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Current Understanding of Humoral Immunity to Enterovirus D68.
J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S49-S53.JP

Abstract

Enterovirus D68 (EV-D68) is a pathogen that causes outbreaks of respiratory illness across the world, mostly in children, and can be especially severe in those with asthma. Clusters of acute flaccid myelitis, a poliomyelitis-like neuromuscular weakness syndrome, often occur concurrent with EV-D68 respiratory outbreaks. Seroepidemiologic studies have found that the serum of nearly everyone older than 2 to 5 years contains anti-EV-D68 neutralizing antibodies, which suggests that EV-D68 is a ubiquitous pathogen of childhood. However, knowledge of the viral epitopes against which the humoral immune response is directed is only inferred from previous studies of related viruses. Although neutralizing antibodies protect newborn mice from lethal EV-D68 inoculation via nonphysiologic routes, cotton rats have a mixed phenotype of both benefit and possible exacerbation when inoculated intranasally. The human antibody response to EV-D68 needs to be studied further to clarify the role of antibodies in protection versus pathogenesis, which might differ among respiratory and neurologic disease phenotypes.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee. Departments of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee. Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30590621

Citation

Vogt, Matthew R., and James E. Crowe. "Current Understanding of Humoral Immunity to Enterovirus D68." Journal of the Pediatric Infectious Diseases Society, vol. 7, no. suppl_2, 2018, pp. S49-S53.
Vogt MR, Crowe JE. Current Understanding of Humoral Immunity to Enterovirus D68. J Pediatric Infect Dis Soc. 2018;7(suppl_2):S49-S53.
Vogt, M. R., & Crowe, J. E. (2018). Current Understanding of Humoral Immunity to Enterovirus D68. Journal of the Pediatric Infectious Diseases Society, 7(suppl_2), S49-S53. https://doi.org/10.1093/jpids/piy124
Vogt MR, Crowe JE. Current Understanding of Humoral Immunity to Enterovirus D68. J Pediatric Infect Dis Soc. 2018 Dec 26;7(suppl_2):S49-S53. PubMed PMID: 30590621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current Understanding of Humoral Immunity to Enterovirus D68. AU - Vogt,Matthew R, AU - Crowe,James E,Jr PY - 2018/12/28/entrez PY - 2018/12/28/pubmed PY - 2019/1/12/medline SP - S49 EP - S53 JF - Journal of the Pediatric Infectious Diseases Society JO - J Pediatric Infect Dis Soc VL - 7 IS - suppl_2 N2 - Enterovirus D68 (EV-D68) is a pathogen that causes outbreaks of respiratory illness across the world, mostly in children, and can be especially severe in those with asthma. Clusters of acute flaccid myelitis, a poliomyelitis-like neuromuscular weakness syndrome, often occur concurrent with EV-D68 respiratory outbreaks. Seroepidemiologic studies have found that the serum of nearly everyone older than 2 to 5 years contains anti-EV-D68 neutralizing antibodies, which suggests that EV-D68 is a ubiquitous pathogen of childhood. However, knowledge of the viral epitopes against which the humoral immune response is directed is only inferred from previous studies of related viruses. Although neutralizing antibodies protect newborn mice from lethal EV-D68 inoculation via nonphysiologic routes, cotton rats have a mixed phenotype of both benefit and possible exacerbation when inoculated intranasally. The human antibody response to EV-D68 needs to be studied further to clarify the role of antibodies in protection versus pathogenesis, which might differ among respiratory and neurologic disease phenotypes. SN - 2048-7207 UR - https://www.unboundmedicine.com/medline/citation/30590621/Current_Understanding_of_Humoral_Immunity_to_Enterovirus_D68_ L2 - https://academic.oup.com/jpids/article-lookup/doi/10.1093/jpids/piy124 DB - PRIME DP - Unbound Medicine ER -