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Fungal infections in AIDS. Histoplasmosis and coccidioidomycosis.
Infect Dis Clin North Am. 1988 Jun; 2(2):447-56.ID

Abstract

Histoplasma capsulatum and Coccidioides immitis are two fungi that are regional in occurrence and cause opportunistic fungal infections in patients with AIDS. Many cases of histoplasmosis have been reported in patients months or years after they have been in an endemic area. These are obviously cases of reactivation of latent infections. With coccidioidomycosis, the cases have been reported from endemic areas, but some also appear to be reactivation infections, and we should anticipate such cases in nonendemic areas just as with histoplasmosis. The clinical presentations may be atypical, even mimicking acute bacterial sepsis. The diagnosis should be sought in any HIV-infected patient with an unexplained infection and residence or travel in an endemic area even in the remote past. Studies should include bone marrow examinations for histoplasmosis as well as skin biopsies with special strains and cultures for fungi for both infections. Sputum or bronchoscopy specimens have often been the source of a diagnosis in coccidioidomycosis. Serologic tests for antibody in both diseases yield inconsistently positive results in AIDS patients. Treatment of the acute infection should be with amphotericin B followed by maintenance suppressive therapy with ketoconazole or Amphotericin B.

Authors+Show Affiliations

Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, New York.No affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

3060528

Citation

Minamoto, G, and D Armstrong. "Fungal Infections in AIDS. Histoplasmosis and Coccidioidomycosis." Infectious Disease Clinics of North America, vol. 2, no. 2, 1988, pp. 447-56.
Minamoto G, Armstrong D. Fungal infections in AIDS. Histoplasmosis and coccidioidomycosis. Infect Dis Clin North Am. 1988;2(2):447-56.
Minamoto, G., & Armstrong, D. (1988). Fungal infections in AIDS. Histoplasmosis and coccidioidomycosis. Infectious Disease Clinics of North America, 2(2), 447-56.
Minamoto G, Armstrong D. Fungal Infections in AIDS. Histoplasmosis and Coccidioidomycosis. Infect Dis Clin North Am. 1988;2(2):447-56. PubMed PMID: 3060528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fungal infections in AIDS. Histoplasmosis and coccidioidomycosis. AU - Minamoto,G, AU - Armstrong,D, PY - 1988/6/1/pubmed PY - 1988/6/1/medline PY - 1988/6/1/entrez SP - 447 EP - 56 JF - Infectious disease clinics of North America JO - Infect Dis Clin North Am VL - 2 IS - 2 N2 - Histoplasma capsulatum and Coccidioides immitis are two fungi that are regional in occurrence and cause opportunistic fungal infections in patients with AIDS. Many cases of histoplasmosis have been reported in patients months or years after they have been in an endemic area. These are obviously cases of reactivation of latent infections. With coccidioidomycosis, the cases have been reported from endemic areas, but some also appear to be reactivation infections, and we should anticipate such cases in nonendemic areas just as with histoplasmosis. The clinical presentations may be atypical, even mimicking acute bacterial sepsis. The diagnosis should be sought in any HIV-infected patient with an unexplained infection and residence or travel in an endemic area even in the remote past. Studies should include bone marrow examinations for histoplasmosis as well as skin biopsies with special strains and cultures for fungi for both infections. Sputum or bronchoscopy specimens have often been the source of a diagnosis in coccidioidomycosis. Serologic tests for antibody in both diseases yield inconsistently positive results in AIDS patients. Treatment of the acute infection should be with amphotericin B followed by maintenance suppressive therapy with ketoconazole or Amphotericin B. SN - 0891-5520 UR - https://www.unboundmedicine.com/medline/citation/3060528/Fungal_infections_in_AIDS__Histoplasmosis_and_coccidioidomycosis_ L2 - https://www.diseaseinfosearch.org/result/1698 DB - PRIME DP - Unbound Medicine ER -