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Imaging Kayser-Fleischer Ring in Wilson Disease Using In Vivo Confocal Microscopy.
Cornea 2019; 38(3):332-337C

Abstract

PURPOSE

This study analyzes images of Kayser-Fleischer (K-F) rings in patients with Wilson disease (WD) using in vivo confocal microscopy (IVCM) and explores whether IVCM can be a useful clinical tool in facilitating the diagnosis and characterization of K-F rings.

METHODS

One hundred four eyes of 52 patients with WD and K-F rings (K-F group) and 52 normal eyes of 52 age- and gender-matched control subjects (control group) were enrolled in the study. Both K-F and control groups consisted of 29 male patients and 23 female patients. IVCM imaging was performed, and images of the peripheral Descemet membrane were analyzed.

RESULTS

All patients in K-F group showed abnormal patterns in the peripheral Descemet membrane from IVCM images. These abnormalities can be generally divided into 3 types: patchy, stripy, and spotty patterns. Each patient may have a combination of these patterns, with patchy pattern being most prevalent (100%), whereas stripy and spotty patterns are present in 30% to 40% of the K-F rings. Notably, these patterns are not correlated with other systematic symptoms of WD.

CONCLUSIONS

IVCM images can be used as an objective clinical diagnostic tool to facilitate the identification of K-F rings and the diagnosis of WD.

Authors+Show Affiliations

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China. Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.Department of General Surgery, Hunan Provincial People's Hospital, Changsha, China.Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China. Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China. Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China. Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China. Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China. Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30601285

Citation

Zhao, Tantai, et al. "Imaging Kayser-Fleischer Ring in Wilson Disease Using in Vivo Confocal Microscopy." Cornea, vol. 38, no. 3, 2019, pp. 332-337.
Zhao T, Fang Z, Tian J, et al. Imaging Kayser-Fleischer Ring in Wilson Disease Using In Vivo Confocal Microscopy. Cornea. 2019;38(3):332-337.
Zhao, T., Fang, Z., Tian, J., Liu, J., Xiao, Y., Li, H., & Chen, B. (2019). Imaging Kayser-Fleischer Ring in Wilson Disease Using In Vivo Confocal Microscopy. Cornea, 38(3), pp. 332-337. doi:10.1097/ICO.0000000000001844.
Zhao T, et al. Imaging Kayser-Fleischer Ring in Wilson Disease Using in Vivo Confocal Microscopy. Cornea. 2019;38(3):332-337. PubMed PMID: 30601285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imaging Kayser-Fleischer Ring in Wilson Disease Using In Vivo Confocal Microscopy. AU - Zhao,Tantai, AU - Fang,Zhixue, AU - Tian,Jiao, AU - Liu,Jia, AU - Xiao,Yangyan, AU - Li,Huiling, AU - Chen,Baihua, PY - 2019/1/3/pubmed PY - 2019/2/16/medline PY - 2019/1/3/entrez SP - 332 EP - 337 JF - Cornea JO - Cornea VL - 38 IS - 3 N2 - PURPOSE: This study analyzes images of Kayser-Fleischer (K-F) rings in patients with Wilson disease (WD) using in vivo confocal microscopy (IVCM) and explores whether IVCM can be a useful clinical tool in facilitating the diagnosis and characterization of K-F rings. METHODS: One hundred four eyes of 52 patients with WD and K-F rings (K-F group) and 52 normal eyes of 52 age- and gender-matched control subjects (control group) were enrolled in the study. Both K-F and control groups consisted of 29 male patients and 23 female patients. IVCM imaging was performed, and images of the peripheral Descemet membrane were analyzed. RESULTS: All patients in K-F group showed abnormal patterns in the peripheral Descemet membrane from IVCM images. These abnormalities can be generally divided into 3 types: patchy, stripy, and spotty patterns. Each patient may have a combination of these patterns, with patchy pattern being most prevalent (100%), whereas stripy and spotty patterns are present in 30% to 40% of the K-F rings. Notably, these patterns are not correlated with other systematic symptoms of WD. CONCLUSIONS: IVCM images can be used as an objective clinical diagnostic tool to facilitate the identification of K-F rings and the diagnosis of WD. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/30601285/Imaging_Kayser-Fleischer_Ring_in_Wilson_Disease_Using_In_Vivo_Confocal_Microscopy L2 - http://Insights.ovid.com/pubmed?pmid=30601285 DB - PRIME DP - Unbound Medicine ER -