Tags

Type your tag names separated by a space and hit enter

Evaluation of the oxidative stress in liver of crucian carp (Carassius auratus) exposed to 3,4,4'-tri-CDE, 2-MeO-3',4,4'-tri-CDE, and 2-HO-3',4,4'-tri-CDE.
Environ Sci Pollut Res Int. 2019 Feb; 26(5):5164-5175.ES

Abstract

Polychlorinated diphenyl ethers (PCDEs) are a class of potential persistent organic contaminants, which have been widely detected in aquatic environment. In the present study, the effects of 3,4,4'-tri-CDE and its two possible metabolites (2-MeO-3',4,4'-tri-CDE and 2-HO-3',4,4'-tri-CDE) on oxidative stress biomarkers in liver of Carassius auratus were evaluated. The fish were treated with these three compounds at different doses (0.1, 1, and 10 μg/L) via semi-static water exposure. The liver samples were individually taken at 3, 7, and 21 days for analysis of oxidative stress indicators, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and malondialdehyde (MDA). Compare to the control group, the hepatic antioxidant enzyme activity and GSH contents showed significant decreases (p < 0.05) at high-dose treatment (10 μg/L) and prolonged exposure time (21 days) in most of the toxicant-treated groups, indicating the occurrence of oxidative stress in fish liver. However, no consistent trend of the variations of antioxidant parameters was observed at low doses (0.1 and 1 μg/L). Meanwhile, the lipid peroxidation was significantly induced with extending exposure time and increasing dose. In addition, the toxicity order of three compounds was discussed using the integrated biomarker response (IBR) index. Notably, 2-HO-3',4,4'-tri-CDE was indicated to cause the most severe hepatic oxidative stress.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Cheng D
School of Resources and Environmental Engineering, Anhui University, Hefei, 230601, Anhui, China.
Cao K
Environmental Monitoring Department of Jiangxi Province, Nanchang, 330077, Jiangxi, China.
Wang T
School of Resources and Environmental Engineering, Anhui University, Hefei, 230601, Anhui, China.
Zhang X
School of Resources and Environmental Engineering, Anhui University, Hefei, 230601, Anhui, China. zhangqing8725@163.com.
Feng M
Department of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX, 77843, USA.
Liu H
College of Biological and Chemical Engineering, Jiaxing University, Jiaxing, 314001, Zhejiang, China.

MeSH

AnimalsAntioxidantsEnvironmental BiomarkersGoldfishHalogenated Diphenyl EthersLipid PeroxidationLiverOxidative StressWater Pollutants, Chemical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30604365

Citation

Cheng, Danru, et al. "Evaluation of the Oxidative Stress in Liver of Crucian Carp (Carassius Auratus) Exposed to 3,4,4'-tri-CDE, 2-MeO-3',4,4'-tri-CDE, and 2-HO-3',4,4'-tri-CDE." Environmental Science and Pollution Research International, vol. 26, no. 5, 2019, pp. 5164-5175.
Cheng D, Cao K, Wang T, et al. Evaluation of the oxidative stress in liver of crucian carp (Carassius auratus) exposed to 3,4,4'-tri-CDE, 2-MeO-3',4,4'-tri-CDE, and 2-HO-3',4,4'-tri-CDE. Environ Sci Pollut Res Int. 2019;26(5):5164-5175.
Cheng, D., Cao, K., Wang, T., Zhang, X., Feng, M., & Liu, H. (2019). Evaluation of the oxidative stress in liver of crucian carp (Carassius auratus) exposed to 3,4,4'-tri-CDE, 2-MeO-3',4,4'-tri-CDE, and 2-HO-3',4,4'-tri-CDE. Environmental Science and Pollution Research International, 26(5), 5164-5175. https://doi.org/10.1007/s11356-018-3938-2
Cheng D, et al. Evaluation of the Oxidative Stress in Liver of Crucian Carp (Carassius Auratus) Exposed to 3,4,4'-tri-CDE, 2-MeO-3',4,4'-tri-CDE, and 2-HO-3',4,4'-tri-CDE. Environ Sci Pollut Res Int. 2019;26(5):5164-5175. PubMed PMID: 30604365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the oxidative stress in liver of crucian carp (Carassius auratus) exposed to 3,4,4'-tri-CDE, 2-MeO-3',4,4'-tri-CDE, and 2-HO-3',4,4'-tri-CDE. AU - Cheng,Danru, AU - Cao,Kan, AU - Wang,Tantan, AU - Zhang,Xuesheng, AU - Feng,Mingbao, AU - Liu,Hui, Y1 - 2019/01/03/ PY - 2018/07/20/received PY - 2018/12/06/accepted PY - 2019/1/4/pubmed PY - 2019/3/30/medline PY - 2019/1/4/entrez KW - Antioxidant enzymes KW - Freshwater fish KW - Integrated biomarker response KW - Lipid peroxidation KW - Polychlorinated diphenyl ethers SP - 5164 EP - 5175 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 5 N2 - Polychlorinated diphenyl ethers (PCDEs) are a class of potential persistent organic contaminants, which have been widely detected in aquatic environment. In the present study, the effects of 3,4,4'-tri-CDE and its two possible metabolites (2-MeO-3',4,4'-tri-CDE and 2-HO-3',4,4'-tri-CDE) on oxidative stress biomarkers in liver of Carassius auratus were evaluated. The fish were treated with these three compounds at different doses (0.1, 1, and 10 μg/L) via semi-static water exposure. The liver samples were individually taken at 3, 7, and 21 days for analysis of oxidative stress indicators, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and malondialdehyde (MDA). Compare to the control group, the hepatic antioxidant enzyme activity and GSH contents showed significant decreases (p < 0.05) at high-dose treatment (10 μg/L) and prolonged exposure time (21 days) in most of the toxicant-treated groups, indicating the occurrence of oxidative stress in fish liver. However, no consistent trend of the variations of antioxidant parameters was observed at low doses (0.1 and 1 μg/L). Meanwhile, the lipid peroxidation was significantly induced with extending exposure time and increasing dose. In addition, the toxicity order of three compounds was discussed using the integrated biomarker response (IBR) index. Notably, 2-HO-3',4,4'-tri-CDE was indicated to cause the most severe hepatic oxidative stress. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/30604365/Evaluation_of_the_oxidative_stress_in_liver_of_crucian_carp__Carassius_auratus__exposed_to_344'_tri_CDE_2_MeO_3'44'_tri_CDE_and_2_HO_3'44'_tri_CDE_ DB - PRIME DP - Unbound Medicine ER -