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Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology.
Mov Disord. 2019 02; 34(2):228-235.MD

Abstract

BACKGROUND

Organochlorine pesticides are associated with an increased risk of Parkinson's disease. A preliminary analysis from the Honolulu-Asia Aging Study suggested that heptachlor epoxide, a metabolite from an organochlorine pesticide extensively used in Hawaii, may be especially important. This was a cross sectional analysis to evaluate the association of heptachlor epoxide and other organochlorine compounds with Lewy pathology in an expanded survey of brain organochlorine residues from the longitudinal Honolulu-Asia Aging Study.

METHODS

Organochlorines were measured in frozen occipital or temporal lobes in 705 brains using gas chromatography with mass spectrometry. Lewy pathology was identified using hematoxylin and eosin- and α-synuclein immunochemistry-stained sections from multiple brain regions.

RESULTS

The prevalence of Lewy pathology was nearly doubled in the presence versus the absence of heptachlor epoxide (30.1% versus 16.3%, P < 0.001). Although associations with other compounds were weaker, hexachlorobenzene (P = 0.003) and α-chlordane (P = 0.007) were also related to Lewy pathology. Most of the latter associations, however, were a result of confounding from heptachlor epoxide. Neither compound was significantly related to Lewy pathology after adjustment for heptachlor epoxide. In contrast, the association of heptachlor epoxide with Lewy pathology remained significant after adjustments for hexachlorobenzene (P = 0.013) or α-chlordane (P = 0.005). Findings were unchanged after removal of cases of PD and adjustment for age and other characteristics.

CONCLUSIONS

Organochlorine pesticides are associated with the presence of Lewy pathology in the brain, even after exclusion of PD cases. Although most of the association is through heptachlor epoxide, the role of other organochlorine compounds is in need of clarification. © 2018 International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA. Pacific Health Research and Education Institute, Honolulu, Hawaii, USA. John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.Pacific Health Research and Education Institute, Honolulu, Hawaii, USA. Institute of Human Genomic Study, Korea University College of Medicine, Ansan, South Korea.Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA. Pacific Health Research and Education Institute, Honolulu, Hawaii, USA. John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA. Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. Department of Neurology, University of California-San Francisco, San Francisco, California, USA.Department of Neurology, Keck School of Medicine at the University of Southern California, California, Los Angeles, USA.John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA. Kuakini Medical Center, Honolulu, Hawaii, USA.National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.Tobacco Road Collaborative LLC, Raleigh, North Carolina, USA.Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA. Pacific Health Research and Education Institute, Honolulu, Hawaii, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

30597605

Citation

Ross, G Webster, et al. "Association of Brain Heptachlor Epoxide and Other Organochlorine Compounds With Lewy Pathology." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 34, no. 2, 2019, pp. 228-235.
Ross GW, Abbott RD, Petrovitch H, et al. Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology. Mov Disord. 2019;34(2):228-235.
Ross, G. W., Abbott, R. D., Petrovitch, H., Duda, J. E., Tanner, C. M., Zarow, C., Uyehara-Lock, J. H., Masaki, K. H., Launer, L. J., Studabaker, W. B., & White, L. R. (2019). Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology. Movement Disorders : Official Journal of the Movement Disorder Society, 34(2), 228-235. https://doi.org/10.1002/mds.27594
Ross GW, et al. Association of Brain Heptachlor Epoxide and Other Organochlorine Compounds With Lewy Pathology. Mov Disord. 2019;34(2):228-235. PubMed PMID: 30597605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology. AU - Ross,G Webster, AU - Abbott,Robert D, AU - Petrovitch,Helen, AU - Duda,John E, AU - Tanner,Caroline M, AU - Zarow,Chris, AU - Uyehara-Lock,Jane H, AU - Masaki,Kamal H, AU - Launer,Lenore J, AU - Studabaker,William B, AU - White,Lon R, Y1 - 2018/12/30/ PY - 2018/08/15/received PY - 2018/11/02/revised PY - 2018/11/26/accepted PY - 2019/1/1/pubmed PY - 2020/1/3/medline PY - 2019/1/1/entrez KW - Lewy pathology KW - Parkinson's disease KW - epidemiology KW - heptachlor epoxide KW - organochlorine pesticide SP - 228 EP - 235 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 34 IS - 2 N2 - BACKGROUND: Organochlorine pesticides are associated with an increased risk of Parkinson's disease. A preliminary analysis from the Honolulu-Asia Aging Study suggested that heptachlor epoxide, a metabolite from an organochlorine pesticide extensively used in Hawaii, may be especially important. This was a cross sectional analysis to evaluate the association of heptachlor epoxide and other organochlorine compounds with Lewy pathology in an expanded survey of brain organochlorine residues from the longitudinal Honolulu-Asia Aging Study. METHODS: Organochlorines were measured in frozen occipital or temporal lobes in 705 brains using gas chromatography with mass spectrometry. Lewy pathology was identified using hematoxylin and eosin- and α-synuclein immunochemistry-stained sections from multiple brain regions. RESULTS: The prevalence of Lewy pathology was nearly doubled in the presence versus the absence of heptachlor epoxide (30.1% versus 16.3%, P < 0.001). Although associations with other compounds were weaker, hexachlorobenzene (P = 0.003) and α-chlordane (P = 0.007) were also related to Lewy pathology. Most of the latter associations, however, were a result of confounding from heptachlor epoxide. Neither compound was significantly related to Lewy pathology after adjustment for heptachlor epoxide. In contrast, the association of heptachlor epoxide with Lewy pathology remained significant after adjustments for hexachlorobenzene (P = 0.013) or α-chlordane (P = 0.005). Findings were unchanged after removal of cases of PD and adjustment for age and other characteristics. CONCLUSIONS: Organochlorine pesticides are associated with the presence of Lewy pathology in the brain, even after exclusion of PD cases. Although most of the association is through heptachlor epoxide, the role of other organochlorine compounds is in need of clarification. © 2018 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/30597605/Association_of_brain_heptachlor_epoxide_and_other_organochlorine_compounds_with_lewy_pathology_ L2 - https://doi.org/10.1002/mds.27594 DB - PRIME DP - Unbound Medicine ER -