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The Association of Motor Skills and Adaptive Functioning in XXY/Klinefelter and XXYY Syndromes.
Phys Occup Ther Pediatr. 2019; 39(4):446-459.PO

Abstract

Aims: Klinefelter (XXY) and XXYY syndromes are genetic disorders in males characterized by additional sex chromosomes compared to the typical male karyotype of 46, XY. Both conditions have been previously associated with motor delays and motor skills deficits. We aimed to describe and compare motor skills in males with XXY and XXYY syndromes, and to analyze associations with age, cognitive abilities, and adaptive functioning. Methods: Sixty-four males with XXY and 46 males with XXYY, ages 4-20 were evaluated using the Beery Test of Visual Motor Integration and the Bruininks-Oseretsky Test of Motor Proficiency - 2nd Edition assessments, Vineland-2 adaptive scales, and cognitive testing. Results: Motor coordination impairments were found in 39% of the males with XXY and 73% of the males with XXYY. Both groups showed strengths in visual perceptual skills. Males with XXYY had lower mean scores compared to males with XXY across all assessments. Fine motor dexterity and coordination deficits were common. There was a positive correlation between VMI scores and adaptive functioning. Conclusion: Occupational and physical therapists should be aware of the motor phenotype in XXY and XXYY both to aid in diagnosis of unidentified cases and to guide intervention.

Authors+Show Affiliations

a Occupational Therapy Department , Children's Hospital Colorado , Aurora , Colorado , USA. b Department of Occupational Therapy , San Jose State University , San Jose , California , USA.c Department of Pediatrics , University of Colorado School of Medicine , Aurora , Colorado , USA.b Department of Occupational Therapy , San Jose State University , San Jose , California , USA.c Department of Pediatrics , University of Colorado School of Medicine , Aurora , Colorado , USA.a Occupational Therapy Department , Children's Hospital Colorado , Aurora , Colorado , USA. c Department of Pediatrics , University of Colorado School of Medicine , Aurora , Colorado , USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30592247

Citation

Martin, Sydney, et al. "The Association of Motor Skills and Adaptive Functioning in XXY/Klinefelter and XXYY Syndromes." Physical & Occupational Therapy in Pediatrics, vol. 39, no. 4, 2019, pp. 446-459.
Martin S, Cordeiro L, Richardson P, et al. The Association of Motor Skills and Adaptive Functioning in XXY/Klinefelter and XXYY Syndromes. Phys Occup Ther Pediatr. 2019;39(4):446-459.
Martin, S., Cordeiro, L., Richardson, P., Davis, S., & Tartaglia, N. (2019). The Association of Motor Skills and Adaptive Functioning in XXY/Klinefelter and XXYY Syndromes. Physical & Occupational Therapy in Pediatrics, 39(4), 446-459. https://doi.org/10.1080/01942638.2018.1541040
Martin S, et al. The Association of Motor Skills and Adaptive Functioning in XXY/Klinefelter and XXYY Syndromes. Phys Occup Ther Pediatr. 2019;39(4):446-459. PubMed PMID: 30592247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association of Motor Skills and Adaptive Functioning in XXY/Klinefelter and XXYY Syndromes. AU - Martin,Sydney, AU - Cordeiro,Lisa, AU - Richardson,Pamela, AU - Davis,Shanlee, AU - Tartaglia,Nicole, Y1 - 2018/12/28/ PY - 2018/12/29/pubmed PY - 2020/4/18/medline PY - 2018/12/29/entrez KW - 47 KW - Klinefelter syndrome KW - activities of daily living KW - motor skills KW - occupational therapy KW - physical therapy KW - visual motor integration KW - xxy KW - xxyy SP - 446 EP - 459 JF - Physical & occupational therapy in pediatrics JO - Phys Occup Ther Pediatr VL - 39 IS - 4 N2 - Aims: Klinefelter (XXY) and XXYY syndromes are genetic disorders in males characterized by additional sex chromosomes compared to the typical male karyotype of 46, XY. Both conditions have been previously associated with motor delays and motor skills deficits. We aimed to describe and compare motor skills in males with XXY and XXYY syndromes, and to analyze associations with age, cognitive abilities, and adaptive functioning. Methods: Sixty-four males with XXY and 46 males with XXYY, ages 4-20 were evaluated using the Beery Test of Visual Motor Integration and the Bruininks-Oseretsky Test of Motor Proficiency - 2nd Edition assessments, Vineland-2 adaptive scales, and cognitive testing. Results: Motor coordination impairments were found in 39% of the males with XXY and 73% of the males with XXYY. Both groups showed strengths in visual perceptual skills. Males with XXYY had lower mean scores compared to males with XXY across all assessments. Fine motor dexterity and coordination deficits were common. There was a positive correlation between VMI scores and adaptive functioning. Conclusion: Occupational and physical therapists should be aware of the motor phenotype in XXY and XXYY both to aid in diagnosis of unidentified cases and to guide intervention. SN - 1541-3144 UR - https://www.unboundmedicine.com/medline/citation/30592247/The_Association_of_Motor_Skills_and_Adaptive_Functioning_in_XXY/Klinefelter_and_XXYY_Syndromes_ DB - PRIME DP - Unbound Medicine ER -