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Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density.
Aliment Pharmacol Ther. 2019 02; 49(4):375-388.AP

Abstract

BACKGROUND

Several studies have explored the effect of non-alcoholic fatty liver disease (NAFLD) on bone mineral density (BMD) and risk of osteoporotic fractures in adults. However, the extent to which NAFLD adversely affects bone health remains uncertain.

AIM

To provide a quantitative estimation of the magnitude of the association of NAFLD with BMD or history of osteoporotic fractures in adults.

METHODS

We searched PubMed, Web of Science, and Scopus using predefined keywords to identify all observational studies, published up to 31 August 2018, in which NAFLD was diagnosed by imaging or histology; BMD was measured by dual energy X-ray absorptiometry; and a self-reported history of osteoporotic fractures was collected with interviewer-assisted questionnaires. Data from selected studies were extracted, and meta-analysis was performed using random-effects modelling.

RESULTS

Twelve cross-sectional or case-control studies with aggregate data on 30 041 adults of predominantly Asian ethnicity (30% with NAFLD) were included in the final analysis. No significant differences in BMD at different skeletal sites (whole body, lumbar spine, or femur) were observed between individuals with and without NAFLD. Conversely, NAFLD was associated with increased odds of osteoporotic fractures, especially in older Chinese men (n = 2 studies; random-effects odds ratio 2.10, 95% CI 1.36-3.25; I2 = 0%). Sensitivity analyses did not alter these findings. The funnel plot and Egger test did not reveal significant publication bias.

CONCLUSIONS

This meta-analysis suggests that imaging-defined or biopsy-proven NAFLD is associated with a self-reported history of osteoporotic fractures (principally in Chinese men), but not with low BMD, in middle-aged and elderly individuals.

Authors+Show Affiliations

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Rheumatology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Rheumatology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Clinical Biochemistry, University and Azienda Ospedaliera, Universitaria Integrata of Verona, Verona, Italy.Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK. Southampton National Institute for Health Research Biomedical Research Centre, Southampton General Hospital, University Hospital Southampton, Southampton, UK.Department of Endocrinology, INSERM UMR 991, University Hospital of Rennes, Rennes Cedex 9, France.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

30600540

Citation

Mantovani, Alessandro, et al. "Systematic Review With Meta-analysis: Non-alcoholic Fatty Liver Disease Is Associated With a History of Osteoporotic Fractures but Not With Low Bone Mineral Density." Alimentary Pharmacology & Therapeutics, vol. 49, no. 4, 2019, pp. 375-388.
Mantovani A, Dauriz M, Gatti D, et al. Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. Aliment Pharmacol Ther. 2019;49(4):375-388.
Mantovani, A., Dauriz, M., Gatti, D., Viapiana, O., Zoppini, G., Lippi, G., Byrne, C. D., Bonnet, F., Bonora, E., & Targher, G. (2019). Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. Alimentary Pharmacology & Therapeutics, 49(4), 375-388. https://doi.org/10.1111/apt.15087
Mantovani A, et al. Systematic Review With Meta-analysis: Non-alcoholic Fatty Liver Disease Is Associated With a History of Osteoporotic Fractures but Not With Low Bone Mineral Density. Aliment Pharmacol Ther. 2019;49(4):375-388. PubMed PMID: 30600540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. AU - Mantovani,Alessandro, AU - Dauriz,Marco, AU - Gatti,Davide, AU - Viapiana,Ombretta, AU - Zoppini,Giacomo, AU - Lippi,Giuseppe, AU - Byrne,Christopher D, AU - Bonnet,Fabrice, AU - Bonora,Enzo, AU - Targher,Giovanni, Y1 - 2019/01/01/ PY - 2018/10/09/received PY - 2018/10/29/revised PY - 2018/11/16/accepted PY - 2019/1/3/pubmed PY - 2020/1/7/medline PY - 2019/1/3/entrez SP - 375 EP - 388 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 49 IS - 4 N2 - BACKGROUND: Several studies have explored the effect of non-alcoholic fatty liver disease (NAFLD) on bone mineral density (BMD) and risk of osteoporotic fractures in adults. However, the extent to which NAFLD adversely affects bone health remains uncertain. AIM: To provide a quantitative estimation of the magnitude of the association of NAFLD with BMD or history of osteoporotic fractures in adults. METHODS: We searched PubMed, Web of Science, and Scopus using predefined keywords to identify all observational studies, published up to 31 August 2018, in which NAFLD was diagnosed by imaging or histology; BMD was measured by dual energy X-ray absorptiometry; and a self-reported history of osteoporotic fractures was collected with interviewer-assisted questionnaires. Data from selected studies were extracted, and meta-analysis was performed using random-effects modelling. RESULTS: Twelve cross-sectional or case-control studies with aggregate data on 30 041 adults of predominantly Asian ethnicity (30% with NAFLD) were included in the final analysis. No significant differences in BMD at different skeletal sites (whole body, lumbar spine, or femur) were observed between individuals with and without NAFLD. Conversely, NAFLD was associated with increased odds of osteoporotic fractures, especially in older Chinese men (n = 2 studies; random-effects odds ratio 2.10, 95% CI 1.36-3.25; I2 = 0%). Sensitivity analyses did not alter these findings. The funnel plot and Egger test did not reveal significant publication bias. CONCLUSIONS: This meta-analysis suggests that imaging-defined or biopsy-proven NAFLD is associated with a self-reported history of osteoporotic fractures (principally in Chinese men), but not with low BMD, in middle-aged and elderly individuals. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/30600540/Systematic_review_with_meta_analysis:_non_alcoholic_fatty_liver_disease_is_associated_with_a_history_of_osteoporotic_fractures_but_not_with_low_bone_mineral_density_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=30600540.ui DB - PRIME DP - Unbound Medicine ER -