacomorphic AC.

CONCLUSIONS

Differences in ocular biometric parameters can be detected between fellow eyes of APAC and phacomorphic AC. Narrower angle, more anteriorly displaced lens, and thicker iris are the main parameters that distinguish fellow eyes of APAC and phacomorphic AC.

Authors+Show Affiliations

Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, San Diego. Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.Case Western Reserve University School of Medicine, Cleveland, OH.University of California, San Francisco, San Francisco, CA.Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, San Diego.

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30585936

Citation

Moghimi, Sasan, et al. "Comparison of Fellow Eyes of Acute Primary Angle Closure and Phacomorphic Angle Closure." Journal of Glaucoma, vol. 28, no. 3, 2019, pp. 194-200.
Moghimi S, Fathollahzadeh N, Chen R, et al. Comparison of Fellow Eyes of Acute Primary Angle Closure and Phacomorphic Angle Closure. J Glaucoma. 2019;28(3):194-200.
Moghimi, S., Fathollahzadeh, N., Chen, R., Lin, S. C., & Weinreb, R. N. (2019). Comparison of Fellow Eyes of Acute Primary Angle Closure and Phacomorphic Angle Closure. Journal of Glaucoma, 28(3), 194-200. https://doi.org/10.1097/IJG.0000000000001167
Moghimi S, et al. Comparison of Fellow Eyes of Acute Primary Angle Closure and Phacomorphic Angle Closure. J Glaucoma. 2019;28(3):194-200. PubMed PMID: 30585936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Fellow Eyes of Acute Primary Angle Closure and Phacomorphic Angle Closure. AU - Moghimi,Sasan, AU - Fathollahzadeh,Navid, AU - Chen,Rebecca, AU - Lin,Shan C, AU - Weinreb,Robert N, PY - 2018/12/27/pubmed PY - 2020/3/14/medline PY - 2018/12/27/entrez SP - 194 EP - 200 JF - Journal of glaucoma JO - J. Glaucoma VL - 28 IS - 3 N2 - PURPOSE: To compare anterior segment parameters in fellow eyes of acute primary angle closure (APAC) and fellow eyes of phacomorphic angle closure (AC) and to identify parameters that could be used to differentiate fellow eyes of the 2 entities. METHODS: This cross-sectional study included 55 unaffected fellow eyes of APAC, 48 unaffected fellow eyes of phacomorphic AC, and 52 eyes of control subjects. All patients underwent anterior segment optical coherence tomography imaging. Anterior chamber depth, anterior chamber area, anterior chamber width (ACW), iris thickness (IT), iris curvature, lens vault (LV), and angle parameters including angle-opening distance (AOD750) were measured in qualified images using customized software and compared among the groups using a linear mixed model. RESULTS: Fellow eyes of APAC had the smallest axial length, AOD, anterior chamber depth, anterior chamber area, ACW, and the greatest LV, and IT (P≤0.002 for all), followed by fellow eyes of phacomorphic AC, after adjustment for age, sex, and pupil diameter. IT and curvature were comparable between fellow eyes of phacomorphic AC and controls. Angle parameters had the highest area of the receiver-operator characteristic curve for discrimination of fellow eyes of APAC eyes and phacomorphic AC (0.795, P=0.001 for AOD750). In a multivariable analysis, AOD750<0.161 µm [odds ratio (OR), 23.43; P=0.001], LV>768.6 µm (OR, 16.76; P=0.001), ACW<11.07 mm (OR, 8.93; P=0.023) and younger age (P=0.001) were the factors that discriminated fellow eyes of APAC from phacomorphic AC. CONCLUSIONS: Differences in ocular biometric parameters can be detected between fellow eyes of APAC and phacomorphic AC. Narrower angle, more anteriorly displaced lens, and thicker iris are the main parameters that distinguish fellow eyes of APAC and phacomorphic AC. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/30585936/Comparison_of_Fellow_Eyes_of_Acute_Primary_Angle_Closure_and_Phacomorphic_Angle_Closure_ L2 - https://doi.org/10.1097/IJG.0000000000001167 DB - PRIME DP - Unbound Medicine ER -