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A rare concurrence: Antibodies against Myelin Oligodendrocyte Glycoprotein and N-methyl-d-aspartate receptor in a child.
Mult Scler Relat Disord. 2019 Feb; 28:101-103.MS

Abstract

BACKGROUND

Myelin Oligodendrocyte Glycoprotein antibodies (MOG) may be used as a biomarker for diagnosis of many demyelinating diseases. Especially, patients of acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), aquaporin-4 (AQP4) seronegative neuromyelitis optica spectrum disorder (NMOSD), monophasic or recurrent optic neuritis (ON), transverse myelitis and N-methyl-d-aspartate (NMDA) receptor encephalitis (NMDARe) can overlap with Myelin Oligodendrocyte Glycoprotein antibodies. We present a child with autoimmune encephalitis in whom antibodies against Myelin Oligodendrocyte Glycoprotein (MOG) and N-methyl-d-aspartate receptor (NMDAR) were simultaneously detected. The clinical manifestation was characteristic of NMDAR encephalitis, and cranial and spinal magnetic resonance imaging showed no signs of encephalomyelitis. On the other hand, complete recovery within first days of steroid treatment was more compatible with the course of MOG antibody-related disease.

CONCLUSIONS

We emphasize the rarity of this antibody combination in children and suggest these patients, although clinically improved, may require longer follow-up due to the risk of recurrence of two autoimmune disorders.

Authors+Show Affiliations

Mersin University, Faculty of Medicine, Department of Pediatric Neurology, Mersin, Turkey. Electronic address: sarigeciliesra@gmail.com.Mersin University, Faculty of Medicine, Department of Pediatric Neurology, Mersin, Turkey. Electronic address: m_lt_m82@hotmail.com.Mersin University, Faculty of Medicine, Department of Pediatric Neurology, Mersin, Turkey. Electronic address: drmustafakomur@yahoo.com.Mersin University, Faculty of Medicine, Department of Pediatric Neurology, Mersin, Turkey. Electronic address: cetinokuyaz@gmail.com.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30590238

Citation

Sarigecili, Esra, et al. "A Rare Concurrence: Antibodies Against Myelin Oligodendrocyte Glycoprotein and N-methyl-d-aspartate Receptor in a Child." Multiple Sclerosis and Related Disorders, vol. 28, 2019, pp. 101-103.
Sarigecili E, Cobanogullari MD, Komur M, et al. A rare concurrence: Antibodies against Myelin Oligodendrocyte Glycoprotein and N-methyl-d-aspartate receptor in a child. Mult Scler Relat Disord. 2019;28:101-103.
Sarigecili, E., Cobanogullari, M. D., Komur, M., & Okuyaz, C. (2019). A rare concurrence: Antibodies against Myelin Oligodendrocyte Glycoprotein and N-methyl-d-aspartate receptor in a child. Multiple Sclerosis and Related Disorders, 28, 101-103. https://doi.org/10.1016/j.msard.2018.12.017
Sarigecili E, et al. A Rare Concurrence: Antibodies Against Myelin Oligodendrocyte Glycoprotein and N-methyl-d-aspartate Receptor in a Child. Mult Scler Relat Disord. 2019;28:101-103. PubMed PMID: 30590238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A rare concurrence: Antibodies against Myelin Oligodendrocyte Glycoprotein and N-methyl-d-aspartate receptor in a child. AU - Sarigecili,Esra, AU - Cobanogullari,Meltem Direk, AU - Komur,Mustafa, AU - Okuyaz,Cetin, Y1 - 2018/12/14/ PY - 2018/10/30/received PY - 2018/12/09/revised PY - 2018/12/13/accepted PY - 2018/12/28/pubmed PY - 2019/6/14/medline PY - 2018/12/28/entrez KW - Autoimmune encephalitis KW - Myelin Oligodendrocyte Glycoprotein (MOG) KW - N-methyl-d-aspartate receptor (NMDAR) SP - 101 EP - 103 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 28 N2 - BACKGROUND: Myelin Oligodendrocyte Glycoprotein antibodies (MOG) may be used as a biomarker for diagnosis of many demyelinating diseases. Especially, patients of acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), aquaporin-4 (AQP4) seronegative neuromyelitis optica spectrum disorder (NMOSD), monophasic or recurrent optic neuritis (ON), transverse myelitis and N-methyl-d-aspartate (NMDA) receptor encephalitis (NMDARe) can overlap with Myelin Oligodendrocyte Glycoprotein antibodies. We present a child with autoimmune encephalitis in whom antibodies against Myelin Oligodendrocyte Glycoprotein (MOG) and N-methyl-d-aspartate receptor (NMDAR) were simultaneously detected. The clinical manifestation was characteristic of NMDAR encephalitis, and cranial and spinal magnetic resonance imaging showed no signs of encephalomyelitis. On the other hand, complete recovery within first days of steroid treatment was more compatible with the course of MOG antibody-related disease. CONCLUSIONS: We emphasize the rarity of this antibody combination in children and suggest these patients, although clinically improved, may require longer follow-up due to the risk of recurrence of two autoimmune disorders. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/30590238/A_rare_concurrence:_Antibodies_against_Myelin_Oligodendrocyte_Glycoprotein_and_N_methyl_d_aspartate_receptor_in_a_child_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(18)30549-2 DB - PRIME DP - Unbound Medicine ER -