TY - JOUR T1 - An Enantioselective Cpx Rh(III)-Catalyzed C-H Functionalization/Ring-Opening Route to Chiral Cyclopentenylamines. AU - Wang,Shou-Guo, AU - Cramer,Nicolai, Y1 - 2019/01/25/ PY - 2018/12/07/received PY - 2019/1/3/pubmed PY - 2019/1/3/medline PY - 2019/1/3/entrez KW - C−H activation KW - asymmetric catalysis KW - chiral Cp ligands KW - rhodium KW - ring opening SP - 2514 EP - 2518 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 58 IS - 8 N2 - A chiral Cpx RhIII catalyst system in situ generated from a Cpx RhI (cod) precatalyst and bis(o-toluoyl) peroxide as activating oxidant was developed for a C-H activation/ring-opening sequence between aryl ketoxime ethers and 2,3-diazabicyclo[2.2.1]hept-5-enes. This transformation provides access to densely functionalized chiral cyclopentenylamines in excellent yields and enantioselectivities of up to 97:3 er. The reported method is also well suitable for asymmetric alkenyl C-H functionalizations of α,β-unsaturated oxime ethers, furnishing skipped dienes with high levels of enantiocontrol. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/30600903/An_Enantioselective_Cpx_Rh_III__Catalyzed_C_H_Functionalization/Ring_Opening_Route_to_Chiral_Cyclopentenylamines_ DB - PRIME DP - Unbound Medicine ER -