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Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
J Med Food 2019; 22(2):127-139JM

Abstract

Soy isoflavones may benefit some, but not all, menopausal women, and the ability of the women to produce equol may be the major determinant of effectiveness. We assessed the efficacy of soy isoflavones and equol for alleviating menopausal symptoms, especially vasomotor symptoms, in postmenopausal women who were equol producers and nonproducers by using systematic review and meta-analysis of randomized clinical trials (RCTs). We searched 12 English, Korean, and Chinese language scientific and medical databases. We selected all available RCTs that assessed the effect of equol, either equol itself or soy isoflavone in equol producers, on menopausal symptoms in peri- or postmenopausal women. The primary outcome was the effect on hot flashes. The severity of hot flashes was determined by the scores, and sensitivity and risk of bias analyses were conducted. Other outcomes of the review, but not meta-analysis, included depression and adverse events. Six studies (779 total subjects) met all criteria for the systematic review, 5 of those could be included in the meta-analysis (728 total subjects). Two studies included in the meta-analysis reported no statistically significant benefits of equol; the other three did report significant benefits of equol. Meta-analysis revealed a significant benefit of equol for lowering hot flash scores and revealed a generally low risk of bias. In conclusion, this study found that supplementing equol to equol nonproducers significantly lowered the incidence and/or severity of hot flashes in menopausal women.

Authors+Show Affiliations

1 Department of R&D, Daily Manufacturing, Inc. , Rockwell, North Carolina, USA.2 Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon, Korea.2 Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon, Korea.3 Department of Food and Nutrition, Institute of Basic Science, Obesity/Diabetes Research Center, Hoseo University , Asan, South Korea .3 Department of Food and Nutrition, Institute of Basic Science, Obesity/Diabetes Research Center, Hoseo University , Asan, South Korea .3 Department of Food and Nutrition, Institute of Basic Science, Obesity/Diabetes Research Center, Hoseo University , Asan, South Korea .

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30592686

Citation

Daily, James W., et al. "Equol Decreases Hot Flashes in Postmenopausal Women: a Systematic Review and Meta-Analysis of Randomized Clinical Trials." Journal of Medicinal Food, vol. 22, no. 2, 2019, pp. 127-139.
Daily JW, Ko BS, Ryuk J, et al. Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2019;22(2):127-139.
Daily, J. W., Ko, B. S., Ryuk, J., Liu, M., Zhang, W., & Park, S. (2019). Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food, 22(2), pp. 127-139. doi:10.1089/jmf.2018.4265.
Daily JW, et al. Equol Decreases Hot Flashes in Postmenopausal Women: a Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2019;22(2):127-139. PubMed PMID: 30592686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. AU - Daily,James W, AU - Ko,Byoung-Seob, AU - Ryuk,Jina, AU - Liu,Meiling, AU - Zhang,Weijun, AU - Park,Sunmin, Y1 - 2018/12/28/ PY - 2018/12/29/pubmed PY - 2019/5/22/medline PY - 2018/12/29/entrez KW - SP - 127 EP - 139 JF - Journal of medicinal food JO - J Med Food VL - 22 IS - 2 N2 - Soy isoflavones may benefit some, but not all, menopausal women, and the ability of the women to produce equol may be the major determinant of effectiveness. We assessed the efficacy of soy isoflavones and equol for alleviating menopausal symptoms, especially vasomotor symptoms, in postmenopausal women who were equol producers and nonproducers by using systematic review and meta-analysis of randomized clinical trials (RCTs). We searched 12 English, Korean, and Chinese language scientific and medical databases. We selected all available RCTs that assessed the effect of equol, either equol itself or soy isoflavone in equol producers, on menopausal symptoms in peri- or postmenopausal women. The primary outcome was the effect on hot flashes. The severity of hot flashes was determined by the scores, and sensitivity and risk of bias analyses were conducted. Other outcomes of the review, but not meta-analysis, included depression and adverse events. Six studies (779 total subjects) met all criteria for the systematic review, 5 of those could be included in the meta-analysis (728 total subjects). Two studies included in the meta-analysis reported no statistically significant benefits of equol; the other three did report significant benefits of equol. Meta-analysis revealed a significant benefit of equol for lowering hot flash scores and revealed a generally low risk of bias. In conclusion, this study found that supplementing equol to equol nonproducers significantly lowered the incidence and/or severity of hot flashes in menopausal women. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/30592686/Equol_Decreases_Hot_Flashes_in_Postmenopausal_Women:_A_Systematic_Review_and_Meta_Analysis_of_Randomized_Clinical_Trials_ L2 - https://www.liebertpub.com/doi/full/10.1089/jmf.2018.4265?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -