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The impact of channel fill level on internal forces during continuous twin screw wet granulation.
Int J Pharm. 2019 Mar 10; 558:91-100.IJ

Abstract

The forces experienced by the particles inside a twin screw granulator (TSG) are one of the most difficult parameters to measure quantitatively. However, it is possible to perform accurately this measurement through the use of dye containing calibrated microencapsulated sensors (CAMES) whose rupture is directly dependant on their experienced shear stress. The current study measures the extent of local stresses in the transformation from powder to granules at different channel fills during TSG processing. Channel fill has shown good potential as a design tool, however, its validity for predicting particle size distributions has yet to be demonstrated in an 11-mm TSG. The results of this study showed that the particles within the twin screw granulator experienced stresses in the range of 350-1000 kPa and this value was not linear with the specific mechanical energy applied by the granulator. It was observed that the majority of these stresses were produced by material transport processes rather than the granulation in itself. In addition it was determined that the torque required by the TSG increases exponentially after a certain channel fill a feature that requires to be considered in order to design safer, predictable and reliable granulation workspaces.

Authors+Show Affiliations

EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC), University of Strathclyde, Technology and Innovation Centre, 99 George Street, G1 1RD Glasgow, United Kingdom; Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, 161 Cathedral Street, G4 0RE Glasgow, United Kingdom. Electronic address: carlota.mendez@strath.ac.uk.R&D Platform Technology & Science GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire SG12 0DP, United Kingdom.EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC), University of Strathclyde, Technology and Innovation Centre, 99 George Street, G1 1RD Glasgow, United Kingdom; Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, 161 Cathedral Street, G4 0RE Glasgow, United Kingdom.EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC), University of Strathclyde, Technology and Innovation Centre, 99 George Street, G1 1RD Glasgow, United Kingdom; Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, 161 Cathedral Street, G4 0RE Glasgow, United Kingdom.R&D Platform Technology & Science GSK, David Jack Centre for R&D, Park Road, Ware, Hertfordshire SG12 0DP, United Kingdom.School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, BT9 7BL, United Kingdom.EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC), University of Strathclyde, Technology and Innovation Centre, 99 George Street, G1 1RD Glasgow, United Kingdom; Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, 161 Cathedral Street, G4 0RE Glasgow, United Kingdom. Electronic address: g.w.halbert@strath.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30597270

Citation

Mendez Torrecillas, Carlota, et al. "The Impact of Channel Fill Level On Internal Forces During Continuous Twin Screw Wet Granulation." International Journal of Pharmaceutics, vol. 558, 2019, pp. 91-100.
Mendez Torrecillas C, Gorringe LJ, Rajoub N, et al. The impact of channel fill level on internal forces during continuous twin screw wet granulation. Int J Pharm. 2019;558:91-100.
Mendez Torrecillas, C., Gorringe, L. J., Rajoub, N., Robertson, J., Elkes, R. G., Lamprou, D. A., & Halbert, G. W. (2019). The impact of channel fill level on internal forces during continuous twin screw wet granulation. International Journal of Pharmaceutics, 558, 91-100. https://doi.org/10.1016/j.ijpharm.2018.12.052
Mendez Torrecillas C, et al. The Impact of Channel Fill Level On Internal Forces During Continuous Twin Screw Wet Granulation. Int J Pharm. 2019 Mar 10;558:91-100. PubMed PMID: 30597270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of channel fill level on internal forces during continuous twin screw wet granulation. AU - Mendez Torrecillas,Carlota, AU - Gorringe,Lee J, AU - Rajoub,Nazer, AU - Robertson,John, AU - Elkes,Richard G, AU - Lamprou,Dimitrios A, AU - Halbert,Gavin W, Y1 - 2018/12/28/ PY - 2018/09/18/received PY - 2018/12/05/revised PY - 2018/12/15/accepted PY - 2019/1/1/pubmed PY - 2019/6/14/medline PY - 2019/1/1/entrez KW - Channel fill level KW - Continuous wet granulation KW - Design space KW - Particle size distribution KW - Stress KW - Twin screw granulation SP - 91 EP - 100 JF - International journal of pharmaceutics JO - Int J Pharm VL - 558 N2 - The forces experienced by the particles inside a twin screw granulator (TSG) are one of the most difficult parameters to measure quantitatively. However, it is possible to perform accurately this measurement through the use of dye containing calibrated microencapsulated sensors (CAMES) whose rupture is directly dependant on their experienced shear stress. The current study measures the extent of local stresses in the transformation from powder to granules at different channel fills during TSG processing. Channel fill has shown good potential as a design tool, however, its validity for predicting particle size distributions has yet to be demonstrated in an 11-mm TSG. The results of this study showed that the particles within the twin screw granulator experienced stresses in the range of 350-1000 kPa and this value was not linear with the specific mechanical energy applied by the granulator. It was observed that the majority of these stresses were produced by material transport processes rather than the granulation in itself. In addition it was determined that the torque required by the TSG increases exponentially after a certain channel fill a feature that requires to be considered in order to design safer, predictable and reliable granulation workspaces. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/30597270/The_impact_of_channel_fill_level_on_internal_forces_during_continuous_twin_screw_wet_granulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(18)30970-0 DB - PRIME DP - Unbound Medicine ER -