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Oral cryotherapy for prophylaxis of oral mucositis caused by docetaxel, cisplatin, and fluorouracil chemotherapy for esophageal cancer.
Esophagus. 2019 04; 16(2):207-213.E

Abstract

BACKGROUND

Chemotherapy, including preoperative chemotherapy, plays an important role in the treatment of esophageal cancer. However, although docetaxel, cisplatin, and fluorouracil (DCF) therapy has a powerful antitumor effect, the associated adverse events make it difficult to maintain the patient's general condition. Oral mucositis is an important adverse effect of chemotherapy, and its severity, frequency, and impact on patient quality of life should not be underestimated. This study evaluated the role of oral cryotherapy for prophylaxis of oral mucositis caused by DCF therapy.

METHODS

We retrospectively examined the incidence and severity of adverse events, including mucositis, in 72 patients with esophageal cancer treated with DCF. Fifty-eight patients received cryotherapy during docetaxel administration and 14 received no cryotherapy.

RESULTS

The incidence of mucositis of all grades and grade 3 was significantly lower in the cryotherapy group compared with the no-cryotherapy group (24.1% vs. 71.4%, P < 0.001 and 0% vs. 28.6%, P = 0.001, respectively). The incidence of anorexia of all grades and grade 3 was also significantly lower in the cryotherapy group (22.4% vs. 57.1%, P = 0.037 and 0% vs. 28.6%, P = 0.010, respectively).

CONCLUSION

Adjunctive oral cryotherapy is effective for the prophylaxis and relief of oral mucositis and anorexia caused by chemotherapy.

Authors+Show Affiliations

Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan. nino@staff.kanazawa-u.ac.jp.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

30600487

Citation

Okamoto, Koichi, et al. "Oral Cryotherapy for Prophylaxis of Oral Mucositis Caused By Docetaxel, Cisplatin, and Fluorouracil Chemotherapy for Esophageal Cancer." Esophagus : Official Journal of the Japan Esophageal Society, vol. 16, no. 2, 2019, pp. 207-213.
Okamoto K, Ninomiya I, Yamaguchi T, et al. Oral cryotherapy for prophylaxis of oral mucositis caused by docetaxel, cisplatin, and fluorouracil chemotherapy for esophageal cancer. Esophagus. 2019;16(2):207-213.
Okamoto, K., Ninomiya, I., Yamaguchi, T., Terai, S., Nakanuma, S., Kinoshita, J., Makino, I., Nakamura, K., Miyashita, T., Tajima, H., Takamura, H., Fushida, S., & Ohta, T. (2019). Oral cryotherapy for prophylaxis of oral mucositis caused by docetaxel, cisplatin, and fluorouracil chemotherapy for esophageal cancer. Esophagus : Official Journal of the Japan Esophageal Society, 16(2), 207-213. https://doi.org/10.1007/s10388-018-00655-8
Okamoto K, et al. Oral Cryotherapy for Prophylaxis of Oral Mucositis Caused By Docetaxel, Cisplatin, and Fluorouracil Chemotherapy for Esophageal Cancer. Esophagus. 2019;16(2):207-213. PubMed PMID: 30600487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral cryotherapy for prophylaxis of oral mucositis caused by docetaxel, cisplatin, and fluorouracil chemotherapy for esophageal cancer. AU - Okamoto,Koichi, AU - Ninomiya,Itasu, AU - Yamaguchi,Takahisa, AU - Terai,Shiro, AU - Nakanuma,Shinichi, AU - Kinoshita,Jun, AU - Makino,Isamu, AU - Nakamura,Keishi, AU - Miyashita,Tomoharu, AU - Tajima,Hidehiro, AU - Takamura,Hiroyuki, AU - Fushida,Sachio, AU - Ohta,Tetsuo, Y1 - 2019/01/01/ PY - 2018/06/13/received PY - 2018/12/21/accepted PY - 2019/1/3/pubmed PY - 2019/7/28/medline PY - 2019/1/3/entrez KW - Adverse event KW - Chemotherapy KW - Cryotherapy KW - Esophageal cancer KW - Oral mucositis SP - 207 EP - 213 JF - Esophagus : official journal of the Japan Esophageal Society JO - Esophagus VL - 16 IS - 2 N2 - BACKGROUND: Chemotherapy, including preoperative chemotherapy, plays an important role in the treatment of esophageal cancer. However, although docetaxel, cisplatin, and fluorouracil (DCF) therapy has a powerful antitumor effect, the associated adverse events make it difficult to maintain the patient's general condition. Oral mucositis is an important adverse effect of chemotherapy, and its severity, frequency, and impact on patient quality of life should not be underestimated. This study evaluated the role of oral cryotherapy for prophylaxis of oral mucositis caused by DCF therapy. METHODS: We retrospectively examined the incidence and severity of adverse events, including mucositis, in 72 patients with esophageal cancer treated with DCF. Fifty-eight patients received cryotherapy during docetaxel administration and 14 received no cryotherapy. RESULTS: The incidence of mucositis of all grades and grade 3 was significantly lower in the cryotherapy group compared with the no-cryotherapy group (24.1% vs. 71.4%, P < 0.001 and 0% vs. 28.6%, P = 0.001, respectively). The incidence of anorexia of all grades and grade 3 was also significantly lower in the cryotherapy group (22.4% vs. 57.1%, P = 0.037 and 0% vs. 28.6%, P = 0.010, respectively). CONCLUSION: Adjunctive oral cryotherapy is effective for the prophylaxis and relief of oral mucositis and anorexia caused by chemotherapy. SN - 1612-9067 UR - https://www.unboundmedicine.com/medline/citation/30600487/Oral_cryotherapy_for_prophylaxis_of_oral_mucositis_caused_by_docetaxel_cisplatin_and_fluorouracil_chemotherapy_for_esophageal_cancer_ L2 - http://www.diseaseinfosearch.org/result/5395 DB - PRIME DP - Unbound Medicine ER -