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A case of recurrent MOG antibody positive bilateral optic neuritis and anti-NMDAR encephalitis: Different biological evolution of the two associated antibodies.
J Neuroimmunol. 2019 03 15; 328:86-88.JN

Abstract

We report the clinical association of myelin-oligodendrocyte-glycoprotein (MOG) IgG-associated encephalomyelitis (MOG-EM) and anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. A 47-year old male presented to our hospital with right eye optic neuritis in February 2018. He had a history of recurrent bilateral optic neuritis since 2001 and in 2013 was treated of a anti-NMDAR encephalitis. He never had any CNS demyelination event besides optic neuritis. At the time of anti-NMDAR encephalitis both NMDAR and MOG antibodies were positive in serum and CSF. At the last visit, serum aquaporin-4 (AQP-4) and NMDAR antibodies were negative but MOG antibodies remained positive. MOG-EM and NMDAR encephalitis can present over an extended period of time without other signs of CNS demyelination and with a different temporal evolution of the associated antibodies.

Authors+Show Affiliations

General Hospital Izola, Izola, Slovenia. Electronic address: bojan.rojc@sb-izola.si.General Hospital Izola, Izola, Slovenia.Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30599296

Citation

Rojc, Bojan, et al. "A Case of Recurrent MOG Antibody Positive Bilateral Optic Neuritis and anti-NMDAR Encephalitis: Different Biological Evolution of the Two Associated Antibodies." Journal of Neuroimmunology, vol. 328, 2019, pp. 86-88.
Rojc B, Podnar B, Graus F. A case of recurrent MOG antibody positive bilateral optic neuritis and anti-NMDAR encephalitis: Different biological evolution of the two associated antibodies. J Neuroimmunol. 2019;328:86-88.
Rojc, B., Podnar, B., & Graus, F. (2019). A case of recurrent MOG antibody positive bilateral optic neuritis and anti-NMDAR encephalitis: Different biological evolution of the two associated antibodies. Journal of Neuroimmunology, 328, 86-88. https://doi.org/10.1016/j.jneuroim.2018.12.003
Rojc B, Podnar B, Graus F. A Case of Recurrent MOG Antibody Positive Bilateral Optic Neuritis and anti-NMDAR Encephalitis: Different Biological Evolution of the Two Associated Antibodies. J Neuroimmunol. 2019 03 15;328:86-88. PubMed PMID: 30599296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of recurrent MOG antibody positive bilateral optic neuritis and anti-NMDAR encephalitis: Different biological evolution of the two associated antibodies. AU - Rojc,Bojan, AU - Podnar,Barbara, AU - Graus,Francesc, Y1 - 2018/12/14/ PY - 2018/11/04/received PY - 2018/12/02/revised PY - 2018/12/12/accepted PY - 2019/1/2/pubmed PY - 2019/11/30/medline PY - 2019/1/2/entrez KW - Anti-N-methyl-d-aspartate receptor encephalitis KW - Myelin-oligodendrocyte-glycoprotein antibody KW - N-methyl-d-aspartate receptor antibody KW - Optic neuritis SP - 86 EP - 88 JF - Journal of neuroimmunology JO - J Neuroimmunol VL - 328 N2 - We report the clinical association of myelin-oligodendrocyte-glycoprotein (MOG) IgG-associated encephalomyelitis (MOG-EM) and anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. A 47-year old male presented to our hospital with right eye optic neuritis in February 2018. He had a history of recurrent bilateral optic neuritis since 2001 and in 2013 was treated of a anti-NMDAR encephalitis. He never had any CNS demyelination event besides optic neuritis. At the time of anti-NMDAR encephalitis both NMDAR and MOG antibodies were positive in serum and CSF. At the last visit, serum aquaporin-4 (AQP-4) and NMDAR antibodies were negative but MOG antibodies remained positive. MOG-EM and NMDAR encephalitis can present over an extended period of time without other signs of CNS demyelination and with a different temporal evolution of the associated antibodies. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/30599296/A_case_of_recurrent_MOG_antibody_positive_bilateral_optic_neuritis_and_anti_NMDAR_encephalitis:_Different_biological_evolution_of_the_two_associated_antibodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(18)30502-2 DB - PRIME DP - Unbound Medicine ER -